Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.
dc.contributor.authorMoustafa H.
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherEl Wahaat Road
dc.contributor.otherOctober City
dc.contributor.otherEgypt; Chemistry Department
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherEgypt; Applied Medical Sciences
dc.contributor.otherDepartment Community College in Quaryat
dc.contributor.otherAl Jouf University
dc.contributor.otherAl Jouf
dc.contributor.otherSaudi Arabia
dc.date.accessioned2020-01-25T19:58:31Z
dc.date.available2020-01-25T19:58:31Z
dc.date.issued2011
dc.descriptionScopus
dc.description.abstractThe aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative 2. The reactivity of the latter product towards different chemical reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly synthesized products were screened as antitumor agents on the in vitro growth of three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use in the development of oncology products.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19398&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.2478/v10007-011-0001-y
dc.identifier.doiPubMed ID 21406343
dc.identifier.issn13300075
dc.identifier.otherhttps://doi.org/10.2478/v10007-011-0001-y
dc.identifier.otherPubMed ID 21406343
dc.identifier.urihttps://t.ly/r8G1W
dc.language.isoEnglishen_US
dc.relation.ispartofseriesActa Pharmaceutica
dc.relation.ispartofseries61
dc.subjectantitumor activityen_US
dc.subjecthexahydrocinnolineen_US
dc.subjecthexahydroisoquinolineen_US
dc.subjecttetrahydronaphthaleneen_US
dc.subject2 (amino(3 oxo 2 (1,4 ditolylamino) 2,3,5,6,7,8 hexahydrocinnolin 4 yl)methylene)malononitrileen_US
dc.subject2 [amino(2,3 diamino 1 phenyl 1,2,5,6,7,8 hexahydroisoquinolin 4 yl)methylene]malononitrileen_US
dc.subject2 [amino[2,3,5,6,7,8 hexahydro 3 imino 2 (1,4 ditolylcinnoline) 4 yl]methylene]malononitrileen_US
dc.subject2 amino 3 (2 benzylidene 6 bromocyclohexylidene)prop 1 ene 1,1,3 tricarbonitrileen_US
dc.subject2 amino 3 (2 benzylidenecyclohexylidene)prop 1 ene 1,1,3 tricarbonitrileen_US
dc.subject3 amino 2 cyano 4 [2 (1,4 ditolyl hydrazono) cyclohexylidene]prop 1 ene 1,1,3 tricarbonitrileen_US
dc.subject3 amino 3 (3,5 diamino 4h pyrazol 4 ylidene) 2 cyclohexylidene propanonitrileen_US
dc.subject3 amino 3 [3 amino 5 imino 1 phenyl 1h pyrazol 4 (5h) ylidene] 2 cyclohexylidenepropanonitrileen_US
dc.subject3 amino 4 (1 amino 2,2 dicyanovinyl) 1 phenyl 5,6,7,8 tetrahydro 1 phenylnaphthalene 2 carbonitrileen_US
dc.subject4 [2 benzylidenecyclohexylidene)(cyano)methyl] 1,2,3,6 tetrahydro 6 imino 1 phenyl 2 thioxopyrimidine 5 carbonitrileen_US
dc.subjectantineoplastic agenten_US
dc.subjectcyanideen_US
dc.subjectcyclohexanoneen_US
dc.subjectethyl 3 amino 4 (1 amino 2,2 dicyanovinyl) 5,6,7,8 tetrahydro 1 phenylnaphthalene 2 carboxylateen_US
dc.subjectisoquinoline derivativeen_US
dc.subjecttetralin derivativeen_US
dc.subjectunclassified drugen_US
dc.subjectantineoplastic activityen_US
dc.subjectarticleen_US
dc.subjectbrain canceren_US
dc.subjectbreast adenocarcinomaen_US
dc.subjectcancer cell cultureen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectdrug synthesisen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectin vitro studyen_US
dc.subjectlung non small cell canceren_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectCell Line, Tumoren_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHeterocyclic Compounds, 2-Ringen_US
dc.subjectHumansen_US
dc.subjectIsoquinolinesen_US
dc.subjectNeoplasmsen_US
dc.subjectTetrahydronaphthalenesen_US
dc.titleUse of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activitiesen_US
dc.typeArticleen_US
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