Novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl)-benzenesulfonamides as cytotoxic and radiosensitizing agents

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorM Ghorab, Mostafa
dc.contributor.authorA Ragab, Fatma
dc.contributor.authorI Heiba, Helmy
dc.contributor.authorM Agha, Hebaallah
dc.contributor.authorM Nissan, Yassin
dc.date.accessioned2020-02-15T08:59:00Z
dc.date.available2020-02-15T08:59:00Z
dc.date.issued2012
dc.descriptionMSA Google Scholaren_US
dc.description.abstractA series of novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl) benzene-sulfonamides were synthesized and screened for their cytotoxic activity against human breast cancer cell line (MCF-7). Compounds 6, 7, 9, 10, 11, and 14 displayed significant activity against MCF-7 when compared to doxorubicin, which was used as a reference drug. The synergistic effect of Gamma radiation for the most active derivatives 7, 9, and 11 was also studied and their IC50 values markedly decreased to 11.9 μM, 11.7 μM, and 11.6 μM, respectivelyen_US
dc.description.sponsorshipSpringeren_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19958&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s12272-012-0106-y
dc.identifier.issn0253-6269
dc.identifier.otherhttps://doi.org/10.1007/s12272-012-0106-y
dc.identifier.urihttps://cutt.ly/prX5zY7
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofseriesArchives of pharmacal research;VOL : 35 Issue : 1
dc.subjectSulfonamidesen_US
dc.subjectThiazolesen_US
dc.subjectCytotoxicen_US
dc.subjectRadiosensetizing activitiesen_US
dc.titleNovel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl)-benzenesulfonamides as cytotoxic and radiosensitizing agentsen_US
dc.typeArticleen_US

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