Online pre-column derivatization with chromatographic separation to determine folic acid

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEmara S.
dc.contributor.authorMasujima T.
dc.contributor.authorZarad W.
dc.contributor.authorKamal M.
dc.contributor.authorEi-Bagary R.
dc.contributor.otherPharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMisr International University
dc.contributor.otherKm 28 Ismailia Road
dc.contributor.otherCairo
dc.contributor.otherEgypt; Analytical Molecular Medicine and Devices Laboratory
dc.contributor.otherHiroshima University
dc.contributor.otherGraduate School of Biomedical Sciences
dc.contributor.other1-2-3
dc.contributor.otherKasumi
dc.contributor.otherMinami-ku
dc.contributor.otherHiroshima
dc.contributor.other734-8551
dc.contributor.otherJapan; Pharmaceutical Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Sciences and Arts University
dc.contributor.other26 July Mehwar Road intersection with Wahat Road
dc.contributor.other6 October City
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr El Aini St.
dc.contributor.otherCairo 11562
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:23Z
dc.date.available2020-01-09T20:42:23Z
dc.date.issued2013
dc.descriptionScopus
dc.description.abstractA simple, sensitive, and selective online pre-column derivatization high-performance liquid chromatographic method was developed and validated for the first time to determine trace levels of folic acid (FA). An oxidant cerium (IV) trihydroxyhydroperoxide packed reactor was used for pre-column oxidation and was combined by column switching with a C18 analytical column for sample enrichment and separation. The method was based on oxidative cleavage of FA into highly fluorescence products, 2-amino-4-hydroxypteridine-6-carboxaldehyde and the corresponding 2-amino-4-hydroxypteridine-6-carboxylic acid, during the flow of 0.04 M phosphate buffer (pH 3.5) containing the analyte through packed reactor at a flow rate of 0.2 mL/min and 40�C. The fluorescent products were enriched on the head of the analytical column for the final separation. The separation was performed at room temperature using a mobile phase consisting of phosphate buffer (0.04 M, pH 3.5) and acetonitrile (90:10, v/v). The eluents were monitored at emission and excitation wavelengths of 463 and 367 nm, respectively. The method showed excellent recovery, precision and accuracy with detection limits of 0.067 ng/mL from 500 L of sample FA. The developed method was successfully applied to the determination of FA in pharmaceutical formulations and showed a recovery of 99.31% and a relative standard deviation of 1.72%. 2012 � The Author [2012].en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24023&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1093/chromsci/bms170
dc.identifier.doiPubMed ID 23097580
dc.identifier.issn219665
dc.identifier.otherhttps://doi.org/10.1093/chromsci/bms170
dc.identifier.otherPubMed ID 23097580
dc.identifier.urihttps://t.ly/1VMzL
dc.language.isoEnglishen_US
dc.relation.ispartofseriesJournal of Chromatographic Science
dc.relation.ispartofseries51
dc.subjectceriumen_US
dc.subjectfolic aciden_US
dc.subjectperoxideen_US
dc.subjectarticleen_US
dc.subjectchemistryen_US
dc.subjectequipmenten_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjectisolation and purificationen_US
dc.subjectlimit of detectionen_US
dc.subjectmethodologyen_US
dc.subjectpHen_US
dc.subjectreproducibilityen_US
dc.subjectstatistical modelen_US
dc.subjecttemperatureen_US
dc.subjectCeriumen_US
dc.subjectChromatography, High Pressure Liquiden_US
dc.subjectFolic Aciden_US
dc.subjectHydrogen-Ion Concentrationen_US
dc.subjectLimit of Detectionen_US
dc.subjectLinear Modelsen_US
dc.subjectPeroxidesen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectTemperatureen_US
dc.titleOnline pre-column derivatization with chromatographic separation to determine folic aciden_US
dc.typeArticleen_US
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