DNA Methyltransferase-1 (DNMT1): A Flow Cytometric Pharmacodynamic Assay for Azacitidine Hypomethylating Therapy after Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT)

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorM William, Basem
dc.contributor.authorWoost, Philip
dc.contributor.authorMahfouz, Reda
dc.contributor.authorBrister, Lauren
dc.contributor.authorCaimi, Paolo
dc.contributor.authorCampagnaro, Erica
dc.contributor.authorCooper, Brenda
dc.contributor.authorM Lazarus, Hillard
dc.contributor.authorSaunthararajah, Yogen
dc.contributor.authorJG de Lima, Marcos
dc.contributor.authorV Komanduri, Krishna
dc.contributor.authorJacobberger, James
dc.date.accessioned2020-03-17T10:08:22Z
dc.date.available2020-03-17T10:08:22Z
dc.date.issued2015
dc.descriptionMSA Google Scholaren_US
dc.description.abstractDisease relapse is a major cause of treatment failure following alloSCT for acute myeloid leukemia (AML). Azacitidine has shown efficacy in treating, and preventing, post-transplant relapse in patients with AML. Post-SCT azacitidine administration is challenging due to the possibility of myelosuppression and an incomplete understanding of the optimal dose and schedule. DNMT1 is responsible for genome methylation in S phase and degraded after bonding irreversibly to substituted DNA. Hence, the DNMT1 level may be an attractive pharmacodynamic (PD) endpoint for azacitidine therapyen_US
dc.description.sponsorshipElsevieren_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=25453&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.bbmt.2014.11.507
dc.identifier.issn1083-8791
dc.identifier.otherhttps://doi.org/10.1016/j.bbmt.2014.11.507
dc.identifier.urihttps://cutt.ly/QtjV5Ys
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofseriesBiology of Blood and Marrow Transplantation;VOL : 21 Issue : 2
dc.subjectDNA Methyltransferase-1 (DNMT1)en_US
dc.subjectDNAen_US
dc.subjectCytometricen_US
dc.subjectPharmacodynamicen_US
dc.subjectAzacitidineen_US
dc.subjectHypomethylatingen_US
dc.subjectAllogeneic Hematopoietic Stem Cell Transplantation (AlloSCT)en_US
dc.titleDNA Methyltransferase-1 (DNMT1): A Flow Cytometric Pharmacodynamic Assay for Azacitidine Hypomethylating Therapy after Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT)en_US
dc.typeArticleen_US

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