Antitumor potential of berberine and cinnamic acid against solid ehrlich carcinoma in mice

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAlmeer R.S.
dc.contributor.authorAref A.M.
dc.contributor.authorHussein R.A.
dc.contributor.authorOthman M.S.
dc.contributor.authorMoneim A.E.A.
dc.contributor.otherDepartment of Zoology
dc.contributor.otherCollege of Science
dc.contributor.otherKing Saud University
dc.contributor.otherRiyadh
dc.contributor.otherSaudi Arabia; Faculty of Biotechnology
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Preparatory year
dc.contributor.otherUniversity of Hail
dc.contributor.otherHail
dc.contributor.otherSaudi Arabia
dc.date.accessioned2020-01-09T20:40:45Z
dc.date.available2020-01-09T20:40:45Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractBackground: Berberine and cinnamic acid are natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. Objective: In the present study, we aimed to investigate the proapoptotic potential of cinnamic acid and berberine in cancer cells by examining their effect on the expression of proapoptotic and antiapoptotic genes. Moreover, the effects of berberine and cinnamic acid on the antitumor activity of cisplatin were investigated in Ehrlich solid tumor-bearing mice. Methods: For the study, 90 male mice were inoculated intramuscularly with Ehrlich ascites tumor cells (2.5 � 106/mouse), and then on day 4, mice were randomly divided into six experimental groups (group 1-untreated Ehrlich solid tumor (EST), group 2-EST treated CDDP, group 3-EST treated CA, group 4-EST treated BER, group 5-EST treated CA + CDDP, and group 6-EST treated BER + CDDP). Result: The results showed that berberine and cinnamic acid significantly decreased tumor growth and tumor volume (- 74.8 and -75.5%, respectively) both as single agents and in combination with cisplatin. Moreover, both berberine and cinnamic acid increased the ratio of tumor growth inhibition (-91.5 and -92.6%, respectively), mean survival time (61.5 and 26 days, respectively), and percentage increase in lifespan (559 and 263%, respectively) of the treated mice. Our results also showed that both berberine and cinnamic acid-induced apoptosis by increasing the Bax/Bcl-2 ratio (74.1 and 45.1, respectively) and caspase-3 expression (14.3- and 11.6-fold increase, respectively). Additionally, berberine and cinnamic acid decreased oxidative stress markers, as shown by the decrease in lipid peroxidation and nitric oxide levels and an increase in reduced glutathione level. Conclusion: These results suggest that berberine and cinnamic acid have potential as antitumor and antioxidant agents derived from natural sources, which could be used alone or in combination with regular chemotherapeutic agents, such as cisplatin. These effects could be attributed to the proapoptotic activity of berberine and cinnamic acid. � 2019 Bentham Science Publishers.en_US
dc.identifier.doihttps://doi.org/10.2174/1871520618666181116162441
dc.identifier.doiPubMedID30451117
dc.identifier.issn18715206
dc.identifier.otherhttps://doi.org/10.2174/1871520618666181116162441
dc.identifier.otherPubMedID30451117
dc.identifier.urihttps://t.ly/1VVY7
dc.language.isoEnglishen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofseriesAnti-Cancer Agents in Medicinal Chemistry
dc.relation.ispartofseries19
dc.subjectApoptosisen_US
dc.subjectBax/Bcl-2 ratioen_US
dc.subjectBerberineen_US
dc.subjectCinnamic aciden_US
dc.subjectEhrlich solid tumoren_US
dc.subjectantineoplastic agenten_US
dc.subjectberberineen_US
dc.subjectcinnamic aciden_US
dc.subjectcinnamic acid derivativeen_US
dc.subjectmalonaldehydeen_US
dc.subjecttumor markeren_US
dc.subjectanimalen_US
dc.subjectcell proliferationen_US
dc.subjectchemical structureen_US
dc.subjectchemistryen_US
dc.subjectdose responseen_US
dc.subjectdrug effecten_US
dc.subjectdrug screeningen_US
dc.subjectEhrlich ascites tumoren_US
dc.subjectmaleen_US
dc.subjectmouseen_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectstructure activity relationen_US
dc.subjectAnimalsen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectBerberineen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectCarcinoma, Ehrlich Tumoren_US
dc.subjectCell Proliferationen_US
dc.subjectCinnamatesen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectMaleen_US
dc.subjectMalondialdehydeen_US
dc.subjectMiceen_US
dc.subjectMolecular Structureen_US
dc.subjectOxidative Stressen_US
dc.subjectStructure-Activity Relationshipen_US
dc.titleAntitumor potential of berberine and cinnamic acid against solid ehrlich carcinoma in miceen_US
dc.typeArticleen_US
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