Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status?

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarag A.G.A.
dc.contributor.authorShoiab M.A.
dc.contributor.authorSamaka R.
dc.contributor.authorAbdou A.G.
dc.contributor.authorElnaidany N.F.
dc.contributor.authorMansour A.O.M.
dc.contributor.otherDepartment of Dermatology
dc.contributor.otherAndrology and STDs
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherShibin El-Kom
dc.contributor.otherAl Minufya
dc.contributor.otherEgypt; Department of Pathology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherAl Minufya
dc.contributor.otherEgypt; Department of Clinical Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherOctober City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:31Z
dc.date.available2020-01-09T20:40:31Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractBackground: Second to fourth digit (2D:4D) ratio is the ratio of index to ring fingers length. It reflects prenatal androgen exposure and sensitivity. Androgens are important in the pathogenesis of acne vulgaris, This ratio may therefore be of significance in determining the expression of androgen receptors. Aim: To investigate the relationship between second to fourth digit ratio and androgen receptor expression in female patients with acne vulgaris and to assess its association with clinical aspects of acne vulgaris. Methods: Females patients (n = 352) with different degrees of acne vulgaris severity and 168 age-matched females were enrolled. Right, left and total second to fourth digit ratios were calculated. Biopsies from all participants were processed for androgen receptor expression by immunohistochemical method. Results: Right, left and total second to fourth digit ratios were significantly lower in acne vulgaris patients than controls (P < 0.001 for all), and each of them had a significant negative correlation with duration of acne vulgaris (P < 0.001; P = 0.013; P < 0.001, respectively). Androgen receptors were detected in epidermal keratinocytes, hair follicles, sebaceous glands and fibroblasts. Right second to fourth digit ratio showed a negative correlation with androgen receptor H score of keratinocytes (r = -0.28;P = 0.02), hair follicles (r = -0.22; P = 0.05) and fibroblasts (r= -0.37;P = 0.001), while left second to fourth digit ratio demonstrated negative correlation with androgen receptor H score of sebocytes (r = -0.397; P < 0.000) only. Limitations: Lack of follow-up and absence of male participants were the main limitations of this study. Conclusion: A masculine second to fourth digit ratio in female patients could anticipate acne vulgaris development, its duration and severity. Moreover, this ratio is associated with an upregulation of cutaneous androgen receptors. Taken together, second to fourth digit ratio could help in designing plans for treatment of acne vulgaris. � 2019 Medknow Publications. All rights reserved.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24836&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.4103/ijdvl.IJDVL-35-18
dc.identifier.doiPubMed ID 31249215
dc.identifier.issn3786323
dc.identifier.otherhttps://doi.org/10.4103/ijdvl.IJDVL-35-18
dc.identifier.otherPubMed ID 31249215
dc.identifier.urihttps://t.ly/1Vw2L
dc.language.isoEnglishen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofseriesIndian Journal of Dermatology, Venereology and Leprology
dc.relation.ispartofseries85
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectAcne vulgarisen_US
dc.subjectandrogen receptoren_US
dc.subjectdigit ratioen_US
dc.subjectimmunohistochemistryen_US
dc.subjectandrogen receptoren_US
dc.subjectacne vulgarisen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectclinical featureen_US
dc.subjectcontrolled studyen_US
dc.subjectcross-sectional studyen_US
dc.subjectdisease durationen_US
dc.subjectdisease severityen_US
dc.subjectfemaleen_US
dc.subjecthair follicleen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjectimmunohistochemistryen_US
dc.subjectkeratinocyteen_US
dc.subjectmajor clinical studyen_US
dc.subjectonset ageen_US
dc.subjectprotein expressionen_US
dc.subjectsebaceous cellen_US
dc.subjectsebaceous glanden_US
dc.subjectsecond-to-fourth digit ratioen_US
dc.subjectskin biopsyen_US
dc.subjectskin fibroblasten_US
dc.titleSecond to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status?en_US
dc.typeArticleen_US
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