Synthesis and Anti-inflammatory Activity of Some Benzofuran and Benzopyran-4-one Derivatives
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | Abd El-Fattah Ragab, Fatma | |
| dc.contributor.author | Mahmoud Eid, Nahed | |
| dc.contributor.author | Sayed Hassan, Ghaneya | |
| dc.contributor.author | Mohammed Nissan, Yassin | |
| dc.date.accessioned | 2019-10-21T07:35:18Z | |
| dc.date.available | 2019-10-21T07:35:18Z | |
| dc.date.issued | 2011 | |
| dc.description | MSA Google Scholar | |
| dc.description.abstract | New series of furosalicylic acids 3a—c, furosalicylanilides 6a—n, furobenzoxazines 8a—f, 1-benzofuran- 3-arylprop-2-en-1-ones 12a,b, 6-(aryl-3-oxoprop-1-enyl)-4H-chromen-4-ones 16a—c and 6-[6-aryl-2-thioxo- 2,5-dihydropyrimidin-4-yl]-4H-chromen-4-ones 17a—c were synthesized. Anti-inflammatory activity evaluation was performed using carrageenan-induced paw edema model in rats and prostaglandin E2 (PGE2) synthesis inhibition activity. Some of the tested compounds revealed comparable activity with less ulcerogenic effect than Diclofenac at a dose 100 mg/kg. All the synthesized compounds were docked on the active site of cyclooxygenase-2 (COX-2) enzyme and most of them showed good interactions with the amino acids of the active site comparable to the interactions exhibited by Diclofenac. | en_US |
| dc.description.sponsorship | Chemical and Pharmaceutical Bulletin | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=22769&tip=sid&clean=0 | |
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| dc.identifier.doi | https://doi.org/ | |
| dc.identifier.other | https://doi.org/ | |
| dc.identifier.uri | https://cutt.ly/prX7krr | |
| dc.language.iso | en | en_US |
| dc.publisher | Chemical and Pharmaceutical Bulletin | en_US |
| dc.subject | anti-inflammatory activity | en_US |
| dc.subject | prostaglandin E2 | en_US |
| dc.subject | benzofuran | en_US |
| dc.subject | enzopyran-4-one | en_US |
| dc.title | Synthesis and Anti-inflammatory Activity of Some Benzofuran and Benzopyran-4-one Derivatives | en_US |
| dc.type | Article | en_US |
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