Honey-based hydrogel: In vitro and comparative in vivo evaluation for burn wound healing
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | El-Kased R.F. | |
| dc.contributor.author | Amer R.I. | |
| dc.contributor.author | Attia D. | |
| dc.contributor.author | Elmazar M.M. | |
| dc.contributor.other | Department of Microbiology and Immunology | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | British University in Egypt | |
| dc.contributor.other | BUE Cairo | |
| dc.contributor.other | Egypt; Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy | |
| dc.contributor.other | University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Department of Pharmaceutics | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Al-Azhar University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Department of Pharmaceutics | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | British University in Egypt | |
| dc.contributor.other | BUE Cairo | |
| dc.contributor.other | Egypt; Department of Pharmacology | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | British University in Egypt | |
| dc.contributor.other | BUE Cairo | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:11Z | |
| dc.date.available | 2020-01-09T20:41:11Z | |
| dc.date.issued | 2017 | |
| dc.description | Scopus | |
| dc.description.abstract | Honey was used to treat wounds since ancient times till nowadays. The present study aimed at preparing a honey-based hydrogel and assay its antimicrobial properties and wound healing activity; in-vitro and in-vivo. Topical honey hydrogel formulations were prepared using three honey concentrations with gelling agents; chitosan and carbopol 934. The prepared formulae were evaluated for pH, spreadability, swelling index, in-vitro release and antimicrobial activity. The pH and spreadability were in the range of 4.3-6.8 and 5.7-8.6 cm, respectively. Chitosan-based hydrogel showed higher in-vitro honey release with diffusional exponent 'n ? 0.5 indicates Fickian diffusion mechanism. Hydrogel formulae were assessed for in-vitro antimicrobial activity using Disc Diffusion antibiotic sensitivity test against common burn infections bacteria; Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumonia and Streptococcus pyogenes. The 75% honey-chitosan hydrogel showed highest antimicrobial activity. This formula was tested for in-vivo burn healing using burn-induced wounds in mice. The formula was evaluated for burn healing and antibacterial activities compared to commercial product. 75% honey-chitosan hydrogel was found to possess highest healing rate of burns. The present study concludes that 75% honey-chitosan hydrogel possesses greater wound healing activity compared to commercial preparation and could be safely used as an effective natural topical wound healing treatment. � 2017 The Author(s). | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100200805&tip=sid&clean=0 | |
| dc.identifier.doi | https://doi.org/10.1038/s41598-017-08771-8 | |
| dc.identifier.doi | PubMed ID 28851905 | |
| dc.identifier.issn | 20452322 | |
| dc.identifier.other | https://doi.org/10.1038/s41598-017-08771-8 | |
| dc.identifier.other | PubMed ID 28851905 | |
| dc.identifier.uri | https://t.ly/VZLEP | |
| dc.language.iso | English | en_US |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.ispartofseries | Scientific Reports | |
| dc.relation.ispartofseries | 7 | |
| dc.subject | antiinfective agent | en_US |
| dc.subject | animal | en_US |
| dc.subject | burn | en_US |
| dc.subject | chemical phenomena | en_US |
| dc.subject | chemistry | en_US |
| dc.subject | complication | en_US |
| dc.subject | drug effect | en_US |
| dc.subject | drug formulation | en_US |
| dc.subject | drug therapy | en_US |
| dc.subject | female | en_US |
| dc.subject | honey | en_US |
| dc.subject | hydrogel | en_US |
| dc.subject | male | en_US |
| dc.subject | microbial sensitivity test | en_US |
| dc.subject | mouse | en_US |
| dc.subject | pathology | en_US |
| dc.subject | wound healing | en_US |
| dc.subject | wound infection | en_US |
| dc.subject | Animals | en_US |
| dc.subject | Anti-Infective Agents | en_US |
| dc.subject | Burns | en_US |
| dc.subject | Chemical Phenomena | en_US |
| dc.subject | Drug Compounding | en_US |
| dc.subject | Female | en_US |
| dc.subject | Honey | en_US |
| dc.subject | Hydrogels | en_US |
| dc.subject | Male | en_US |
| dc.subject | Mice | en_US |
| dc.subject | Microbial Sensitivity Tests | en_US |
| dc.subject | Wound Healing | en_US |
| dc.subject | Wound Infection | en_US |
| dc.title | Honey-based hydrogel: In vitro and comparative in vivo evaluation for burn wound healing | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus |