Mean platelet volume: An immanent predictor of subclinical atherosclerosis in psoriatic patients compared with interleukin-1? and interleukin-6

Simple item page
dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarag A.G.A.
dc.contributor.authorZytoon A.A.
dc.contributor.authorHabib M.S.
dc.contributor.authorElnaidany N.F.
dc.contributor.authorIbrahem R.A.L.
dc.contributor.authorSalman S.
dc.contributor.authorMahfouz R.Z.
dc.contributor.otherDepartment of Dermatology
dc.contributor.otherAndrology and STDs
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El-Kom
dc.contributor.otherMenoufia Governorate
dc.contributor.other23511
dc.contributor.otherEgypt; Department of Radiology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherEgypt; Department of Medical Biochemistry
dc.contributor.otherFaculty of Medicine
dc.contributor.otherEgypt; Public Health and Community Medicine
dc.contributor.otherFaculty of Medicine
dc.contributor.otherEgypt; Department of Clinical Pathology
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El-Kom
dc.contributor.otherMenoufia Governorate
dc.contributor.otherEgypt; Department of Clinical Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Sciences and Arts University
dc.contributor.other6th of October City
dc.contributor.otherGiza Governorate
dc.contributor.otherEgypt; Hematology and Oncology Research
dc.contributor.otherCleveland Clinic Lerner College of Medicine (CCLCM)
dc.contributor.otherCase Western University
dc.contributor.otherCleveland
dc.contributor.otherOH
dc.contributor.otherUnited States
dc.date.accessioned2020-01-09T20:40:55Z
dc.date.available2020-01-09T20:40:55Z
dc.date.issued2018
dc.descriptionScopus
dc.description.abstractBackground Mean platelet volume (MPV), may help to determine atherosclerosis threat. Cardiovascular disease is one of the common causes of morbidity and mortality in patients having psoriasis. Objective To examine MPV as a biomarker for subclinical atherosclerosis in psoriasis patients, compared with interleukin (IL)-1?, IL-6, and carotid intima media thickness (CIMT). Patients and methods Psoriatic patients (n=70) and age-matched and sex-matched healthy controls (n=60) were enrolled. Psoriasis Area and Severity Index score was used to assess psoriasis severity. For all enrolled participants; evaluation of MPV, IL-1?, and IL-6 serum levels, and measuring of CIMT were done. Results The mean values of MPV, IL-1, IL-6, and CIMT, all were significantly elevated in psoriatic patients than controls (P<0.05 for all). They were significantly correlated with each other (P<0.001), and with severity of psoriasis. Receiver operating characteristic curve analysis showed the possible validity of MPV for detection of subclinical atherosclerosis in psoriatic patients (sensitivity=90.9%, specificity=61.5%, accuracy=80%, area under the curve=0.82, P<0.001, 95% confidence interval=0.71-92) with 8.95 fl/ml as a cutoff value. Conclusion MPV is a good sensitive test for early prediction of atherosclerosis in psoriatic patients. We recommend a follow-up large scale study on psoriasis to examine the use of antiplatelets. � 2018 Egyptian Women's Dermatologic Society.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100465128&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1097/01.EWX.0000532719.31339.7c
dc.identifier.doiPubMed ID :
dc.identifier.issn16871537
dc.identifier.otherhttps://doi.org/10.1097/01.EWX.0000532719.31339.7c
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/MXM7Z
dc.language.isoEnglishen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofseriesJournal of the Egyptian Women's Dermatologic Society
dc.relation.ispartofseries15
dc.subjectatherosclerosisen_US
dc.subjectcarotid intima media thicknesen_US
dc.subjectinterleukin-1en_US
dc.subjectinterleukin-6en_US
dc.subjectmean platelet volumeen_US
dc.subjectpredictive biomarkeren_US
dc.subjectpsoriasisen_US
dc.subjectbiological markeren_US
dc.subjectinterleukin 1alphaen_US
dc.subjectinterleukin 6en_US
dc.subjectadulten_US
dc.subjectarterial wall thicknessen_US
dc.subjectArticleen_US
