Synthesis of novel tryptophan derivatives of potential biological activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.M.
dc.contributor.authorLouca N.A.
dc.contributor.authorElmegeed G.A.
dc.contributor.authorHana H.Y.
dc.contributor.otherOctober University for Modem Sciences and Arts (MSA)
dc.date.accessioned2020-01-25T19:58:33Z
dc.date.available2020-01-25T19:58:33Z
dc.date.issued2009-06
dc.descriptionSJR 2024 0.307 Q3 H-Index 44
dc.description.abstractTryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetonitrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding ?-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23432&tip=sid&clean=0
dc.identifier.citationMOHAREB, R. M., LOUCA, N. A., ELMEGEED, G. A., & HANA, H. Y. (2009). SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY. Journal of the Chilean Chemical Society, 54(2). https://doi.org/10.4067/s0717-97072009000200018 ‌
dc.identifier.doihttps://doi.org/10.4067/S0717-97072009000200018
dc.identifier.issn7179324
dc.identifier.otherhttps://doi.org/10.4067/S0717-97072009000200018
dc.identifier.urihttps://t.ly/XAzAV
dc.language.isoEnglishen_US
dc.publisherSociedad Chilena De Quimica
dc.relation.ispartofseriesJournal of the Chilean Chemical Society;vol.54 , no.2
dc.subjectTeyptophane, pyrazd, pyridine, 1,3- oxazineen_US
dc.titleSynthesis of novel tryptophan derivatives of potential biological activityen_US
dc.typeArticleen_US
dcterms.sourceScopus

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