Contribution of cyp27b1 and cyp24a1 genetic variations to the incidence of acute coronary syndrome and to vitamin d serum level

Simple item page
dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFam M.S.
dc.contributor.authorHassanein S.I.
dc.contributor.authorRahman M.F.A.
dc.contributor.authorAssal R.A.
dc.contributor.authorHanafi R.S.
dc.contributor.authorGad M.Z.
dc.contributor.otherClinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo
dc.contributor.otherFifth Settlement
dc.contributor.otherCairo
dc.contributor.other11432
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.other6th of October
dc.contributor.otherGiza 12566
dc.contributor.otherEgypt; The Molecular Pathology Research Group
dc.contributor.otherDepartment of Pharmacology and Toxicology
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo
dc.contributor.otherFifth Settlement
dc.contributor.otherCairo
dc.contributor.other11432
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo
dc.contributor.otherFifth Settlement
dc.contributor.otherCairo
dc.contributor.other11432
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:42Z
dc.date.available2020-01-09T20:40:42Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractCardiovascular diseases remain a major public health burden worldwide. It was reported that vitamin D protects the cardiovascular system through several mechanisms mainly by hindering atherosclerosis development. Genetic variations in vitamin D metabolic pathway were found to affect vitamin D levels. This study aimed at investigating the association between single nucleotide polymorphisms in genes involved in vitamin D metabolism, CYP27B and CYP24A1; 25-hydroxyvitamin D (25(OH)D) levels; and susceptibility to acute coronary syndrome (ACS). One hundred and eighty-five patients and 138 healthy controls were recruited. CYP24A1 rs2762939 was genotyped using fast real-time PCR, while CYP24A1 rs4809960 and CYP27B1 rs703842 were genotyped using polymerase chain reaction followed by restriction fragment length polymorphism (PCR�RFLP). 25(OH)D3 and 25(OH)D2 levels were measured using ultra-performance liquid chromatography tandem mass spectrum. Vitamin D level was significantly lower in patients than controls (p < 0.05). The GG genotype of rs2762939 was significantly associated with the risk of ACS development, but not correlated to the vitamin D level. rs4809960 and rs703842 genetic variations were not associated with ACS nor with 25(OH)D level. The genetic variant rs2762939 of CYP24A1 is remarkably associated with ACS. Meanwhile, the variants rs4809960 and rs703842 are not associated with ACS incidence. � 2019, Canadian Science Publishing. All rights reserved.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23363&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1139/cjpp-2019-0258
dc.identifier.doiPubMed ID 31398293
dc.identifier.issn84212
dc.identifier.otherhttps://doi.org/10.1139/cjpp-2019-0258
dc.identifier.otherPubMed ID 31398293
dc.identifier.urihttps://t.ly/0E3Lg
dc.language.isoEnglishen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofseriesCanadian Journal of Physiology and Pharmacology
dc.relation.ispartofseries97
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subject25(OH)Den_US
dc.subjectCYP24A1en_US
dc.subjectCYP27B1en_US
dc.subjectMyocardial infarctionen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subject25 hydroxyvitamin Den_US
dc.subjectcalcidiol 1 monooxygenaseen_US
dc.subjectcolecalciferol 24 hydroxylaseen_US
dc.subjectcytochromeen_US
dc.subjectcytochrome p450 27B1en_US
