Synthesis, characterization, and biological and anticancer studies of mixed ligand complexes with Schiff base and 2,2 '-bipyridine

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Date

2017-10

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Journal ISSN

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Type

Article

Publisher

WILEY

Series Info

APPLIED ORGANOMETALLIC CHEMISTRY;Volume: 31 Issue: 10

Abstract

New mixed ligand complexes of transition metals were synthesized from a Schiff base (L-1) obtained by the condensation reaction of oxamide and furfural as primary ligand and 2,2 '-bipyridine (L-2) as secondary ligand. The ligands and their metal complexes were studied using various spectroscopic methods. Also thermal analyses were conducted. The mixed ligand complexes were found to have formulae [M(L-1) (L-2)] Cl-m center dot nH(2)O (M = Cr(III) and Fe(III): m = 3, n = 0; M = Cu(II) and Cd(II): m = 2, n = 1; M = Mn(II), Co(II), Ni(II) and Zn(II): m = 2, n = 0). The resultant data revealed that the metal complexes have octahedral structure. Also, the mixed ligand complexes are electrolytic. The biological and anticancer activities of the new compounds were tested against breast cancer (MCF-7) and colon cancer (HCT-116) cell lines. The results showed high activity for the synthesized compounds.

Description

Accession Number: WOS:000411764500014

Keywords

CO(II), COPPER(II), ZN(II), ANTIBACTERIAL, NI(II), CU(II), ZINC(II) COMPLEXES, COORDINATION BEHAVIOR, STRUCTURAL-CHARACTERIZATION, TRANSITION-METAL-COMPLEXES, Schiff base ligand, mixed ligand complexes, biological activity, anticancer activity, 2,2 '-bipyridine

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