An In Silico Investigation of Pharmacological Modulators and Infammasomes in Glioblastoma Multiforme

Abstract

For the past decades, infammatory signals have been considered a possible key for phar- macological interventions. There are several compounds and/or molecules that have been known as most promising medication against infammation and its mediated chronic disor- ders. Infammasomes could be recognized as a trigger by detrimental stimuli as pathogenic attack and endogenous signals mediated injury inside the cells. In addition, there has been an infammatory key mechanism involved in cancers including glioblastoma multiforme (GBM). GBM has been considered the foremost aggressive primary brain tumors in adult stage. There is a scattered beam of light on both cellular and molecular links in infamma- tion and GBM. However, the immune response of GBM has been characterized extensively by macrophages and lymphocytes related to tumors, and some recent investigations have pinpointed the focus of infammasomes on the progression of GBM. Nevertheless, risk fac- tors linked with GBM are still debatable. In our study, the most considerable compounds and their bonded and/or targeted proteins have depicted the most promising highlights under in silico condition. Our in silico investigations have revealed a powerful pharmaco- logical agents/compound against infammasome-mediated GBM.