Utilizing of 4-(benzothiazol-2-yl)phenylamine as a precursor of bioactive agents
Date
2012
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Organic CHEMISTRY
Series Info
Organic CHEMISTRY;Volume 8 Issue 9
Doi
Scientific Journal Rankings
Abstract
Several heterocyclic compounds show either anticancer or antimicrobial
activity, the intial goal of this study was directed towards combining some
of those heterocyclic moieties- that have either activity- together to test
whether the newly formed compounds will demonstrate both activity or
one activity will predominate over the other or both activity will deminish.
This was accomplished via Scheme 1 and Scheme 2 where diazotization of
4-(benzothiazol-2-yl)phenylamine 1 followed by reacting this functionalized
hydrazone with a variety of binucleophiles to give the key intermediates
that reacted with amino reagents viz. hydrazine, urea or thiourea to yield
some of the goal compounds (Scheme 1). Reacting compound 1with carbonyl
or isothiocyanate reagents followed by cyclization of the given key
intermediates afforeded a set of novel target compounds (Scheme 2). These
final compunds were tested for in vitro antimicrobial and anticancer activity.
Two compounds showed both antimicrobial and anticancer activity
while the other compounds were highly active either as antimicrobial only
or as anticancer only.
Description
Keywords
benzothiazol, phenylamine, Pharmacophores, Anticancer, Antimicrobial, Improving chemotherapy regimen design
Citation
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