New Bioactive Metabolites from a Crown Gall Induced on an Eucalyptus tereticornis Sm. Tree

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEzzat, Shahira M
dc.contributor.authorM. Salama, Maha
dc.contributor.authorSalah El Dine, Riham
dc.contributor.authorM. El-Sayed, Aly
dc.contributor.authorA. Sleem, Amany
dc.date.accessioned2019-10-21T07:35:31Z
dc.date.available2019-10-21T07:35:31Z
dc.date.issued2013
dc.description.abstractApplying a bioactivity-guided isolation strategy for the ethanolic extract of crown gall tumours induced on an Eucalyptus tereticornis tree, two new compounds in addition to a known one were isolated. The new compounds were identifi ed as an amino acid derivative named 1-ethyl-6-(1'-methyl-1'-phenylethyl) piperidin-2-one (1) and a lanostane tetracyclic triterpene named 3β-hydroxy-24-methyllanosta-8,17(20),24(28)-trien-22-oic acid (2), together with stigmasterol-3-O-glucoside (3). The three compounds exhibited signifi cant cytotoxic activity against two human cell lines, breast (MCF7) and colon (HCT116), with IC50 values of 1.01, 1.54, and 2.15 μg/ml, respectively, against MCF7 and 3.49, 3.83, and 3.39 μg/ ml, respectively, against HCT116. Furthermore, in rats elevated levels of blood cholesterol, triglycerides, and low-density lipoprotein (LDLc) were signifi cantly reduced, while the level of high-density lipoprotein (HDLc) was signifi cantly increased by administration of the etha nolic extract as well as of 3. These results support a correlation between the reduction of blood cholesterol levels and improvement of colorectal cancer.en_US
dc.description.sponsorshipZeitschrift für Naturforschungen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=14954&tip=sid&clean=0
dc.description.versionMSA Google Scholar
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dc.identifier.doihttps://doi.org/
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://cutt.ly/WteapuG
dc.language.isoenen_US
dc.publisherZeitschrift für Naturforschungen_US
dc.relation.ispartofseriesZ. Naturforsch.;68
dc.subjectUniversity of New Amino Acid Derivativesen_US
dc.subjectCrown Gallen_US
dc.titleNew Bioactive Metabolites from a Crown Gall Induced on an Eucalyptus tereticornis Sm. Treeen_US
dc.typeArticleen_US

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