FORMULATION AND EVALUATION OF DORZOLAMIDE AND TIMOLOL OCUSERTS
Date
2017-02
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
INT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCH
Series Info
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH;Volume: 8 Issue: 2 Pages: 915-924
Doi
Scientific Journal Rankings
Abstract
Objective: This study aims to formulate novel dorzolamide hydrochloride and timolol maleate ocuserts to enhance patient compliance through providing controlled drugs release from polymeric matrix. Methods: Ocuserts were prepared by solvent-casting method using different polymers Ethyl Cellulose, Eudragit S100 and Hydroxy propyl methyl cellulose in different ratios. The prepared ocusters were physcochemichally evaluated for their weight, thickness, drug content uniformity, surface pH, Swelling Index (SI) and folding endurance. In-vitro drug release was studied from the prepared formulas and the results were analyzed by drug release kinetic models. The ocuserts stability after three month's storage at 40 +/- 0.5 degrees C and 75 +/- 5% RH was estimated. In-vivo tests were done to study the release profile and estimate the safety of the incorporated drugs in rabbits' eyes. Results: The prepared ocuserts show uniform weight, thickness and drug content. Their surface pH was in the physiological range and showed acceptable folding endurance. HPMC Formulas had higher SI values. Results of in-vivo testing for one of the prepared ocuserts shows slow release of both drugs up to 24 hours with no signs of eye sensitivity. Conclusion: One of the prepared ocuserts is promising for once-daily effective and safe drug delivery system of DHCL and TM for glaucoma treatment.
Description
Accession Number: WOS:000397033500056
Keywords
DELIVERY, RELEASE, OCULAR INSERTS, GLAUCOMA TREATMENT, Ethyl Cellulose, Glucoma, Dorzolamide Hydrochloride, Timolol Maleate, Ocusert
Citation
Formulation and evaluation of Controlled release ocular inserts of betaxolol hydrochloride. By: Ashture, AKA; Patil, A; Joshi, A. IOSR Journal of Parmacy Volume: 2 Issue: 5 Pages: 34-8 Published: 2012 Times Cited: 1 2. FORMULATION AND EVALUATION OF PROGRAMMED RELEASE OCULAR INSERTS OF MIZOLASTINE By: Bansal, Hema; Khatry, Sadhna; Arora, Sandeep INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH Volume: 4 Issue: 1 Pages: 497-501 Published: JAN 2013 Times Cited: 1 3. Formulation Design and In vitro-In vivo Evaluation of Moxifloxacin Ophthalmic Insert By: Bhabani, SN; Suresh, C P; Suprava, S; et al. American Journal of Phytomedicine and Clinical Therapeutics Volume: 3 Issue: 4 Pages: 302-312 Published: 2015 [Show additional data] Times Cited: 1 4. Formation of the aqueous humor: Transport components and their integration By: Civan, Mortimer M. EYE'S AQUEOUS HUMOR, EDITION 2 Book Series: Current Topics in Membranes Volume: 62 Pages: 1-45 Published: 2008 Times Cited: 11 5. Modeling and comparison of dissolution profiles By: Costa, P; Manuel, J; Lobo, S EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Volume: 13 Issue: 2 Pages: 123-133 Published: MAY 2001 Times Cited: 2,808 6. Title: [not available] By: Dale. Ophthalmic Preparations, Volume: 39 Issue: 5 Published: Sept.-Oct. 2013 Publisher: USP Times Cited: 1 7. Design and evaluation of esmolol hydrochloride ocular inserts with special reference to glaucoma treatment (View record in BIOSIS Citation Index) By: Dave, Vivek; Sharma, Swapnil; Paliwal, Sarvesh Journal of Pharmaceutical Investigation Volume: 43 Issue: 2 Pages: 89-99 Published: APR 2013 Times Cited: 2 8. Controlled release polymeric ocular delivery of acyclovir By: Deshpande, Praful Balavant; Dandagi, Panchaxari; Udupa, Nayanabhirama; et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY Volume: 15 Issue: 4 Pages: 369-378 Published: JUL-AUG 2010 Times Cited: 17 9. Title: [not available] By: Dollery, CT. Therapeutic drugs Published: 1999 Publisher: Churchill Livingstone, Edinburgh Times Cited: 251 10. Managing adverse effects of glaucoma lengmedications By: Inoue, Kenji CLINICAL OPHTHALMOLOGY Volume: 8 Pages: 903-913 Published: 2014 Times Cited: 27 11. Formulation and Evaluation of Buccal Film of Glimepiride By: Jadhav, KR; Pawar, AY; Nile, AS. Pharma Science Monitor Volume: 5 Issue: 3 Pages: 278-292 Published: 2014 Times Cited: 1 12. Drug release characteristics of dosage forms: a review (View record in