Narrow band ultraviolet B therapy deactivates Th1/Th17 pathway and activates Th2 cytokines secretion in Egyptian psoriatic arthritis patients

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarid, A
dc.contributor.authorTawfik, A
dc.contributor.authorElsioufy, B
dc.contributor.authorSafwat, G
dc.date.accessioned2020-04-09T07:33:08Z
dc.date.available2020-04-09T07:33:08Z
dc.date.issued01/01/2020
dc.descriptionWOS:000522106200001en_US
dc.description.abstractPsoriasis is a chronic autoimmune disorder that affects 3-4% of the world population. Keratinocytes and immune cells in patient's skin secrets excess pro-inflammatory cytokines that in turn activates the differentiation of T helper cells (Th) into Th1 and Th17 and deactivates Th2 pathway. Several phototherapies have been used in treatment of moderate and severe psoriatic patients; among them narrowband ultraviolet B (NB-UVB, 311 nm) is the most effective. We aims to evaluate the therapeutic effect of NB-UVB exposure in 80 Egyptian plaque psoriatic patients with and without psoriasis arthritis development. This will be accomplished by measuring serum cytokines levels (IL-10, -12, -17, -23 and -34) and high sensitive C reactive protein before and after treatment. A significant elevation in Th2 pathway cytokine, IL-10, and significant decrease in Th1/Th17 pathway cytokines were observed after treatment. This indicates the success of NB-UVB therapy in down modulating IL-12 and IL-23/Th17 axis. The pathological conditions in psoriatic arthritis patients were improved by NB-UVB targeted to the skin. As serum cytokines levels in these patients indicated that the reduction in Th1/Th17 inflammatory cytokines and elevation of Th2 anti-inflammatory cytokines was not restricted to skin lesions only, but also, spread in patients' body and improve their pathologicen_US
dc.description.urihttps://www.journals.elsevier.com/journal-of-radiation-research-and-applied-sciences
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dc.identifier.doihttps://doi.org/10.1080/16878507.2020.1742443
dc.identifier.issn1687-8507
dc.identifier.otherhttps://doi.org/10.1080/16878507.2020.1742443
dc.identifier.urihttps://t.ly/pZenr
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.ispartofseriesJOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES;Volume: 13 Issue: 1 Pages: 356-361
dc.subjectuniversity of Plaque psoriasisen_US
dc.subjectNB-UVBen_US
dc.subjectIL-10en_US
dc.subjectIl-17en_US
dc.subjectIL-23en_US
dc.subjectHS-CRPen_US
dc.subjectT-CELLSen_US
dc.subjectGENE-EXPRESSIONen_US
dc.subjectSYNOVIAL-FLUIDen_US
dc.subjectINTERLEUKIN 34en_US
dc.subjectGROWTH-FACTORen_US
dc.subjectUVBen_US
dc.subjectPHOTOTHERAPYen_US
dc.subjectPUVAen_US
dc.subjectAPOPTOSISen_US
dc.subjectIL-10en_US
dc.titleNarrow band ultraviolet B therapy deactivates Th1/Th17 pathway and activates Th2 cytokines secretion in Egyptian psoriatic arthritis patientsen_US
dc.typeArticleen_US

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