5-Fluorouracil induces plasmonic coupling in gold nanospheres: New generation of chemotherapeutic agents

dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohamed M.B.
dc.contributor.authorAdbel-Ghani N.T.
dc.contributor.authorEl-Borady O.M.
dc.contributor.authorEl-Sayed M.A.
dc.contributor.otherNational Institute of Laser Enhanced Sciences (NILES)
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherEgypt; NanoTech Egypt for Photoelectronics
dc.contributor.otherDreamland
dc.contributor.otherOctober city
dc.contributor.otherEgypt; Chemistry Department
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherEgypt; Chemistry Department
dc.contributor.otherModern Science and Arts University
dc.contributor.otherOctober city
dc.contributor.otherEgypt; Laser dynamics laboratory
dc.contributor.otherGeorgia Institute of Technology
dc.contributor.otherAtlanta
dc.contributor.otherUnited States
dc.date.accessioned2020-01-25T19:58:27Z
dc.date.available2020-01-25T19:58:27Z
dc.date.issued2012
dc.descriptionScopus
dc.description.abstractLoading 5- Fluorouracil (5-FU) into gold nanoparticles (AuNPs) could enhance its activity as anticancer drug hugely by enhancing its ability for penetration through the cell membrane. Accordingly, this work is devoted to loading 5-FU into AuNPs surface and studying the binding mechanism of the drug to the surface of the gold nanoparticles. Our finding indicates that new absorption band appears at longer wavelength upon loading 5-FU into gold nanospheres capped with citrate. This near IR band is due to induced surface plasmon coupling via hydrogen bonding between 5-FU and surface capping AuNPs. This leads to great enhancement of the drug action as chemotherapeutic as well as photothermal agents. Factors which affect the binding between 5-FU and the AuNPs such as pH, time after mixing the drug with AuNPs, concentration of the 5-FU, have been studied in detail. Accordingly, the binding interaction is proven to be via hydrogen bonding. Upon the investigation of thermal and photo satiability, the formed composite 5-FU@AuNPs showed high stability towards these factors. The spectral and morphological studies were measured via UV-VIS spectroscopy and Transmission Electron Microscopy (HR-TEM). Remarkable increases in the drug anticancer activity upon loading into AuNPs were observed for the cell viability test of human colon cancer (HCT16). � 2012 Mohamed MB, et al.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100241608&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.4172/2157-7439.1000146
dc.identifier.doiPubMed ID :
dc.identifier.issn21577439
dc.identifier.otherhttps://doi.org/10.4172/2157-7439.1000146
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/kNNvJ
dc.language.isoEnglishen_US
dc.relation.ispartofseriesJournal of Nanomedicine and Nanotechnology
dc.relation.ispartofseries3
dc.subject5-Flourouracilen_US
dc.subjectColon canceren_US
dc.subjectCytotoxicityen_US
dc.subjectGold nanoparticlesen_US
dc.subjectPlasmonic couplingen_US
dc.title5-Fluorouracil induces plasmonic coupling in gold nanospheres: New generation of chemotherapeutic agentsen_US
dc.typeArticleen_US
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