Eicosapentaenoic acid and vitamin e against doxorubicin-induced cardiac and renal damages: Role of cytochrome c and inos

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFayez A.M.
dc.contributor.authorZaafan M.A.
dc.contributor.otherPharmacology and Toxicology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences
dc.contributor.otherArts
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:50Z
dc.date.available2020-01-09T20:40:50Z
dc.date.issued2018
dc.descriptionScopus
dc.description.abstractBackground: The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E. Methods: Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid treated group and a final group pretreated with vitamin E. Lipid peroxidation, reduced glutathione (GSH) and tumor necrosis factor-alpha (TNF-?) contents as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) activities were assessed. Moreover, hearts were used for immunohistochemical detection of the pro-apoptotic protein cytochrome c expression, while the kidneys were used for detection of inducible nitric oxide synthase (iNOS) expression. Results: Eicosapentaenoic acid and vitamin E produced significant protection from doxorubicin-induced cardiac and renal toxicities. The suggested mechanisms for protection included decreased cytochrome c and iNOS expression as well as markedly decreased lipid peroxides and TNF-? contents accompanied with increased GSH content as compared to the doxorubicin control group. Moreover, there was marked increase in GPx and SOD activities accompanied by significant suppression of MPO activity. Conclusion: The present study demonstrated the potent protective effects of eicosapentaenoic acid and vitamin E from doxorubicin induced cardiac and renal toxicities through their potent anti-oxidant, anti-inflammatory and anti-apoptotic properties. Hence, eicosapentaenoic acid and vitamin E could be promising protective agents against doxorubicintoxicity. � 2019, Academy of Medical Sciences of I.R. Iran. All rights reserved.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=27539&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn10292977
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/pyGM9
dc.language.isoEnglishen_US
dc.publisherAcademy of Medical Sciences of I.R. Iranen_US
dc.relation.ispartofseriesArchives of Iranian Medicine
dc.relation.ispartofseries21
dc.subjectAnti-inflammatoryen_US
dc.subjectCytochrome cen_US
dc.subjectDoxorubicinen_US
dc.subjectEicosapentaenoic aciden_US
dc.subjectINOSen_US
dc.subjectVitamin E Cite this article as: Fayez AMen_US
dc.subjectZaafan MA. Eicosapentaenoic acid and vitamin E against doxorubicin-induced cardiac and renalen_US
dc.subjectalpha tocopherolen_US
dc.subjectcreatine kinase MBen_US
dc.subjectcytochrome cen_US
dc.subjectdoxorubicinen_US
dc.subjectglutathioneen_US
dc.subjectglutathione peroxidaseen_US
dc.subjecticosapentaenoic aciden_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectlipid peroxideen_US
dc.subjectmalonaldehydeen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttumor necrosis factoren_US
dc.subjectalpha tocopherolen_US
dc.subjectantineoplastic antibioticen_US
dc.subjectcytochrome cen_US
dc.subjectdoxorubicinen_US
dc.subjectglutathione peroxidaseen_US
dc.subjecticosapentaenoic aciden_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectNos2 protein, raten_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantiapoptotic activityen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbleedingen_US
dc.subjectcell infiltrationen_US
dc.subjectcontrolled studyen_US
dc.subjectenzyme activityen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectheart injuryen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinflammationen_US
dc.subjectkidney injuryen_US
dc.subjectlipid peroxidationen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectswellingen_US
dc.subjecttissue degenerationen_US
dc.subjectanimalen_US
dc.subjectcardiac muscleen_US
dc.subjectdrug effecten_US
dc.subjecthearten_US
dc.subjectkidneyen_US
dc.subjectmetabolismen_US
dc.subjectpathologyen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectAntibiotics, Antineoplasticen_US
dc.subjectCytochromes cen_US
dc.subjectDoxorubicinen_US
dc.subjectEicosapentaenoic Aciden_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectHearten_US
dc.subjectKidneyen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMaleen_US
dc.subjectMyocardiumen_US
dc.subjectNitric Oxide Synthase Type IIen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectVitamin Een_US
dc.titleEicosapentaenoic acid and vitamin e against doxorubicin-induced cardiac and renal damages: Role of cytochrome c and inosen_US
dc.typeArticleen_US
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