Editorial: Inflammatory tumor microenvironment: role of cytokines and virokines in breast cancer progression and metastasis
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Date
2024-06
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Frontiers Media SA
Series Info
Frontiers in Cell and Developmental Biology;Volume 122024 Article number 1414734
Scientific Journal Rankings
Abstract
Various factors contributing to breast cancer progression and metastasis (Feng et al.,
2018; Park et al., 2022). One of these factors is the presence of inflammatory tumor
microenvironment (TME), which composed of cellular components (e.g., cancer cells,
immune cells, endothelial cells, fibroblasts, mast cells) and non-cellular components (e.g.,
extracellular matrix proteins, cytokines, chemokines, signal molecules), and it differs
significantly from the normal tissue microenvironment in terms of low vascular density,
hypoxia, weak acidity, and reducibility (Zarrilli et al., 2020). Breast cancer cells control the
function of TME components via the expression of cytokines that can increase selfproliferation, growth, and treatment resistance in an autocrine form, and encourage
recruitment, activation, and differentiation of other cells in the TME in a paracrine
approach as IL-6, IL-8, and even VEGF (Malla and Kiran, 2022; Nengroo et al., 2022;
Habanjar et al., 2023).
Description
Keywords
bone morphogenetic proteins (BMPs); breast cancer; inflammatory cytokines; inflammatory tumor microenvironment; interleukin 17 (IL-17); macrophages; RAW:iNos-eGFP reporter cell line; virokines