Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | El Khashab I.H. | |
| dc.contributor.author | Abdelsalam R.M. | |
| dc.contributor.author | Elbrairy A.I. | |
| dc.contributor.author | Attia A.S. | |
| dc.contributor.other | Department of Pharmacology and Toxicology | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Modern Sciences and Arts University (MSA) | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt; Department of Pharmacology and Toxicology | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:40:39Z | |
| dc.date.available | 2020-01-09T20:40:39Z | |
| dc.date.issued | 2019 | |
| dc.description | Scopus | |
| dc.description.abstract | Global cerebral ischemia is a leading cause of mortality worldwide. Several biomechanisms play a role in the pathology of cerebral ischemia reperfusion damage, such as oxidative stress, inflammation, apoptosis and excitotoxicity. Chrysin, a natural flavonoid with many important biological activities, was investigated in the present study for its possible neuroprotective properties in a rat model of global ischemia reperfusion. Male Wistar rats were allocated into three groups: sham-operated, ischemia/reperfusion, and chrysin (30 mg/kg) groups. All animals were subjected to ischemia for 15 min followed by reperfusion for 60 min, except for the sham-operated group. Rats were decapitated, then both hippocampi were rapidly excised to evaluate several biomarkers that reflect ischemic injury. The obtained results showed that pre-treatment with chrysin attenuated ischemia-induced oxidative stress by: (i) restoring the glutathione level; and (ii) depressing the levels/activities of thiobarbituric acid reactive substances, the hippocampal NADPH, as well as the xanthine oxidase. Exposure to chrysin also suppressed the inflammation accompanying the ischemia/reperfusion (I/R) damage, through increasing the interleukin-10 level, while decreasing the levels of both interleukin-6 and tumour necrosis factor-alpha. Moreover, an increase in Bcl2 and a decrease in both BAX and Hsp90 levels were recorded following chrysin exposure, which was also accompanied with elevated glutamate and aspartate levels. In conclusion, chrysin has demonstrated an anti-ischemic potential, through attenuation of the mechanisms underlying I/R injury. These data add to the knowledge on the significance of natural flavonoids as neuroprotective agents. � 2019 The Authors | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=28620&tip=sid&clean=0 | |
| dc.identifier.doi | https://doi.org/10.1016/j.biopha.2019.108619 | |
| dc.identifier.doi | PubMed ID 30797156 | |
| dc.identifier.issn | 7533322 | |
| dc.identifier.other | https://doi.org/10.1016/j.biopha.2019.108619 | |
| dc.identifier.other | PubMed ID 30797156 | |
| dc.identifier.uri | https://t.ly/rx7kx | |
| dc.language.iso | English | en_US |
| dc.publisher | Elsevier Masson SAS | en_US |
| dc.relation.ispartofseries | Biomedicine and Pharmacotherapy | |
| dc.relation.ispartofseries | 112 | |
| dc.subject | Antioxidant | en_US |
| dc.subject | Apoptosis | en_US |
| dc.subject | Chrysin | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | Ischemia-reperfusion | en_US |
| dc.subject | Neuroprotection | en_US |
| dc.subject | chrysin | en_US |
| dc.subject | interleukin 10 | en_US |
| dc.subject | interleukin 6 | en_US |
| dc.subject | neurotransmitter | en_US |
| dc.subject | protein bcl 2 | en_US |
| dc.subject | tumor necrosis factor | en_US |
| dc.subject | chrysin | en_US |
| dc.subject | flavonoid | en_US |
| dc.subject | neuroprotective agent | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | animal model | en_US |
| dc.subject | apoptosis | en_US |
| dc.subject | Article | en_US |
| dc.subject | blood brain barrier | en_US |
| dc.subject | brain ischemia | en_US |
| dc.subject | common carotid artery | en_US |
| dc.subject | comparative study | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | decapitation | en_US |
| dc.subject | enzyme activation | en_US |
| dc.subject | inflammation | en_US |
| dc.subject | male | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | oxidation reduction reaction | en_US |
| dc.subject | oxidative stress | en_US |
| dc.subject | priority journal | en_US |
| dc.subject | rat | en_US |
| dc.subject | reperfusion injury | en_US |
| dc.subject | animal | en_US |
| dc.subject | apoptosis | en_US |
| dc.subject | brain ischemia | en_US |
| dc.subject | drug effect | en_US |
| dc.subject | inflammation | en_US |
| dc.subject | metabolism | en_US |
| dc.subject | oxidative stress | en_US |
| dc.subject | pathology | en_US |
| dc.subject | physiology | en_US |
| dc.subject | Wistar rat | en_US |
| dc.subject | Animals | en_US |
| dc.subject | Apoptosis | en_US |
| dc.subject | Brain Ischemia | en_US |
| dc.subject | Flavonoids | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | Male | en_US |
| dc.subject | Neuroprotective Agents | en_US |
| dc.subject | Oxidative Stress | en_US |
| dc.subject | Rats | en_US |
| dc.subject | Rats, Wistar | en_US |
| dc.title | Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus |