Synthesis of novel tryptophan derivatives of potential biological activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.M.
dc.contributor.authorLouca N.A.
dc.contributor.authorElmegeed G.A.
dc.contributor.authorHana H.Y.
dc.contributor.otherDepartament of Organic Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modem Sciences and Arts (MSA)
dc.contributor.otherEl-Wahaat Road
dc.contributor.otherOctober City
dc.contributor.otherEgypt; Chemistry Department
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherEgypt; Hormone Department
dc.contributor.otherNational Research Centre
dc.contributor.otherDokki
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:33Z
dc.date.available2020-01-25T19:58:33Z
dc.date.issued2009
dc.descriptionScopus
dc.description.abstractTryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetonitrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding ?-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23432&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.4067/S0717-97072009000200018
dc.identifier.doiPubMed ID :
dc.identifier.issn7179324
dc.identifier.otherhttps://doi.org/10.4067/S0717-97072009000200018
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/XAzAV
dc.language.isoEnglishen_US
dc.relation.ispartofseriesJournal of the Chilean Chemical Society
dc.relation.ispartofseries54
dc.subject1en_US
dc.subject3 - oxazineen_US
dc.subjectPyrazden_US
dc.subjectPyridineen_US
dc.subjectTeyptophaneen_US
dc.titleSynthesis of novel tryptophan derivatives of potential biological activityen_US
dc.typeArticleen_US
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