Gefitinib Inhibits the Growth and Invasion of Urothelial Carcinoma Cell Lines in which Akt and MAPK Activation Is Dependent on Constitutive Epidermal Growth Factor Receptor Activation

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorNicolle, Gaëlle
dc.contributor.authorDaher, Ahmed
dc.contributor.authorMaillé, Pascale
dc.contributor.authorVermey, Marcel
dc.contributor.authorLoric, Sylvain
dc.contributor.authorBakkar, Ashraf
dc.contributor.authorWallerand, Hervé
dc.contributor.authorVordos, Dimitrios
dc.contributor.authorVacherot, Francis
dc.contributor.authorGil Diez De Medina, Sixtina
dc.contributor.authorC Abbou, Claude
dc.contributor.authorVan der Kwast, Theodore
dc.contributor.authorThiery, Jean-Paul
dc.contributor.authorRadvanyi, François
dc.contributor.authorK Chopin, Dominique
dc.date.accessioned2020-02-11T08:36:22Z
dc.date.available2020-02-11T08:36:22Z
dc.date.issued2006
dc.descriptionMSA Google Scholaren_US
dc.description.abstractAbnormally high levels of epidermal growth factor receptor (EGFR) protein are associated with advanced tumor stage/grade. The objective of this study was to evaluate the effects of the specific EGFR tyrosine kinase inhibitor gefitinib on activation of the Akt and mitogen-activated protein kinase (MAPK) pathways in human urothelial cell carcinoma (UCC) cell lines and to identify potential markers of gefitinib responsiveness in biopsy samples of UCC.en_US
dc.description.sponsorshipAmerican Association for Cancer Researchen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=29183&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1158/1078-0432.CCR-05-2148
dc.identifier.issn1078-0432
dc.identifier.otherhttps://doi.org/10.1158/1078-0432.CCR-05-2148
dc.identifier.urihttps://cutt.ly/krHztO6
dc.language.isoenen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.ispartofseriesClinical cancer research;VOL : 12 Issue : 9
dc.subjectUniversity for Gefitinib Inhibitsen_US
dc.subjectCarcinomaen_US
dc.subjectCell Linesen_US
dc.subjectMAPK Activationen_US
dc.subjectFactor Receptoren_US
dc.titleGefitinib Inhibits the Growth and Invasion of Urothelial Carcinoma Cell Lines in which Akt and MAPK Activation Is Dependent on Constitutive Epidermal Growth Factor Receptor Activationen_US
dc.typeArticleen_US

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