Synthesis of New Benzoxazinone, Quinazolinone, and Pyrazoloquinazolinone Derivatives and Evaluation of Their Cytotoxic Activity Against Human Breast Cancer Cells

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl‐Bordany, Eman A.
dc.contributor.authorAli, Rania S
dc.date.accessioned2019-11-23T13:57:11Z
dc.date.available2019-11-23T13:57:11Z
dc.date.issued2018-05
dc.descriptionAccession Number: WOS:000433582600018en_US
dc.description.abstractSynthesis of 2-[3-(3,4-dichlorophenyl)-3-oxoprop-1-enyl]-4H-benzo[3,1]oxazin-4-one 2 as a precursor to synthesize quinazolinones 5, 7 pyrazolylquinazolinones, 4, 12, 13, 14, 16 benzothiazine thione 10, benzene derivative 3 pyrroloquinazolinone 6, benzoimidazoquinazolinone 8, and pyrazolotriazepinoquinazolinone 15. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data. Most of the synthesized compounds exhibited high antitumor and cytotoxic activity against human breast cancer cells.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=25882&tip=sid&clean=0
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dc.identifier.doihttps://doi.org/
dc.identifier.issn0022-152X
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/jhet.3158
dc.language.isoen_USen_US
dc.publisherWILEY, 111 RIVER STen_US
dc.relation.ispartofseriesJOURNAL OF HETEROCYCLIC CHEMISTRY;Volume: 55 Issue: 5 Pages: 1223-1231
dc.relation.urihttps://cutt.ly/MeVaC2P
dc.subjectKINASEen_US
dc.subjectDOCKINGen_US
dc.subjectAGENTSen_US
dc.subjectPOTENTen_US
dc.subjectINHIBITORSen_US
dc.subjectMINERALOCORTICOID RECEPTOR ANTAGONISTSen_US
dc.titleSynthesis of New Benzoxazinone, Quinazolinone, and Pyrazoloquinazolinone Derivatives and Evaluation of Their Cytotoxic Activity Against Human Breast Cancer Cellsen_US
dc.typeArticleen_US

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