Investigating the link between MCP-1 A-2518G, RANTES G-403A, CX3CR1 V249I and MTHFR C677T gene polymorphisms and the risk of acute myocardial infarction among Egyptians

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorHashad I.M.
dc.contributor.authorAbdel Rahman M.F.
dc.contributor.authorAlenina N.
dc.contributor.authorBader M.
dc.contributor.authorGad M.Z.
dc.contributor.otherClinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo (GUC)
dc.contributor.otherNew Cairo City
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.other6th of October City
dc.contributor.otherEgypt; Cardiovascular Department
dc.contributor.otherMax-Delbr�ck-Center for Molecular Medicine
dc.contributor.otherBerlin-Buch
dc.contributor.otherGermany
dc.date.accessioned2020-01-09T20:41:23Z
dc.date.available2020-01-09T20:41:23Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractBackground Acute myocardial infarction (AMI) is one of the leading causes of death among Egyptians. Monocyte chemoattractant protein-1 (MCP-1), regulation on activation normal T cell expressed and secreted (RANTES) and fractalkine (FKN) are chemokines that act as components of inflammatory response while methylenetetrahydrofolate reductase (MTHFR) is important enzyme in folate metabolism essential for homocysteine metabolism. Hyperhomocysteinemia has been linked to AMI. MCP-1 A-2518G, RANTES G-403A, CX3CR1 V249I and MTHFR C677T are important polymorphisms identified in MCP-1, RANTES, CX3CR1 and MTHFR genes respectively. There are conflicting data in the literature about their association with AMI. Therefore, the aim of the current study was to investigate the contribution of these gene variants to risk of AMI among Egyptians. Subjects and methods The study comprised 200 subjects; 100 AMI patients and 100 age-matched healthy controls. The MCP-1, RANTES, CX3CR1 and MTHFR genotypes were determined by restriction fragment length polymorphism (PCR-RFLP). Results Genotypes distributions for RANTES, fractalkine and MTHFR genes were significantly different between AMI patients and controls (p�=�0.0221, 0.0498 and 0.0083) while those results in MCP-1 were not significantly different. A significant risk for AMI with concurrent presence of RANTES (AG/AA), fractalkine (VV) and MTHFR (CT/TT) genotypes was observed. Conclusions 1 - Each of MTHFR 677T, RANTES-403A and CX3CR1 249V alleles is considered an independent risk factor for AMI. 2 - Concurrent presence of high risk genotypes of RANTES (AG/AA), fractalkine (VV) and MTHFR (CT/TT) increases risk of AMI more than their individual risks. 3 - MCP-1 polymorphism is not associated with AMI among Egyptians. � 2016 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100283722&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.mgene.2016.10.010
dc.identifier.doiPubMed ID :
dc.identifier.issn22145400
dc.identifier.otherhttps://doi.org/10.1016/j.mgene.2016.10.010
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/epW9b
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesMeta Gene
dc.relation.ispartofseries11
dc.subjectAcute myocardial infarctionen_US
dc.subjectChemokinesen_US
dc.subjectEgyptiansen_US
dc.subjectFractalkineen_US
dc.subjectMethylenetetrahydrofolate reductaseen_US
dc.subjectMonocyte chemoattractant protein-1en_US
dc.subjectRANTESen_US
dc.subjectSNPen_US
dc.subject5,10 methylenetetrahydrofolate reductase (FADH2)en_US
dc.subjectchemokine receptor CX3CR1en_US
dc.subjectgenomic DNAen_US
dc.subjectmonocyte chemotactic protein 1en_US
dc.subjectRANTESen_US
dc.subjecttriacylglycerolen_US
dc.subjectacute heart infarctionen_US
dc.subjectadulten_US
dc.subjectagar gel electrophoresisen_US
dc.subjectArticleen_US
dc.subjectblood samplingen_US
dc.subjectcholesterol blood levelen_US
dc.subjectcontrolled studyen_US
dc.subjectEgyptianen_US
dc.subjectfemaleen_US
dc.subjectgene frequencyen_US
dc.subjectgenetic risken_US
dc.subjectgenetic variabilityen_US
dc.subjectgenotypeen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectpriority journalen_US
dc.subjectrestriction fragment length polymorphismen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleInvestigating the link between MCP-1 A-2518G, RANTES G-403A, CX3CR1 V249I and MTHFR C677T gene polymorphisms and the risk of acute myocardial infarction among Egyptiansen_US
dc.typeArticleen_US
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