Effect of Physalis peruviana L. on cadmium-induced testicular toxicity in rats

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorOthman M.S.
dc.contributor.authorNada A.
dc.contributor.authorZaki H.S.
dc.contributor.authorAbdel Moneim A.E.
dc.contributor.otherFaculty of Biotechnology
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Biochemistry and Molecular Biology
dc.contributor.otherAsturias Institute of Biotechnology
dc.contributor.otherUniversity of Oviedo
dc.contributor.otherOviedo
dc.contributor.otherSpain
dc.date.accessioned2020-01-09T20:42:15Z
dc.date.available2020-01-09T20:42:15Z
dc.date.issued2014
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractCadmium (Cd) stimulates the production of reactive oxygen species and causes tissue damage. We investigated here the protective effect of Physalis peruviana L. (family Solanaceae) against cadmium-induced testes toxicity in rats. Twenty-eight Wistar albino rats were used. They were divided into four groups (n=7). Group 1 was used as control. Group 2 was intraperitoneally injected with 6.5 mg/kg body weight (bwt) of cadmium chloride for 5 days. Group 3 was orally treated with 200 mg/kg bwt of methanolic extract of physalis (MEPh). Group 4 was pretreated with MEPh before cadmium for 5 days. Changes in body and testes weights were determined. Oxidative stress markers, antioxidant enzymes, and testosterone level were measured. Histopathological changes of testes were examined, and the immunohistochemical staining for the proapoptotic (caspase-3) protein was performed. The injection of cadmium caused a significant decrease in body weight, while a significant increase in testes weight and testes weight index was observed. Pretreatment with MEPh was associated with significant reduction in the toxic effects of Cd as shown by reduced testicular levels of malondialdehyde, nitric oxide, and caspase-3 expression and increased glutathione content, and the activities of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and testosterone were also increased. Testicular histopathology showed that Cd produced an extensive germ cell apoptosis, and the pretreatment of MEPh in Cd-treated rats significantly reduced Cd-induced testicular damage. On the basis of the above results, it can be hypothesized that P. peruviana L. has a protective effect against cadmium-induced testicular oxidative stress and apoptosis in the rat. � 2014 Springer Science+Business Media.en_US
dc.identifier.doihttps://doi.org/10.1007/s12011-014-9955-1
dc.identifier.doiPubMedID24728876
dc.identifier.issn1634984
dc.identifier.otherhttps://doi.org/10.1007/s12011-014-9955-1
dc.identifier.otherPubMedID24728876
dc.identifier.urihttps://t.ly/W55vm
dc.language.isoEnglishen_US
dc.publisherMDPI AG
dc.publisherMDPI AG
dc.publisherHumana Press Inc.en_US
dc.relation.ispartofseriesBiological Trace Element Research
dc.relation.ispartofseries159
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectApoptosisen_US
dc.subjectCadmiumen_US
dc.subjectOxidative stressen_US
dc.subjectPhysalis peruviana Len_US
dc.subjectTestesen_US
dc.subjectcadmiumen_US
dc.subjectcadmium chlorideen_US
dc.subjectcaspase 3en_US
dc.subjectcatalaseen_US
dc.subjectglutathioneen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectglutathione reductaseen_US
dc.subjectmalonaldehydeen_US
dc.subjectnitric oxideen_US
dc.subjectPhysalis peruviana extracten_US
dc.subjectplant extracten_US
dc.subjectprotective agenten_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttestosteroneen_US
dc.subjectunclassified drugen_US
dc.subjectcadmiumen_US
dc.subjectcaspase 3en_US
dc.subjectglutathioneen_US
dc.subjectmalonaldehydeen_US
dc.subjectplant extracten_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectapoptosisen_US
dc.subjectarticleen_US
dc.subjectcadmium induced testicular toxicityen_US
dc.subjectcontrolled studyen_US
dc.subjectdown regulationen_US
dc.subjectenzyme activityen_US
dc.subjectfruiten_US
dc.subjectgerm cellen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectlipid peroxidationen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectPhysalisen_US
dc.subjectphysalis peruvianaen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectspermatogenesisen_US
dc.subjectsteroidogenesisen_US
dc.subjecttestis diseaseen_US
dc.subjecttestis injuryen_US
dc.subjecttestis weighten_US
dc.subjecttestosterone blood levelen_US
dc.subjectweight changeen_US
dc.subjectanimalen_US
dc.subjectchemistryen_US
dc.subjectdrug effectsen_US
dc.subjectmetabolismen_US
dc.subjecttestisen_US
dc.subjecttoxicityen_US
dc.subjectPhysalisen_US
dc.subjectPhysalis peruvianaen_US
dc.subjectRattusen_US
dc.subjectSolanaceaeen_US
dc.subjectAnimalsen_US
dc.subjectApoptosisen_US
dc.subjectCadmiumen_US
dc.subjectCaspase 3en_US
dc.subjectGlutathioneen_US
dc.subjectMaleen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative Stressen_US
dc.subjectPhysalisen_US
dc.subjectPlant Extractsen_US
dc.subjectRatsen_US
dc.subjectTestisen_US
dc.titleEffect of Physalis peruviana L. on cadmium-induced testicular toxicity in ratsen_US
dc.typeArticleen_US
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