LC simultaneous determination of thioctic acid, benfotiamine and cyanocobalamin in thiotacid compound capsules

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSalem H.
dc.contributor.otherAnalytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:33Z
dc.date.available2020-01-25T19:58:33Z
dc.date.issued2010
dc.descriptionScopus
dc.description.abstractA simple, selective, sensitive, precise, simultaneous liquid chromatographic analysis of capsules containing thioctic acid, benfotiamine and cyanocobalamin was described. Good chromatographic separation was achieved using a Zorbax C18 (4.6 cm � 250 mm, 5 ?m) and a mobile phase consisting of acetonitrile-phosphate buffer pH 3.5 (15:85, v/v) at a flow rate of 0.9 mL min-1. The ultraviolet detector was set a wavelength of 280 nm. Thioctic acid, benfotiamine and cyanocobalamin were eluted at 2.869, 3.752 and 13.689 min, respectively. The linear ranges for thioctic acid, benfotiamine and cyanocobalamin were 30-180, 4-24 and 0.025-0.150 ?g mL-1, respectively. The recoveries of thioctic acid, benfotiamine and cyanocobalamine in pharmaceutical preparation were all greater than 98% and their relative standard deviations were less than 2.0%. The limits of detection were 2.57, 0.19 and 0.003 ?g mL-1 for thioctic acid, benfotiamine and cyanocobalamin, respectively. � 2010 Vieweg+Teubner Verlag | Springer Fachmedien Wiesbaden GmbH.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23963&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1365/s10337-010-1635-5
dc.identifier.doiPubMed ID :
dc.identifier.issn95893
dc.identifier.otherhttps://doi.org/10.1365/s10337-010-1635-5
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/rx7Pv
dc.language.isoEnglishen_US
dc.relation.ispartofseriesChromatographia
dc.relation.ispartofseries72
dc.subjectColumn liquid chromatographyen_US
dc.subjectPolyneuropathy medicamentsen_US
dc.subjectacetonitrileen_US
dc.subjectbenfotiamineen_US
dc.subjectcyanocobalaminen_US
dc.subjectphosphate buffered salineen_US
dc.subjectthioctic aciden_US
dc.subjectaccuracyen_US
dc.subjectarticleen_US
dc.subjectelutionen_US
dc.subjectflow rateen_US
dc.subjectliquid chromatographyen_US
dc.subjectpHen_US
dc.subjectpriority journalen_US
dc.subjectsensitivity analysisen_US
dc.subjectseparation techniqueen_US
dc.titleLC simultaneous determination of thioctic acid, benfotiamine and cyanocobalamin in thiotacid compound capsulesen_US
dc.typeArticleen_US
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