Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Feky G.S.
dc.contributor.authorSharaf S.S.
dc.contributor.authorEl Shafei A.
dc.contributor.authorHegazy A.A.
dc.contributor.otherPharmaceutical Technology Department
dc.contributor.otherNational Research Center
dc.contributor.otherDokki
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherEgypt; Textile Research Division
dc.contributor.otherNational Research Center
dc.contributor.otherDokki
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:23Z
dc.date.available2020-01-09T20:41:23Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractBurn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. In the present study, a dressing coated with silver sulfadiazine (SSD) loaded chitosan nanoparticles (CSNPs) for the controlled-release of SSD into burn wound to control bacterial growth was investigated. CSNPs were formulated with different concentrations of chitosan and CM-?-CD and loaded with SSD complexed in 1:1 molar ratio with CM-?-CD, CSNPs were assessed for their particle size, polydispersity index, morphology and association efficiency. The formula showing the best characteristics was selected for the preparation of SSD loaded CSNPs wound dressing through a padding process with/without the use of cross-linker. The dressing was characterized for its physical properties, in addition, FTIR, X-ray, SEM and in vitro release were used for characterization. The dressing was proven effective for the inhibition of the growth of Gram positive and Gram negative bacteria as well as candida on an infected wound. 2016 Elsevier Ltden_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=25801&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2016.11.054
dc.identifier.doiPubMed ID 28024533
dc.identifier.issn1448617
dc.identifier.otherhttps://doi.org/10.1016/j.carbpol.2016.11.054
dc.identifier.otherPubMed ID 28024533
dc.identifier.urihttps://t.ly/ZK57B
dc.language.isoEnglishen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofseriesCarbohydrate Polymers
dc.relation.ispartofseries158
dc.subjectChitosan nanoparticlesen_US
dc.subjectSilver sulfadiazineen_US
dc.subjectWound dressingen_US
dc.subjectBacteriaen_US
dc.subjectChitinen_US
dc.subjectChitosanen_US
dc.subjectMicroorganismsen_US
dc.subjectNanoparticlesen_US
dc.subjectParticle sizeen_US
dc.subjectAssociation efficiencyen_US
dc.subjectBacterial growthen_US
dc.subjectChitosan nanoparticlesen_US
dc.subjectControlled releaseen_US
dc.subjectGram-negative bacteriaen_US
dc.subjectPolydispersity indicesen_US
dc.subjectSilver sulfadiazinesen_US
dc.subjectWound dressingsen_US
dc.subjectSilveren_US
dc.subjectantifungal agenten_US
dc.subjectchitosanen_US
dc.subjectdrug carrieren_US
dc.subjectnanoparticleen_US
dc.subjectsulfadiazine silveren_US
dc.subjectbandageen_US
dc.subjectchemistryen_US
dc.subjectAntifungal Agentsen_US
dc.subjectBandagesen_US
dc.subjectChitosanen_US
dc.subjectDrug Carriersen_US
dc.subjectNanoparticlesen_US
dc.subjectSilver Sulfadiazineen_US
dc.titleUsing chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressingen_US
dc.typeArticleen_US
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