Uses of cyanoacetylhydrazine in heterocyclic synthesis: Novel synthesis of pyrazole derivatives with anti-tumor activities
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | Mohareb R.M. | |
| dc.contributor.author | El-Sayed N.N.E. | |
| dc.contributor.author | Abdelaziz M.A. | |
| dc.contributor.other | Departrment of Chemistry | |
| dc.contributor.other | Faculty of Science | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Giza 12613 | |
| dc.contributor.other | Egypt; Department of Organic Chemistry | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | El-Wahaat Road | |
| dc.contributor.other | October City | |
| dc.contributor.other | Giza 12411 | |
| dc.contributor.other | Egypt; National Organization for Drug Control and Research | |
| dc.contributor.other | P.O. Box 29 | |
| dc.contributor.other | Cairo 11421 | |
| dc.contributor.other | Egypt; College of Science | |
| dc.contributor.other | Department of Chemistry | |
| dc.contributor.other | King Saud University | |
| dc.contributor.other | Riyadh 11932 | |
| dc.contributor.other | Saudi Arabia; Preparatory Year Department | |
| dc.contributor.other | AL-Ghad International Colleges for Health Sciences | |
| dc.contributor.other | Tabuk Male | |
| dc.contributor.other | Tabuk 41321 | |
| dc.contributor.other | Saudi Arabia; Basic Science Department | |
| dc.contributor.other | Modern Academy for Engineering and Technology in Maadi | |
| dc.contributor.other | Maadi 11431 | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-25T19:58:27Z | |
| dc.date.available | 2020-01-25T19:58:27Z | |
| dc.date.issued | 2012 | |
| dc.description | Scopus | |
| dc.description.abstract | The reaction of cyanoacetylhydrazine with chloroacetyl chloride gave N?-(2-chloroacetyl)-2-cyanoacetohydrazide. The latter underwent cyclization to afford 1-(5 amino-3-hydroxy-1H-pyrazol-1-yl)-2-chloroethanone, which underwent nucleophilic substitution to give 3-(5-amino-3-hydroxy-1H- pyrazol-1-yl)-3-oxopropanenitrile. The latter two compounds were used as key synthons to synthesize new thiophene, pyran, thiazole and some fused heterocyclic derivatives. The antitumor activity of the newly synthesized compounds was evaluated against three human tumor cells lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) and some of these compounds were found to exhibit much higher inhibitory effects towards the three tumor cell lines than the Gram positive control doxorubicin. � 2012 by the authors. | en_US |
| dc.identifier.doi | https://doi.org/10.3390/molecules17078449 | |
| dc.identifier.doi | PubMedID22790561 | |
| dc.identifier.issn | 14203049 | |
| dc.identifier.other | https://doi.org/10.3390/molecules17078449 | |
| dc.identifier.other | PubMedID22790561 | |
| dc.identifier.uri | https://t.ly/P5WGM | |
| dc.language.iso | English | en_US |
| dc.relation.ispartofseries | Molecules | |
| dc.relation.ispartofseries | 17 | |
| dc.subject | Antitumor | en_US |
| dc.subject | Pyrazole | en_US |
| dc.subject | Thiazole | en_US |
| dc.subject | Thiophene | en_US |
| dc.subject | antineoplastic agent | en_US |
| dc.subject | heterocyclic compound | en_US |
| dc.subject | hydrazine derivative | en_US |
| dc.subject | pyrazole | en_US |
| dc.subject | pyrazole derivative | en_US |
| dc.subject | article | en_US |
| dc.subject | chemistry | en_US |
| dc.subject | drug screening | en_US |
| dc.subject | human | en_US |
| dc.subject | structure activity relation | en_US |
| dc.subject | synthesis | en_US |
| dc.subject | tumor cell line | en_US |
| dc.subject | Antineoplastic Agents | en_US |
| dc.subject | Cell Line, Tumor | en_US |
| dc.subject | Drug Screening Assays, Antitumor | en_US |
| dc.subject | Heterocyclic Compounds | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Hydrazines | en_US |
| dc.subject | Pyrazoles | en_US |
| dc.subject | Structure-Activity Relationship | en_US |
| dc.title | Uses of cyanoacetylhydrazine in heterocyclic synthesis: Novel synthesis of pyrazole derivatives with anti-tumor activities | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus |