The reaction of cyanoacetic acid hydrazide with 2-acetylfuran: Synthesis of coumarin, pyridine, thiophene and thiazole derivatives with potential antimicrobial activities
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Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Series Info
Scientia Pharmaceutica
77
77
Scientific Journal Rankings
Abstract
The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2-10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs. � Mohareb et al.; licensee �sterreichische Apotheker-Verlagsgesellschaft m. b. H.
Description
Scopus
Keywords
Antimicrobial, Pyridine, Thiazole, Thiophene, 2 cyano n '(1 furan 2 ylethylidene) 3 (4 methoxyphenyl)prop 2 enehydrazide, 2 cyano n (1 furan 2 ylethylidene) 3 phenylprop 2 enehydrazide, 2 cyano n' (1 furan 2 ylethylidene) 2 (phenylhydrazono)acetohydrazide, 2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methoxyphenyl)hydrazono]acetohydrazide, 2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methylphenyl)hydrazono]acetohydrazide, 3 (4 chlorophenyl) 2 cyano n' (1 furan 2 ylethylidene)prop 2 enehydrazide, 3 amino n' (1 furan 2 ylethylidene) 4,5,6,7 tetrahydro 1 benzothiophene 2 carbohydrazide, 3,5 diamino 4 cyano n' (1 furan 2 ylethylidene)thiophene 2 carbohydrazide, 4 amino n' (1 furan 2 ylethylidene) 3 phenyl 2 thioxo 2,3 dihydro 1,3 thiazole 5 carbohydrazide, 4,6 diamino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 1,2 dihydropyridine 3 carbonitrile, 6 amino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 4 phenyl 1,2 dihydropyridine 3,5 dicarbonitrile, acetic acid derivative, ampicillin, antiinfective agent, coumarin derivative, cycloheximide, ethyl 2 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 4 phenyl 1,6 dihydropyridine 3 carboxylate, ethyl 2,4 diamino 5 [[2 (1 furan 2 ylethylidene)hydrazino]carbonyl]thiophene 3 carboxylic acid, ethyl 4 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 1,6 dihydropyridine 2 carboxylic acid, furan derivative, hydrazide derivative, hydrazone derivative, n' (1 furan 2 ylethylidene) 2 oxo 2h chromene 3 carbohydrazide, pyridine derivative, thiazole derivative, thiophene derivative, unclassified drug, antimicrobial activity, article, Bacillus cereus, Bacillus subtilis, Caenorhabditis elegans, chemical reaction, controlled study, drug synthesis, Escherichia coli, minimum inhibitory concentration, nonhuman