Molecular insight of miRNA-217 role in the pathogenesis of myocardial infarction: Promising diagnostic biomarker and therapeutic target

dc.AffiliationOctober University for modern sciences and Arts MSA
dc.contributor.authorMai A. Zaafan
dc.contributor.authorAmr M. Abdelhamid
dc.date.accessioned2024-11-09T19:46:23Z
dc.date.available2024-11-09T19:46:23Z
dc.date.issued2025-02-01
dc.description.abstractBackground: Globally, myocardial infarction (MI) is one of the main causes of death. This study aims to investigate the role of miR-217 in the pathogenesis through targeting MAPK and PI3K/AKT signaling pathways in experimental model of myocardial infarction and studying the possible cardioprotective role of dihydromyricetin (DHM) through modulation of this pathway. Methods: Dihydromyricetin was injected (100 mg/kg; p.o.) in isoprenaline induced myocardial infarction rat model for 14 days. Rats were anaesthetized and blood samples were taken for serum separation, estimation of creatine kinase-MB (CK-MB), and troponin-I levels after 24 h had passed since the last isoprenaline injection. In addition, the hearts were also used for the other biochemical studies and the histological evaluation. Results: DHM resulted in a significant suppression of the elevated levels miR-217 and MAPK compared to the MI control group and restored the normal level of serum CK-MB. Furthermore, DHM successfully restored the oxidative balance and halted the pro-inflammatory mediators in the cardiac tissue. Conclusion: Accordingly, our experiment emphasizes the anti-ischemic property that has been demonstrated through modulation of expression level of miR-217 and consequent deactivation of MAPK and PI3K/AKT signaling pathways, and this was assured by halting downstream pro-inflammatory markers.
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100823995&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.ncrna.2024.09.007
dc.identifier.otherhttps://doi.org/10.1016/j.ncrna.2024.09.007
dc.identifier.urihttps://repository.msa.edu.eg/handle/123456789/6212
dc.language.isoen
dc.publisherKeAi Communications Co.
dc.relation.ispartofseriesNon-coding RNA Research ; Volume 10, Pages 192 - 197February 2025
dc.subjectCardioprotective
dc.subjectDihydromyricetin
dc.subjectMAPK
dc.subjectmiRNA-217
dc.subjectPI3K
dc.titleMolecular insight of miRNA-217 role in the pathogenesis of myocardial infarction: Promising diagnostic biomarker and therapeutic target
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
1-s2.0-S2468054024001409-main.pdf
Size:
4.53 MB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
51 B
Format:
Item-specific license agreed upon to submission
Description: