Lipid nanocarriers for tamoxifen citrate/coenzyme Q10 dual delivery

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Leithy E.S.
dc.contributor.authorAbdel-Rashid R.S.
dc.contributor.otherDepartment of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherAin Helwan
dc.contributor.otherCairo
dc.contributor.other11795
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:16Z
dc.date.available2020-01-09T20:41:16Z
dc.date.issued2017
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractNanotechnology based combinatorial therapy has emerged as an effective strategy for cancer treatment due to its synergistic activity, suppression of multi-drug resistance and successful delivery to target site. The objective of this work was to develop and characterize tamoxifen citrate (TC) and coenzyme Q10 (CoQ10) lipid nanocarriers for oral breast cancer chemotherapy. Stearic acid (2%w/v) and poloxamer188 (3%w/v) were selected as optimal lipid matrix and surfactant for development of solid lipid nanocarriers (SLNs). Incorporation of lecithin into lipid matrix (SLN9) significantly reduced particle size to 180 nm and increased %EE of CoQ10 (45%). Nanostructured lipid carriers containing 10% Labrafac oil showed further decrease in particle size reaching only 81 nm and increased %EE up to 94% and 56% for TC and CoQ10, respectively. Lipid nanocapsules showed more prominent effect on decreasing particle size (36 nm). Lipid nanocarriers offered controlled drug release profiles. The study showed that lipid carriers significantly improved drugs permeation through rabbit intestinal mucosa and suggested them as potential delivery systems for improving the bioavailability of TC/CoQ10 therapeutic molecules. Subsequent studies will be performed in order to elucidate the cytotoxicity and genotoxicity of selected lipid nanocarriers formulas on MCF-7 (adenocarcinoma breast cancer cells) versus normal cells (WISH cell line). � 2017 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=22204&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.jddst.2017.07.020
dc.identifier.doiPubMed ID :
dc.identifier.issn17732247
dc.identifier.otherhttps://doi.org/10.1016/j.jddst.2017.07.020
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/YZXpY
dc.language.isoEnglishen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofseriesJournal of Drug Delivery Science and Technology
dc.relation.ispartofseries41
dc.subjectCoenzyme Q10en_US
dc.subjectLipid nanocapsulesen_US
dc.subjectNanostructured lipid carriersen_US
dc.subjectSolid lipid nanoparticlesen_US
dc.subjectTamoxifen citrateen_US
dc.subjectnanocarrieren_US
dc.subjectpalmitic aciden_US
dc.subjectphosphatidylcholineen_US
dc.subjectpoloxameren_US
dc.subjectstearic aciden_US
dc.subjecttamoxifen citrateen_US
dc.subjectubidecarenoneen_US
dc.subjectanimal experimenten_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectconcentration (parameters)en_US
dc.subjectcontrolled drug releaseen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug penetrationen_US
dc.subjectdrug solubilityen_US
dc.subjectex vivo studyen_US
dc.subjectfreeze dryingen_US
dc.subjectintestine mucosaen_US
dc.subjectkineticsen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectOryctolagus cuniculusen_US
dc.subjectparticle sizeen_US
dc.subjectphysical chemistryen_US
dc.subjectthermographyen_US
dc.titleLipid nanocarriers for tamoxifen citrate/coenzyme Q10 dual deliveryen_US
dc.typeArticleen_US
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