The association of fractalkine receptor (T280m) polymorphism in the pathogenesis of acute coronary syndrome in the Egyptian population

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorHassan D.S.
dc.contributor.authorHashad I.M.
dc.contributor.authorRahman M.F.A.
dc.contributor.authorAbdel-Maksoud S.M.
dc.contributor.otherClinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Science and Arts
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:43Z
dc.date.available2020-01-09T20:40:43Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractFractalkine (FKN) in its free and membrane bound-forms and its receptor CX3CR1are reported to have an atherosclerotic effect. The relationship of Single Nucleotide Polymorphisms (SNPs) in FKN and CX3CR1genes with the Coronary Artery Disease (CAD) risk showed conflicting results in different populations. The aim of this study was to investigate the influence of CX3CR1 threonine 280 methionine (T280M) polymorphism in the predisposition of Acute Coronary Syndrome (ACS) in Egyptians. Methods: 200 Egyptian subjects were recruited for the study. They were divided into 100 ACS patients and 100 healthy controls. Genotyping of CX3CR1 T280M was performed using a Polymerase Chain Reaction-restriction Fragment Length Polymorphism (PCR-RFLP). Serum FKN was assayed by Enzyme - Linked - Immuno- Sorbent-Assay (ELISA). Results: T and M allele frequencies for CX3CR1gene were not significantly different between ACS and Controls (p=0.76). Moreover, none of the genotypes had an atheroprotective effect. Serum analysis showed higher levels of FKN in ACS patients (p=0.041). FKN levels were not significantly different among genotypes of control and ACS groups (p=0.34) and (p=0.38) respectively. Conclusion: This study shows that CX3CR1 T280M polymorphism does not affect the incidence of ACS the Egyptian population. Moreover, none of the genotypes were associated with higher FKN levels. � 2018 Bentham Science Publishers.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=15581&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.2174/1389201019666181031163748
dc.identifier.doiPubMed ID 30381070
dc.identifier.issn13892010
dc.identifier.otherhttps://doi.org/10.2174/1389201019666181031163748
dc.identifier.otherPubMed ID 30381070
dc.identifier.urihttps://t.ly/xRmwp
dc.language.isoEnglishen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofseriesCurrent Pharmaceutical Biotechnology
dc.relation.ispartofseries19
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectAcute coronary syndromeen_US
dc.subjectCX3CR1en_US
dc.subjectEgyptiansen_US
dc.subjectFractalkine receptoren_US
dc.subjectInflammationen_US
dc.subjectT280M polymorphismen_US
dc.subjectbiochemical markeren_US
dc.subjectchemokine receptor CX3CR1en_US
dc.subjecttriacylglycerolen_US
dc.subjectchemokine receptor CX3CR1en_US
dc.subjectCX3CL1 protein, humanen_US
dc.subjectCX3CR1 protein, humanen_US
dc.subjectfractalkineen_US
dc.subjectacute coronary syndromeen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectautosomal dominant inheritanceen_US
dc.subjectautosomal recessive inheritanceen_US
dc.subjectcholesterol blood levelen_US
dc.subjectcomparative studyen_US
dc.subjectcontrolled studyen_US
dc.subjectcoronary artery atherosclerosisen_US
dc.subjectdisease predispositionen_US
dc.subjectEgyptianen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjectgene frequencyen_US
dc.subjectgenetic associationen_US
dc.subjectgenetic polymorphismen_US
dc.subjectgenetic variabilityen_US
dc.subjectgenotypeen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectnon ST segment elevation myocardial infarctionen_US
dc.subjectpathogenesisen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectprevalenceen_US
dc.subjectrestriction fragment length polymorphismen_US
dc.subjectST segment elevation myocardial infarctionen_US
dc.subjectunstable angina pectorisen_US
dc.subjectacute coronary syndromeen_US
dc.subjectEgypten_US
dc.subjectgenetic predispositionen_US
dc.subjectgeneticsen_US
dc.subjectincidenceen_US
dc.subjectmetabolismen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectChemokine CX3CL1en_US
dc.subjectCX3C Chemokine Receptor 1en_US
dc.subjectEgypten_US
dc.subjectFemaleen_US
dc.subjectGene Frequencyen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenotypeen_US
dc.subjectHumansen_US
dc.subjectIncidenceen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.titleThe association of fractalkine receptor (T280m) polymorphism in the pathogenesis of acute coronary syndrome in the Egyptian populationen_US
dc.typeArticleen_US
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