BIOSIS Citation Index) By: Kakar, Satinder; Singh, Ramandeep; Semwal, Alok Journal of Coastal Life Medicine Volume: 2 Issue: 4 Pages: 332-336 Published: APR 2014 Times Cited: 3 13. Alginate inserts loaded with epidermal growth factor for the treatment of keratoconjunctivitis sicca By: Koelwel, Christoph; Rothschenk, Stefan; Fuchs-Koelwel, Barbara; et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY Volume: 13 Issue: 3 Pages: 221-231 Published: 2008 Times Cited: 11 14. MECHANISMS OF SOLUTE RELEASE FROM POROUS HYDROPHILIC POLYMERS By: KORSMEYER, RW; GURNY, R; DOELKER, E; et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS Volume: 15 Issue: 1 Pages: 25-35 Published: 1983 Times Cited: 2,557 15. DESIGN AND OPTIMIZATION OF CONTROLLED RELEASE OCULAR INSERTS OF DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE FOR TREATMENT OF GLAUCOMA By: Manjunatha, K. M.; Kulkarni, G. T.; Ismail, Md. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH Volume: 3 Issue: 10 Pages: 3915-3922 Published: OCT 2012 Times Cited: 4 16. In vitro and In vivo Evaluation of Timolol Maleate Ocular Inserts Using Different Polymers By: Mohamed, AAS; Mai, AHR. J Clin Exp Ophthalmol Pages: 3-8 Published: 2012 Times Cited: 1 17. Formulation and In-vitro Characterization of Sustained Release Matrix Type Ocular Timolol Maleate Mini-Tablet By: Mortazavi, Seyed Alireza; Jafariazar, Zahra; Ghadjahani, Yasaman; et al. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH Volume: 13 Issue: 1 Pages: 19-27 Published: WIN 2014 Times Cited: 5 18. Hydrophilic Matrices for Oral Control Drug Delivery By: Muhammad, UG; Barbara, RC. American Journal of Pharmacological Sciences Volume: 3 Issue: 5 Pages: 103-109 Published: 2015 Times Cited: 1 19. Formulation and Evaluation of Erodible Ocular Films of Valacyclovir Hydrochloride. By: Naga, PKR; Sayani, B; Ramesh, BP. J. Pharm. Sci Volume: 13 Issue: 1 Pages: 75-81 Published: 2014 Times Cited: 1 20. Method Development and Its Validation for Simultaneous Estimation of Timolol Maleate and Dorzolamide Hydrochloride in as API and In Ophthalmic Solution Dosage Form by RPHPLC By: Nagoria, BP; Muysunic, P; Guptad, S. Journal of Chemical and Pharmaceutical Research Pages: 866-74 Published: 2011 Times Cited: 12 21. Formulation and Evaluation of Fast Dissolving Oral Film of Bisoprolol Fumarate By: Padamwar, AP; Phasate, PP. International Journal of Pharma Sciences and Research Volume: 6 Issue: 1 Pages: 135-142 Published: 2015 Times Cited: 1 22. Polymeric films as a promising carrier for bioadhesive drug delivery: Development, characterization and optimization By: Pallavi, B; Gurpreet, K. Saudi Pharmaceutical Journal Published: 2015 Times Cited: 1 23. Ophthalmic Drug Delivery system- A Review By: Patel, H.A.; Patel, J.K.; Patel, K.N.; et al. Der Pharmacia Lettre Volume: 2 Issue: 4 Pages: 100-15 Published: 2010 [Show additional data] Times Cited: 11 24. Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin By: Qi, Hongyi; Chen, Wenwen; Huang, Chunyan; et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS Volume: 337 Issue: 1-2 Pages: 178-187 Published: JUN 7 2007 Times Cited: 128 25. The number of people with glaucoma worldwide in 2010 and 2020 By: Quigley, HA; Broman, AT BRITISH JOURNAL OF OPHTHALMOLOGY Volume: 90 Issue: 3 Pages: 262-267 Published: MAR 2006 Times Cited: 3,347 26. A new solution for a chronic problem; Aqueous enteric coating By: Rafati, Hasan; Ghassempour, Alireza; Barzegar-Jalali, Mohammad JOURNAL OF PHARMACEUTICAL SCIENCES Volume: 95 Issue: 11 Pages: 2432-2437 Published: NOV 2006 Times Cited: 5 27. Preparation and evaluation of ocular inserts containing norfloxacin By: Rao, MV; Shyale, S. Turkish Journal of Medical Sciences Volume: 34 Issue: 4 Pages: 239-46 Published: 2004 Times Cited: 1 28. Topical Drug Therapy in Glaucoma By: Resch, Hemma; Garhofer, Gerhard WIENER MEDIZINISCHE WOCHENSCHRIFT Volume: 156 Issue: 17-18 Pages: 501-507 Published: SEP 2006 Times Cited: 3 29. Global data on visual impairment in the year 2002 By: Resnikoff, S; Pascolini, D; Etya'ale, D; et al. BULLETIN OF THE WORLD HEALTH ORGANIZATION Volume: 82 Issue: 11 Pages: 844-851 Published: NOV 2004 Times Cited: 2,331 30. Ocular insert of Timolol Maleate using naturally occurring biodegradable polymer By: Revathy, VN. Journal of Chemical and Pharmaceutical Research Volume: 7 Issue: 7 Pages: 476-85 Published: 2015