dc.subjectatherosclerosisen_US
dc.subjectclinical examinationen_US
dc.subjectcontrolled studyen_US
dc.subjectdiagnostic accuracyen_US
dc.subjectfemaleen_US
dc.subjectfollow upen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmean platelet volumeen_US
dc.subjectmeasurementen_US
dc.subjectonset ageen_US
dc.subjectprognosisen_US
dc.subjectprotein blood levelen_US
dc.subjectpsoriasisen_US
dc.subjectPsoriasis Area and Severity Indexen_US
dc.subjectreceiver operating characteristicen_US
dc.subjectsensitivity and specificityen_US
dc.subjectsubclinical atherosclerosisen_US
dc.titleMean platelet volume: An immanent predictor of subclinical atherosclerosis in psoriatic patients compared with interleukin-1? and interleukin-6en_US
dc.typeArticleen_US
dcterms.isReferencedByNeneman, A., Adamski, Z., Clinical and epidemiological systemic disorders in psoriasis patients (2009) Forum Med Rodz, 3, pp. 447-453; Michalek, I.M., Loring, B., John, S.M., A systematic review of worldwide epidemiology of psoriasis (2017) J Eur Acad Dermatol Venereol, 31, pp. 205-212; Kalkan, G., Karadag, A.S., The association between psoriasis and cardiovascular diseases (2013) Eur J Gen Med, 10, p. 12; Dowlatshahi, E.A., Vander Voort, E.A., Arends, L.R., Nijsten, T., Markers of systemic inflammation in psoriasis: A systematic review and meta-analysis (2013) Br J Dermatol, 169, pp. 266-282; Rocha-Pereira, P., Santos-Silva, A., Rebelo, I., Figueiredo, A., Quintanilha, A., Teixeira, F., The inflammatory response in mild and in severe psoriasis (2004) Br J Dermatol, 150, pp. 917-928; Boehncke, W.H., Perspective: Don't be superficial (2012) Nature, 492, p. S55; Arican, O., Aral, M., Sasmaz, S., Ciragil, P., Serum levels of TNF-alpha, IFNgamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity (2005) Mediators Inflamm, 2005, pp. 273-279; Irimie, M., Oanta, A., Irimie, C.A., Fekete, L.G., Minea, D.I., Pascu, A., Cardiovascular risk factors in patients with chronic plaque psoriasis: A case-control study on the Brasov County population (2015) Acta Dermatovenerol Croat, 23, pp. 28-35; Ghazizadeh, R., Shimizu, H., Tosa, M., Ghazizadeh, M., Pathogenic mechanisms shared between psoriasis and cardiovascular disease (2010) J Med Sci, 7, pp. 284-289; Tamagawa-Mineoka, R., Katoh, N., Kishimoto, S., Platelet activation in patients with psoriasis: Increased plasma levels of platelet-derived microparticles and soluble P-selectin (2010) J Am Acad Dermatol, 62, pp. 621-626; Mehta, N.N., Yu, Y., Pinnelas, R., Krishnamoorthy, P., Shin, D.B., Troxel, A.B., Gelfand, J.M., Attributable risk estimate of severe psoriasis on major cardiovascular events (2011) Am J Med, 124, pp. 775-776; Von Hundelshausen, P., Weber, C., Platelets as immune cells: Bridging inflammation and cardiovascular disease (2007) Circ Res, 100, pp. 27-40; Leader, A., Pereg, D., Lishner, M., Are platelet volume indices of clinical use? A multidisciplinary review (2012) Ann Med, 44, pp. 805-816; Kim, D.S., Lee, J., Kim, S.H., Kim, S.M., Lee, M.G., Mean platelet volume is elevated in patients with psoriasis vulgaris (2015) Yonsei Med J, 56, pp. 712-718; Tekbas, E., Kara, A.F., Ariturk, Z., Cil, H., Islamoglu, Y., Elbey, M.A., Mean platelet volume in predicting short-and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarction (2011) Scand J Clin Lab Invest, 71, pp. 613-619; Thornton, P., McColl, B.W., Greenhalgh, A., Denes, A., Allan, S.M., Rothwell, N.J., Platelet interleukin-1alpha drives cerebrovascular inflammation (2010) Blood, 115, pp. 3632-3639; Gremmel, T., Perkmann, T., Kopp, C.W., Seidinger, D., Eichelberger, B., Koppensteiner, R., Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation (2015) PLoS One, 10, p. e0122586; Elsheikh, R.G., Amin, T., El-Ashmawy, A.A., Abdalla, S.I., Evaluation of subclinical atherosclerosis in Egyptian psoriatic patients (2014) J Saudi Heart Assoc, 26, pp. 63-71; Kuek, A., Hazleman, B.L., Ostor, A.J., Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: A medical revolution (2007) Postgraduate Med J, 83, pp. 251-260; Jin, Y., Zhang, F., Yang, S., Kong, Y., Xiao, F., Hou, Y., Combined