Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSaleh D.O.
dc.contributor.authorMansour D.F.
dc.contributor.authorHashad I.M.
dc.contributor.authorBakeer R.M.
dc.contributor.otherDepartment of Pharmacology
dc.contributor.otherMedical Research Division
dc.contributor.otherThe National Research Centre
dc.contributor.other33 EL Bohouth St. (former EL Tahrir St.)
dc.contributor.otherP.O. 12622
dc.contributor.otherDokki
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Clinical Pharmacy and Pharmacy Practice
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAhram Canadian University
dc.contributor.otherEgypt; Clinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pathology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherHelwan University
dc.contributor.otherEgypt; Instructor of Pathology
dc.contributor.otherOctober University of Modern Sciences and Arts (MSA)University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:35Z
dc.date.available2020-01-09T20:40:35Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractAging; a biological phenomenon characterized by progressive decline in cellular functions, is considered as a major risk factor of various liver diseases that plays as an adverse prognostic role, thus increasing mortality rate. However, diet is the main environmental factor that has a major impact on the aging process whereas; sulforaphane (SFN), an isothiocyanate organosulfur compound in cruciferous vegetables, has been reported with myriad biological effects. In the present study, SFN antiaging properties were evaluated on D-galactose (D-Gal)-induced liver aging in rats. For this purpose, forty adult male Wistar rats were divided into five groups. All animals, except the normal control, were intraperitoneally injected with D-Gal (300 mg/kg/day for 5 days a week)for six consecutive weeks. In the hepatoprotective groups, animals received oral SFN (0.5, 1.0 and 2.0 mg/kg)for 6 weeks concurrently with D-GAL. SFN administration improved liver biomarkers through decreasing serum levels of AST, ALT, total and direct bilirubin when compared to D-Gal-aging group. SFN significantly increased hepatic GSH level as well as catalase and glutathione-S-transferase activities while counteracted the elevation in hepatic oxidative stress markers; MDA, NO and protein carbonyl in aged rats. SFN abrogated the dysregulation in hepatic Keap-1, Nrf-2 and HO-1and limited the elevation of TNF-? and TGF-? concentrations in aging liver. Histopathologically, SFN decreased the intensity of hepatic fibrous proliferation in D-Gal-induced aging. In conclusion, SFN has shown hepatic anti-aging potential through promoting the antioxidant machinery via regulating Keap-1, Nrf-2 and HO-1 and antioxidant enzyme activities as well as ameliorating oxidative stress, hampering the inflammatory cytokines; TNF-? and TGF-?, and limiting hepatic fibrosis in a dose dependent manner. � 2019 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21333&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2019.04.043
dc.identifier.doiPubMed ID 31039346
dc.identifier.issn142999
dc.identifier.otherhttps://doi.org/10.1016/j.ejphar.2019.04.043
dc.identifier.otherPubMed ID 31039346
dc.identifier.urihttps://t.ly/zN5rN
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesEuropean Journal of Pharmacology
dc.relation.ispartofseries855
dc.subjectAgingen_US
dc.subjectD-galactoseen_US
dc.subjectFibrosisen_US
dc.subjectNrf-2en_US
dc.subjectRatsen_US
dc.subjectSulforaphaneen_US
dc.subjectalanine aminotransferaseen_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectbilirubinen_US
dc.subjectcatalaseen_US
dc.subjectgalactoseen_US
dc.subjectglutathioneen_US
dc.subjectglutathione transferaseen_US
dc.subjectheme oxygenase 1en_US
dc.subjectkelch like ECH associated protein 1en_US
dc.subjectmalonaldehydeen_US
dc.subjectnitric oxideen_US
dc.subjectsulforaphaneen_US
dc.subjecttranscription factor Nrf2en_US
dc.subjecttransforming growth factor betaen_US
dc.subjecttumor necrosis factoren_US
dc.subjectantioxidanten_US
dc.subjectbiological markeren_US
dc.subjectgalactoseen_US
dc.subjectheme oxygenaseen_US
dc.subjectHmox1 protein, raten_US
dc.subjectisothiocyanic acid derivativeen_US
dc.subjectkelch like ECH associated protein 1en_US
dc.subjectNfe2l2 protein, raten_US
dc.subjectsulforafanen_US
dc.subjecttranscription factor Nrf2en_US
dc.subjecttransforming growth factor betaen_US
dc.subjecttumor necrosis factoren_US
dc.subjectadulten_US
dc.subjectagingen_US
dc.subjectalanine aminotransferase blood levelen_US
dc.subjectanimal tissueen_US
dc.subjectantiaging activityen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectaspartate aminotransferase blood levelen_US
dc.subjectbilirubin blood levelen_US
dc.subjectcell proliferationen_US
dc.subjectcontrolled studyen_US
dc.subjectdose responseen_US
dc.subjectdrug effecten_US
dc.subjectdrug efficacyen_US
dc.subjectdrug mechanismen_US
dc.subjectenzyme activityen_US
dc.subjecthistopathologyen_US
dc.subjectliveren_US
dc.subjectliver protectionen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectsignal transductionen_US
dc.subjectagingen_US
dc.subjectanimalen_US
dc.subjectblooden_US
dc.subjectcytologyen_US
dc.subjectdrug effecten_US
dc.subjectliveren_US
dc.subjectmetabolismen_US
dc.subjectWistar raten_US
dc.subjectAgingen_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectBiomarkersen_US
dc.subjectGalactoseen_US
dc.subjectHeme Oxygenase (Decyclizing)en_US
dc.subjectIsothiocyanatesen_US
dc.subjectKelch-Like ECH-Associated Protein 1en_US
dc.subjectLiveren_US
dc.subjectMaleen_US
dc.subjectNF-E2-Related Factor 2en_US
dc.subjectOxidative Stressen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectTransforming Growth Factor betaen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.titleEffects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.en_US
dc.typeArticleen_US
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