Molecular insight of miRNA-217 role in the pathogenesis of myocardial infarction: Promising diagnostic biomarker and therapeutic target
dc.Affiliation | October University for modern sciences and Arts MSA | |
dc.contributor.author | Mai A. Zaafan | |
dc.contributor.author | Amr M. Abdelhamid | |
dc.date.accessioned | 2024-11-09T19:46:23Z | |
dc.date.available | 2024-11-09T19:46:23Z | |
dc.date.issued | 2025-02-01 | |
dc.description.abstract | Background: Globally, myocardial infarction (MI) is one of the main causes of death. This study aims to investigate the role of miR-217 in the pathogenesis through targeting MAPK and PI3K/AKT signaling pathways in experimental model of myocardial infarction and studying the possible cardioprotective role of dihydromyricetin (DHM) through modulation of this pathway. Methods: Dihydromyricetin was injected (100 mg/kg; p.o.) in isoprenaline induced myocardial infarction rat model for 14 days. Rats were anaesthetized and blood samples were taken for serum separation, estimation of creatine kinase-MB (CK-MB), and troponin-I levels after 24 h had passed since the last isoprenaline injection. In addition, the hearts were also used for the other biochemical studies and the histological evaluation. Results: DHM resulted in a significant suppression of the elevated levels miR-217 and MAPK compared to the MI control group and restored the normal level of serum CK-MB. Furthermore, DHM successfully restored the oxidative balance and halted the pro-inflammatory mediators in the cardiac tissue. Conclusion: Accordingly, our experiment emphasizes the anti-ischemic property that has been demonstrated through modulation of expression level of miR-217 and consequent deactivation of MAPK and PI3K/AKT signaling pathways, and this was assured by halting downstream pro-inflammatory markers. | |
dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100823995&tip=sid&clean=0 | |
dc.identifier.doi | https://doi.org/10.1016/j.ncrna.2024.09.007 | |
dc.identifier.other | https://doi.org/10.1016/j.ncrna.2024.09.007 | |
dc.identifier.uri | https://repository.msa.edu.eg/handle/123456789/6212 | |
dc.language.iso | en | |
dc.publisher | KeAi Communications Co. | |
dc.relation.ispartofseries | Non-coding RNA Research ; Volume 10, Pages 192 - 197February 2025 | |
dc.subject | Cardioprotective | |
dc.subject | Dihydromyricetin | |
dc.subject | MAPK | |
dc.subject | miRNA-217 | |
dc.subject | PI3K | |
dc.title | Molecular insight of miRNA-217 role in the pathogenesis of myocardial infarction: Promising diagnostic biomarker and therapeutic target | |
dc.type | Article |