effects of HLA-Cw6, body mass index and waist-hip ratio on psoriasis vulgaris in Chinese Han population (2008) J Dermatol Sci, 52, pp. 123-129; Van Kerkhof, P., Schalkwijk, J., Psoriasis (2008) Dermatology, pp. 115-148. , Bolognia J, Jorizzo J, Rapini R, editors. London, UK: Mosby; Schmitt, J., Wozel, G., The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis (2005) Dermatology, 210, pp. 194-199; Diehl, S.R., Wang, Y., Brooks, C.N., Burmeister, J.A., Califano, J.V., Wang, S., Schenkein, H.A., Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis (1999) J Periodontol, 70, pp. 418-430; Chung, H.W., Seo, J.S., Hur, S.E., Kim, H.L., Kim, J.Y., Jung, J.H., Association of interleukin-6 promoter variant with bone mineral density in premenopausal women (2003) J Human Genet, 48, pp. 243-248; Gasparyan, A.Y., Ayvazyan, L., Mikhailidis, D.P., Kitas, G.D., Mean platelet volume: A link between thrombosis and inflammation? (2011) Curr Pharm des, 17, pp. 47-58; Canpolat, F., Akpinar, H., Eskioglu, F., Mean platelet volume in psoriasis and psoriatic arthritis (2010) Clin Rheumatol, 29, pp. 325-328; Saleh, H.M., Attia, E.A., Onsy, A.M., Saad, A.A., Abd Ellah, M.M., Platelet activation: A link between psoriasis per se and subclinical atherosclerosis-A case-control study (2013) Br J Dermatol, 169, pp. 68-75; Banska-Kisiel, K., Haberka, M., Bergler-Czop, B., Brzezinska-Wcislo, L., Okopien, B., Gasior, Z., Carotid intima-media thickness in patients with mild or moderate psoriasis (2016) Postepy Dermatol Alergol, 33, pp. 286-289; El-Mongy, S., Fathy, H., Abdelaziz, A., Omran, E., George, S., Neseem, N., El-Nour, N., Subclinical atherosclerosis in patients with chronic psoriasis: A potential association (2010) J Eur Acad Dermatol Venereol, 24, pp. 661-666; Yilmazer, B., Sahin, T., Unlu, B.O., Kir, H.M., Cefle, A., Investigation of subclinical atherosclerosis in psoriatic arthritis patients with minimal disease activity (2015) Rheumatol Int, 35, pp. 1385-1392; Enany, B., El Zohiery, A.K., Elhilaly, R., Badr, T., Carotid intima-media thickness and serum leptin in psoriasis (2012) Herz, 37, pp. 527-533; Kimhi, O., Caspi, D., Bornstein, N.M., Maharshak, N., Gur, A., Arbel, Y., Prevalence and risk factors of atherosclerosis in patients with psoriatic arthritis (2007) Semin Arthritis Rheum, 36, pp. 203-209; Boos, C.J., Balakrishnan, B., Lip, G.Y., The effects of coronary artery disease severity on time-dependent changes in platelet activation indices in stored whole blood (2008) J Thromb Thrombolysis, 25, pp. 135-140; Kamath, S., Blann, A.D., Lip, G.Y., Platelet activation: Assessment and quantification (2001) Eur Heart J, 22, pp. 1561-1571; Prens, E.P., Benne, K., Van Damme, J., Bakkus, M., Brakel, K., Benner, R., Van Joost, T., Interleukin-1 and interleukin-6 in psoriasis (1990) J Invest Dermatol, 95, pp. 121s-124s; Oliveira, P.S., Cardoso, P.R., Lima, E.V., Pereira, M.C., Duarte, A.L., Pitta, R., IL-17A, IL-22, IL-6, and IL-21 serum levels in plaque-type psoriasis in Brazilian patients (2015) Mediators Inflamm, 2015, p. 819149; Crome, S., Wang, A., Levings, M., Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease (2010) Clin Exp Immunol, 159, pp. 109-119; Bou-Dargham, M.J., Khamis, Z.I., Cognetta, A.B., Sang, Q.A., The role of interleukin-1 in inflammatory and malignant human skin diseases and the rationale for targeting interleukin-1 alpha (2017) Med Res Rev, 37, pp. 180-216; Weber, A., Wasiliew, P., Kracht, M., Interleukin-1 (IL-1) pathway (2010) Sci Signal, 3, p. cm1; Krumm, B., Xiang, Y., Deng, J., Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses (2014) Protein Sci, 23, pp. 526-538; Hansson, G.K., Inflammation, atherosclerosis, and coronary artery disease (2005) N Engl J Med, 352, pp. 1685-1695
dcterms.sourceScopus

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
avatar_scholar_128.png
Size:
2.73 KB
Format:
Portable Network Graphics
Description:
Download
Thumbnail Image
Name:
Mean_platelet_volume___an_immanent_predictor_of.5.pdf
Size:
391.14 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Faculty Of Pharmacy Research Paper