INTERACTIONS OF N-TERMINUS OF HUMAN RECOMBINANT FIBRILLIN-3 WITH FIBULIN-2 AND HEPARIN.

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorI. El-Hallous, Ehab
dc.contributor.authorE. Ibrahim, Nasser
dc.contributor.authorE. Ismail, Samer
dc.contributor.authorM. Montaser, Metwally
dc.date.accessioned2020-03-05T09:56:02Z
dc.date.available2020-03-05T09:56:02Z
dc.date.issued2016
dc.descriptionMSA Google Scholaren_US
dc.description.abstractFibrillins are large family of proteins that form a major constituent of microfibrils and subsequently the extracellular matrix. Fibrillin-1 is the most characterized fibrillin member and has been verified to be linked to Marfan syndrome. Fibrillin-2 was linked to congenital contractural arachnodactyly. Fibrillin-3 is expressed during tissues development and it has been linked to Weill Marchesani syndrome and polycystic ovary syndrome. Self-assembly and multiple ligand binding properties of fibrillins are crucial for the proper formation and function of microfibrils. These properties are often compromised in pathological situations. Therefore, we aimed to study the interaction epitopes of the N-terminal of fibrillin-3 with fibulin-2 and heparin in comparison to fibrillin-1, as well as the molecular shapes of the Nterminal region of fibrillin-3. In the present study we compared the binding of fibulin-2 and heparin to the N-terminal polypeptides of both fibrilin-1 and fibrillin-3. Also, we compared folding shapes of their N-termini. Our results indicated the similarity of N-termini of both fibrillin-1 and fibrillin-3 in binding to fibulin-2 and heparin as well as their structures. The N-terminal polypeptides of Fibrillin-3 can interact with Fibulin-2 and heparin in a similar fashion as compared to fibrillin-1, indicating similar functions for both isoforms.en_US
dc.description.sponsorshipINTERNATIONAL JOURNAL OF ADVANCED RESEARCHen_US
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dc.identifier.issn2320-5407
dc.identifier.urihttps://t.ly/kvPyJ
dc.language.isoenen_US
dc.publisherINTERNATIONAL JOURNAL OF ADVANCED RESEARCHen_US
dc.relation.ispartofseriesInternational Journal;Volume: 4 Issue: 2 Pages: 819-828
dc.subjectUniversity of Fibrillin, Marfan syndrome, Microfibrils, Extracellular matrix, Fibulin-2, Heparin/Heparan sulfateen_US
dc.titleINTERACTIONS OF N-TERMINUS OF HUMAN RECOMBINANT FIBRILLIN-3 WITH FIBULIN-2 AND HEPARIN.en_US
dc.typeArticleen_US

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