dc.subjectunclassified drugen_US
dc.subjectacute coronary syndromeen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectatherosclerosisen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjectgenetic susceptibilityen_US
dc.subjectgenetic variabilityen_US
dc.subjectgenetic variationen_US
dc.subjectgenotyping techniqueen_US
dc.subjecthumanen_US
dc.subjectincidenceen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectpolymerase chain reactionen_US
dc.subjectpriority journalen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectrestriction fragment length polymorphismen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectultra performance liquid chromatographyen_US
dc.subjectvitamin blood levelen_US
dc.subjectvitamin D metabolismen_US
dc.titleContribution of cyp27b1 and cyp24a1 genetic variations to the incidence of acute coronary syndrome and to vitamin d serum levelen_US
dc.typeArticleen_US
dcterms.isReferencedByAbu El Maaty, M.A., Gad, M.Z., Vitamin D deficiency and cardiovascular disease: Potential mechanisms and novel perspectives (2013) J. Nutr. Sci. Vitaminol., 59 (6), pp. 479-488. , 24477243; Abu El Maaty, M.A., Hassanein, S.I., Sleem, H.M., Gad, M.Z., Vitamin D receptor gene polymorphisms (TaqI and ApaI) in relation to 25-hydroxyvitamin D levels and coronary artery disease incidence (2015) J. Recept. Signal Transduction, 35 (5), pp. 391-395; Abu El Maaty, M.A., Hassanein, S.I., Gad, M.Z., Genetic variation in vitamin D receptor gene (Fok1: Rs2228570) is associated with risk of coronary artery disease (2016) Biomarkers, 21 (1), pp. 68-72. , 26643870; Agnello, L., Scazzone, C., Sasso, B.L., Bellia, C., Bivona, G., Realmuto, S., VDBP, CYP27B1, and 25-hydroxyvitamin D gene polymorphism analyses in a group of Sicilian multiple sclerosis patients (2017) Biochem. Genet., 55 (2), pp. 183-192. , 27904983; Al Anouti, F., Chehadeh, S.E.H., Osman, E., Elghazali, G., Al Safar, H., Investigating the association of vitamin D metabolism genes CYP2R1, CYP24A1 and CYP27B1 with vitamin D status in young adult Emiratis (2017) J. Food Nutr. Res, 5 (1), pp. 15-21; Bikle, D.D., Vitamin D metabolism, mechanism of action, and clinical applications (2014) Chem. Biol., 21 (3), pp. 319-329. , 24529992; Deluca, H.F., History of the discovery of vitamin D and its active metabolites (2014) Bonekey Rep, 3, p. 479. , 24466410; Ellfolk, M., (2008) Regulation of Vitamin D 25-Hydroxylases: Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D, , Acta Universitatis Upsaliensis; Hibler, E.A., Klimentidis, Y.C., Jurutka, P.W., Kohler, L.N., Lance, P., Roe, D.J., CYP24A1 and CYP27B1 polymorphisms, concentrations of vitamin D metabolites, and odds of colorectal adenoma recurrence (2015) Nutr. Cancer, 67 (7), pp. 1131-1141. , 26241700; Jiang, T., Li, L., Wang, Y., Zhao, C., Yang, J., Ma, D., The association between genetic polymorphism rs703842 in CYP27B1 and multiple sclerosis: A meta-analysis (2016) Medicine, 95 (19). , 27175669; Jorde, R., Schirmer, H., Wilsgaard, T., Joakimsen, R.M., Mathiesen, E.B., Nj�lstad, I., Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Troms� Study (2012) Plos ONE, 7 (5). , 22649517; Judd, S.E., Tangpricha, V., Vitamin D deficiency and risk for cardiovascular disease (2009) Am. J. Med. Sci., 338 (1), pp. 40-44. , 19593102; Kassi, E., Adamopoulos, C., Basdra, E.K., Papavassiliou, A.G., Role of vitamin D in atherosclerosis (2013) Circulation, 128 (23), pp. 2517-2531. , 24297817; Kienreich, K., Tomaschitz, A., Verheyen, N., Pieber, T., Gaksch, M., Gr�bler, M.R., Pilz, S., Vitamin D and cardiovascular disease (2013) Nutrients, 5 (8), pp. 3005-3021. , 23912328; Lewis, C.M., Knight, J., Introduction to genetic association studies (2012) Cold Spring Harb. Protoc., (3), pp. 297-306. , 2012, 22383645; Menezes, A.R., Lamb, M.C., Lavie, C.J., Dinicolantonio, J.J., Vitamin D and atherosclerosis (2014) Curr. Opin. Cardiol., 29 (6), pp. 571-577. , 25144342; Morris, H.A., Anderson, P.H., (2010) Autocrine and Paracrine Actions of Vitamin D, , Citeseer; Morrison, M.A., Silveira, A.C., Huynh, N., Jun, G., Smith, S.E., Zacharaki, F., Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration (2011) Hum. Genomics, 5 (6), p. 538. , 22155603; Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M., Executive summary: Heart Disease and Stroke Statistics-2016 update: A report from the American Heart Association (2016) Circulation, 133 (4), p. 447; Nair, R., Maseeh, A., Vitamin D: The �sunshine� vitamin (2012) J. Pharmacol. Pharmacother, 3 (2), p. 118. , 22629085; Nissen, J., Rasmussen, L.B., Ravn-Haren, G., Andersen, E.W., Hansen, B., Andersen, R., Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults (2014) Plos ONE, 9 (2). , 24587115; Pilz, S., Gaksch, M., O�Hartaigh, B., Tomaschitz, A., M�rz, W., The role of vitamin D deficiency in cardiovascular disease: Where do we stand in 2013? (2013) Arch. Toxicol., 87 (12), pp. 2083-2103. , 24173581; Ramnath, N., Daignault-Newton, S., Dy, G., Muindi, J., Adjei, A., Elingrod, V., A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer (2013) Cancer Chemother. Pharmacol., 71 (5), pp. 1173-1182. , 23435876; Reimers, L.L., Crew, K.D., Bradshaw, P.T., Santella, R.M., Steck, S.E., Sirosh, I., Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk (2015) Cancer Causes Control, 26 (2), pp. 187-203. , 25421379; Scazzone, C., Agnello, L., Ragonese, P., Lo Sasso, B., Bellia, C., Bivona, G., Association of CYP2R1 rs10766197 with MS risk and disease progression (2018) J. Neurosci. Res., 96 (2), pp. 297-304. , 28834557; Scragg, R., Jackson, R., Holdaway, I.M., Lim, T., Beaglehole, R., Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: A community-based study (1990) Int. J. Epidemiol., 19 (3), pp. 559-563. , 2262248; Sedky, N., Rahman, M., Hassanein, S., Gad, M., Genetic variants of CYP2R1 are key regulators of serum vitamin D levels and incidence of myocardial infarction in middle-aged Egyptians (2018) Curr. Pharmaceut. Biotechnol., 19 (3), pp. 265-273; Shen, H., Bielak, L.F., Ferguson, J.F., Streeten, E.A., Yerges-Armstrong, L.M., Liu, J., Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification (2010) Arterioscler. Thromb. Vasc. Biol., 30 (12), pp. 2648-2654. , 20847308; Simon, K.C., Munger, K., Kraft, P., Hunter, D., de Jager, P., Ascherio, A., Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis (2011) J. Neurol., 258 (9), p. 1676. , 21431378; Sundqvist, E., B��rnhielm, M., Alfredsson, L., Hillert, J., Olsson, T., Kockum, I., Confirmation of association between multiple sclerosis and CYP27B1 (2010) Eur. J. Hum. Genet., 18 (12), pp. 1349-1352. , 20648053; Wang, P., Zhang, H., Zhang, Z., Qin, L., Li, B., Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: A meta-analysis (2015) Onco Targets Ther, 8, p. 1175. , 26045671; Zhao, Z., Winget, M., Economic burden of illness of acute coronary syndromes: Medical and productivity costs (2011) BMC Health Serv. Res., 11 (1). , 21314995
dcterms.sourceScopus

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
avatar_scholar_256.png
Size:
6.31 KB
Format:
Portable Network Graphics
Description:
Download

Collections

Faculty Of Pharmacy Research Paper