Human cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patients

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Shinawi, Mohamed
dc.contributor.authorTaha Mohamed, Hossam
dc.contributor.authorA. El-Ghonaimy, Eslam
dc.contributor.authorTantawy, Marwa
dc.contributor.authorYounis, Amal
dc.contributor.authorJ. Schneider, Robert
dc.contributor.authorMostafa Mohamed, Mona
dc.date.accessioned2020-02-29T08:18:52Z
dc.date.available2020-02-29T08:18:52Z
dc.date.issued2013
dc.descriptionMSA Google Scholaren_US
dc.description.abstractHuman Cytomegalovirus (HCMV) is an endemic herpes virus that re-emerges in cancer patients enhancing oncogenic potential. Recent studies have shown that HCMV infection is associated with certain types of cancer morbidity such as glioblastoma. Although HCMV has been detected in breast cancer tissues, its role, if any, in the etiology of specific forms of breast cancer has not been investigated. In the present study we investigated the presence of HCMV infection in inflammatory breast cancer (IBC), a rapidly progressing form of breast cancer characterized by specific molecular signature. We screened for anti-CMV IgG antibodies in peripheral blood of 49 non-IBC invasive ductal carcinoma (IDC) and 28 IBC patients. In addition, we screened for HCMV-DNA in postsurgical cancer and non-cancer breast tissues of non-IBC and IBC patients. We also tested whether HCMV infection can modulate the expression and activation of transcriptional factor NF-κB/p65, a hallmark of IBC. Our results reveal that IBC patients are characterized by a statistically significant increase in HCMV IgG antibody titers compared to non-IBC patients. HCMV-DNA was significantly detected in cancer tissues than in the adjacent non-carcinoma tissues of IBC and IDC, and IBC cancer tissues were significantly more infected with HCMV-DNA compared to IDC. Further, HCMV sequence analysis detected different HCMV strains in IBC patients tissues, but not in the IDC specimens. Moreover, HCMV-infected IBC cancer tissues were found to be enhanced in NF-κB/p65 signaling compared to non-IBC patients. The present results demonstrated a correlation between HCMV infection and IBC. Etiology and causality of HCMV infection with IBC now needs to be rigorously examined.en_US
dc.description.sponsorshipPublic Library of Scienceen_US
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dc.identifier.urihttps://t.ly/R0qOZ
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofseriesPloS one;Volume: 8 Issue: 2
dc.subjectUniversity of Human cytomegalovirus infectionen_US
dc.subjectBreast Cancer Patientsen_US
dc.titleHuman cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patientsen_US
dc.typeArticleen_US

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