The role of IL-28, IFN-?, and TNF-? in predicting response to pegylated interferon/ribavirin in chronic HCV patients
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Date
2015
Authors
Abdou A.G.
Asaad N.Y.
Ehsan N.
Eltahmody M.
El-Sabaawy M.M.
Elkholy S.
Elnaidany N.F.
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Blackwell Munksgaard
Series Info
APMIS
123
123
Scientific Journal Rankings
Abstract
The primary goal of HCV therapy is to achieve a sustained virological response (SVR). Many host and viral factors influence the treatment response. Cytokines play an important role in the defense against viral infections, where successful treatment of hepatitis C depends on a complex balance between pro- and anti-inflammatory responses. In the present study, we investigated the relationship between the presence and percentage of some cytokines (IL-28, IFN-?, and TNF-?) regarding different clinicopathological parameters including response to therapy in chronic HCV patients using immunohistochemical technique. This study was carried out on 64 chronic HCV patients (34 responders and 30 non-responders). Of cases, 54% showed IL-28 expression, which was associated with low AST (p�=�0.002) and low HAI score (p�=�0.006). Of cases, 67 and 45% showed IFN-? and TNF-? expression, respectively, where the median percentage of TNF-? expression was higher in grade II spotty necrosis compared to grade I. Some inflammatory cytokines expressed by intrahepatic inflammatory cells in chronic HCV patients promote inflammation and injury (pro-inflammatory) such as TNF-?. Other cytokines aid in resolving inflammation and injury (anti-inflammatory) such as IL-28. The balance between these cytokines will determine the degree of inflammatory state. None of the investigated cytokines proved its clear cut role in affecting response to therapy, however, their levels varied between responders and non-responders for further investigations to clarify. � 2014 APMIS. Published by John Wiley & Sons Ltd.
Description
Scopus
Keywords
October University for Modern Sciences and Arts, University for Modern Sciences and Arts, MSA University, جامعة أكتوبر للعلوم الحديثة والآداب, Chronic HCV, IFN?, IL-28, Immunohistochemistry, Pegylated interferon/ribavirin, Response to therapy, TNF-?, alanine aminotransferase, alpha fetoprotein, aspartate aminotransferase, gamma interferon, interleukin 28, peginterferon alpha2a, ribavirin, tumor necrosis factor alpha, virus RNA, alanine aminotransferase, alpha interferon, aspartate aminotransferase, biological marker, gamma interferon, IL28A protein, human, interleukin derivative, macrogol derivative, peginterferon alpha2a, recombinant protein, ribavirin, tumor necrosis factor alpha, adult, alanine aminotransferase blood level, Article, aspartate aminotransferase blood level, controlled study, disease association, disease severity, female, hepatitis C, human, human cell, human tissue, immunohistochemistry, inflammatory cell, lymphocyte, major clinical study, male, outcome assessment, portal vein, priority journal, protein expression, retrospective study, treatment response, blood, drug combination, Hepacivirus, Hepatitis C, Chronic, immunology, middle aged, nonparametric test, virology, young adult, Adult, Alanine Transaminase, Aspartate Aminotransferases, Biological Markers, Drug Therapy, Combination, Female, Hepacivirus, Hepatitis C, Chronic, Humans, Immunohistochemistry, Interferon-alpha, Interferon-gamma, Interleukins, Male, Middle Aged, Polyethylene Glycols, Recombinant Proteins, Retrospective Studies, Ribavirin, Statistics, Nonparametric, Tumor Necrosis Factor-alpha, Young Adult