Is Vitamin D a participant in narrow-band ultraviolet B-induced pigmentation in patients with vitiligo?

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarag A.G.A.
dc.contributor.authorHaggag M.M.
dc.contributor.authorMuharram N.M.
dc.contributor.authorMahfouz R.
dc.contributor.authorElnaidany N.F.
dc.contributor.authorAbd El Ghany H.M.
dc.contributor.otherDepartment of Dermatology
dc.contributor.otherAndrology and STDs
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherShebin Elkom
dc.contributor.other32511
dc.contributor.otherEgypt; Department of Medical Biochemistry
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherShebin Elkom
dc.contributor.otherEgypt; Department of Clinical Pathology
dc.contributor.otherMenoufia University
dc.contributor.otherShebin Elkom
dc.contributor.otherEgypt; Department of Clinical Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherOctober City
dc.contributor.otherEgypt; Cleveland Clinic
dc.contributor.otherLerner College of Medicine (CCLCM)
dc.contributor.otherCWR University
dc.contributor.otherCleveland
dc.contributor.otherOH
dc.contributor.otherUnited States
dc.date.accessioned2020-01-09T20:41:09Z
dc.date.available2020-01-09T20:41:09Z
dc.date.issued2018
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractBackground Because of its safety and efficacy, narrow-band ultraviolet B (NBUVB) therapy has found importance in vitiligo treatment. NBUVB may promote pigmentation in vitiligo through provoked vitamin D synthesis. However, little is known about this issue. Objective To estimate the serum levels of vitamin D in patients with vitiligo before and after NBUVB therapy and to correlate its posttreatment serum levels with repigmentation. Patients and methods Fifty patients with different degrees of vitiligo severity along with 25 age-matched, sex-matched, and skin phenotype-matched controls were enrolled in this study. Patients with vitiligo were treated with NBUVB thrice weekly for 12 weeks. Baseline serum 25-hydroxyvitamin D [25(OH)D] levels (compared with controls) by enzyme-linked immunosorbent assay and Vitiligo Area and Severity Index were estimated and then reevaluated after NBUVB sessions. Results Baseline 25(OH)D levels were significantly lower in vitiligo cases than controls. After 12 weeks of NBUVB therapy, a significant clinical improvement and increase in 25(OH)D concentrations were recorded; however, insignificant correlation between both was observed. Conclusion Low vitamin D level may play an active role in vitiligo development. Furthermore, vitamin D may participate partially in photo-induced melanogenesis. Therefore, the mechanism of NBUVB-induced pigmentation in vitiligo needs to be clarified. � 2018 Egyptian Women's Dermatologic Society.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100465128&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1097/01.EWX.0000525983.54753.6
dc.identifier.doiPubMed ID :
dc.identifier.issn16871537
dc.identifier.otherhttps://doi.org/10.1097/01.EWX.0000525983.54753.6
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/vejx7
dc.language.isoEnglishen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofseriesJournal of the Egyptian Women's Dermatologic Society
dc.relation.ispartofseries15
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subject25(OH)Den_US
dc.subjectNBUVBen_US
dc.subjectrepigmentationen_US
dc.subjectvitiligoen_US
dc.subject25 hydroxyvitamin Den_US
dc.subjectvitamin Den_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectcase control studyen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisease durationen_US
dc.subjectdisease severityen_US
dc.subjecterythemaen_US
dc.subjectfamily historyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectmachineen_US
dc.subjectmaleen_US
dc.subjectmelanogenesisen_US
dc.subjectnarrow band ultraviolet B therapyen_US
dc.subjectpruritusen_US
dc.subjectrepigmentationen_US
dc.subjectskin pigmentationen_US
dc.subjecttreatment outcomeen_US
dc.subjectultraviolet B radiationen_US
dc.subjectultraviolet phototherapyen_US
dc.subjectvitamin blood levelen_US
dc.subjectvitiligoen_US
dc.titleIs Vitamin D a participant in narrow-band ultraviolet B-induced pigmentation in patients with vitiligo?en_US
dc.typeArticleen_US
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