Seroprevalence of occult hepatitis B among Egyptian paediatric hepatitis C cancer patients

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorRaouf H.E.
dc.contributor.authorYassin A.S.
dc.contributor.authorMegahed S.A.
dc.contributor.authorAshour M.S.
dc.contributor.authorMansour T.M.
dc.contributor.otherDepartment of Microbiology and Immunology
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Sciences and Arts University
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Microbiology and Immunology
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr El-Aini St.
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Cancer Biology Department
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:01Z
dc.date.available2020-01-09T20:42:01Z
dc.date.issued2015
dc.descriptionScopus
dc.description.abstractOccult hepatitis B infection is characterized by the presence of hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). Prevalence of hepatitis C virus (HCV) infections in Egypt is among the highest in the world. In this study, we aim at analysing the rates of occult HBV infections among HCV paediatric cancer patients in Egypt. The prevalence of occult HBV was assessed in two groups of paediatric cancer patients (HCV positive and HCV negative), in addition to a third group of paediatric noncancer patients, which was used as a general control. All groups were negative for HBsAg and positive for HCV antibody. HBV DNA was detected by nested PCR and real-time PCR. HCV was detected by real-time PCR. Sequencing was carried out in order to determine HBV genotypes to all HBV patients as well as to detect any mutation that might be responsible for the occult phenotype. Occult hepatitis B infection was observed in neither the non-HCV paediatric cancer patients nor the paediatric noncancer patients but was found in 31% of the HCV-positive paediatric cancer patients. All the detected HBV patients belonged to HBV genotype D, and mutations were found in the surface genome of HBV leading to occult HBV. Occult HBV infection seems to be relatively frequent in HCV-positive paediatric cancer patients, indicating that HBsAg negativity is not sufficient to completely exclude HBV infection. These findings emphasize the importance of considering occult HBV infection in HCV-positive paediatric cancer patients especially in endemic areas as Egypt. � 2014 John Wiley & Sons Ltd.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=25300&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1111/jvh.12260
dc.identifier.doiPubMed ID 24754376
dc.identifier.issn13520504
dc.identifier.otherhttps://doi.org/10.1111/jvh.12260
dc.identifier.otherPubMed ID 24754376
dc.identifier.urihttps://t.ly/0Ewyl
dc.language.isoEnglishen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofseriesJournal of Viral Hepatitis
dc.relation.ispartofseries22
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectCanceren_US
dc.subjectEgypten_US
dc.subjectHBVen_US
dc.subjectHCVen_US
dc.subjectoccult HBVen_US
dc.subjectpaediatricen_US
dc.subjectalanine aminotransferaseen_US
dc.subjectalkaline phosphataseen_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectbilirubinen_US
dc.subjecthepatitis B antibodyen_US
dc.subjecthepatitis B core antigenen_US
dc.subjecthepatitis B surface antigenen_US
dc.subjecthepatitis C antibodyen_US
dc.subjectvirus DNAen_US
dc.subjectadolescenten_US
dc.subjectalanine aminotransferase blood levelen_US
dc.subjectalkaline phosphatase blood levelen_US
dc.subjectArticleen_US
dc.subjectaspartate aminotransferase blood levelen_US
dc.subjectbilirubin blood levelen_US
dc.subjectcancer patienten_US
dc.subjectchilden_US
dc.subjectchildhood diseaseen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectEgyptianen_US
dc.subjectfemaleen_US
dc.subjecthepatitis Ben_US
dc.subjectHepatitis B virusen_US
dc.subjectHepatitis B virus genotype Den_US
dc.subjecthepatitis Cen_US
dc.subjectHepatitis C virusen_US
dc.subjecthumanen_US
dc.subjectinfanten_US
dc.subjectmaleen_US
dc.subjectoccult hepatitis ben_US
dc.subjectpreschool childen_US
dc.subjectprevalenceen_US
dc.subjectpriority journalen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectschool childen_US
dc.subjectseroprevalenceen_US
dc.subjectvirus detectionen_US
dc.subjectvirus loaden_US
dc.subjectblooden_US
dc.subjectchemistryen_US
dc.subjectchronic hepatitis Cen_US
dc.subjectclassificationen_US
dc.subjectcomplicationen_US
dc.subjectDNA sequenceen_US
dc.subjectEgypten_US
dc.subjectgeneticsen_US
dc.subjectgenotypeen_US
dc.subjecthepatitis Ben_US
dc.subjectisolation and purificationen_US
dc.subjectneoplasmen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectAdolescenten_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectDNA, Viralen_US
dc.subjectEgypten_US
dc.subjectFemaleen_US
dc.subjectGenotypeen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis B Surface Antigensen_US
dc.subjectHepatitis B virusen_US
dc.subjectHepatitis C Antibodiesen_US
dc.subjectHepatitis C, Chronicen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectNeoplasmsen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectReal-Time Polymerase Chain Reactionen_US
dc.subjectSequence Analysis, DNAen_US
dc.subjectSeroepidemiologic Studiesen_US
dc.titleSeroprevalence of occult hepatitis B among Egyptian paediatric hepatitis C cancer patientsen_US
dc.typeArticleen_US
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