Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorNasr T.
dc.contributor.authorBondock S.
dc.contributor.authorRashed H.M.
dc.contributor.authorFayad W.
dc.contributor.authorYouns M.
dc.contributor.authorSakr T.M.
dc.contributor.otherDepartment of Pharmaceutical Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherEgypt; Department of Pharmaceutical Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern University for Technology and Information
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherFaculty of Science
dc.contributor.otherMansoura University
dc.contributor.otherMansoura
dc.contributor.otherET-35516
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherFaculty of Science
dc.contributor.otherKing Khalid University
dc.contributor.otherAbha
dc.contributor.other9004
dc.contributor.otherSaudi Arabia; Labeled Compounds Department
dc.contributor.otherHot Labs Center
dc.contributor.otherEgyptian Atomic Energy Authority
dc.contributor.otherP.O. Code 13759
dc.contributor.otherCairo
dc.contributor.otherEgypt; Drug Bioassay-Cell Culture Laboratory
dc.contributor.otherPharmacognosy Department
dc.contributor.otherNational Research Centre
dc.contributor.otherDokki
dc.contributor.otherGiza 12622
dc.contributor.otherEgypt; Department of Biochemistry and Molecularlar Biology
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherEgypt; Radioactive Isotopes and Generators Department
dc.contributor.otherHot Laboratories Centre
dc.contributor.otherAtomic Energy Authority
dc.contributor.otherP.O. Code 13759
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University of Modern Sciences and Arts (MSA)Giza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:55Z
dc.date.available2020-01-09T20:40:55Z
dc.date.issued2018
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe current work presents the synthesis and biological evaluation of new series of coumarin hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities against resistant pancreatic carcinoma (Panc-1), hepatocellular carcinoma (HepG2) and leukemia (CCRF) cell lines using doxorubicin as reference standard. Bromocoumarin hydrazide-hydrazone derivative (BCHHD) 11b showed excellent anticancer activity against all tested cancer cell lines. Enzyme assays showed that BCHHD 11b induced apoptosis due to activation of caspases 3/7. Moreover, 11b inhibited GST and CYP3A4 in a dose dependent manner and the induced cell death could be attributed to metabolic inhibition. Moreover, 11b microarray analysis showed significant up- and down-regulation of many genes in the treated cells related to apoptosis, cell cycle, tumor growth and suppressor genes. All of the above presents BCHHD 11b as a potent anticancer agent able to overcome drug resistance. In addition, compound 11b was able to serve as a chemical carrier for 99mTc and the in vivo biodistribution study of 99mTc-11b complex revealed a remarkable targeting ability of 99mTc into solid tumor showing that 99mTc-11b might be used as a promising radiopharmaceutical imaging agent for cancer. � 2018 Elsevier Masson SASen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=17464&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.ejmech.2018.04.014
dc.identifier.doiPubMed ID 29665526
dc.identifier.issn2235234
dc.identifier.otherhttps://doi.org/10.1016/j.ejmech.2018.04.014
dc.identifier.otherPubMed ID 29665526
dc.identifier.urihttps://t.ly/52MAY
dc.language.isoEnglishen_US
dc.publisherPharmacologyonline
dc.publisherElsevier Masson SASen_US
dc.relation.ispartofseriesEuropean Journal of Medicinal Chemistry
dc.relation.ispartofseries151
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectApoptosisen_US
dc.subjectCaspases 3/7en_US
dc.subjectCoumarin hydrazide-hydrazoneen_US
dc.subjectCYP3A4en_US
dc.subjectGSTen_US
dc.subjectMicroarrayen_US
dc.subjectRadiolabelingen_US
dc.subject2 chloro 6 ethoxy 3 formylquinolineen_US
dc.subject2 oxo n' [(pyridin 3 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subject2 oxo n' [(pyridin 4 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subject6 bromo 2 oxo n' [(pyridin 3 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subject6 bromo 2 oxo n' [(pyridin 4 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subject6 bromo n (4 ethoxyphenyl) 2 oxo 2h chromene 3 carboxamideen_US
dc.subject6 bromo n' [(2 chloro 6 ethoxyquinolin 3 yl)methylene] 2 oxo 2h chromene 3 carbohydrazideen_US
dc.subject6 nitro 2 oxo n' [(pyridin 3 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subject6 nitro 2 oxo n' [(pyridin 4 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subject7 hydroxy 2 oxo n' [(pyridin 3 yl)methylene] 2h chromene 3 carbohydrazideen_US
dc.subjectamideen_US
dc.subjectantineoplastic agenten_US
dc.subjectcaspase 3en_US
dc.subjectcaspase 7en_US
dc.subjectcoumarin derivativeen_US
dc.subjectcytochrome P450 3A4en_US
dc.subjectdoxorubicinen_US
dc.subjecthydrazide derivativeen_US
dc.subjecthydrazone derivativeen_US
dc.subjectn (4 ethoxyphenyl) 2 oxo 2h chromene 3 carboxamideen_US
dc.subjectn (4 ethoxyphenyl) 6 nitro 2 oxo 2h chromene 3 carboxamideen_US
dc.subjectn (4 ethoxyphenyl) 7 hydroxy 2 oxo 2h chromene 3 carboxamideen_US
dc.subjectn (4 {[(3,4 dimethylisoxazol 4 yl)amino]sulfonyl}phenyl) 2 oxo chromene 3 carboxamideen_US
dc.subjectn (4 {[(3,4 dimethylisoxazol 4 yl)amino]sulfonyl}phenyl) 6 bromo 2 oxo chromene 3 carboxamideen_US
dc.subjectn (4 {[(3,4 dimethylisoxazol 4 yl)amino]sulfonyl}phenyl) 6 nitro 2 oxo chromene 3 carboxamideen_US
dc.subjectn' [(2 chloro 6 ethoxyquinolin 3 yl)methylene] 2 cyanoacetohydrazideen_US
dc.subjectn' [(2 chloro 6 ethoxyquinolin 3 yl)methylene] 2 oxo 2h chromene 3 carbohydrazideen_US
dc.subjectn' [(2 chloro 6 ethoxyquinolin 3 yl)methylene] 6 nitro 2 oxo 2h chromene 3 carbohydrazideen_US
dc.subjectn' [(2 chloro 6 ethoxyquinolin 3 yl)methylene] 7 hydroxy 2 oxo 2h chromene 3 carbohydrazideen_US
dc.subjectunclassified drugen_US
dc.subjectunindexed drugen_US
dc.subjectantineoplastic agenten_US
dc.subjectcoumarin derivativeen_US
dc.subjectcytochrome P450 3Aen_US
dc.subjectcytochrome P450 3A inhibitoren_US
dc.subjecthydrazone derivativeen_US
dc.subjectantiproliferative activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectcell cycleen_US
dc.subjectcontrolled studyen_US
dc.subjectdown regulationen_US
dc.subjectdrug bioavailabilityen_US
dc.subjectdrug cytotoxicityen_US
dc.subjectdrug screeningen_US
dc.subjectdrug synthesisen_US
dc.subjectenzyme activationen_US
dc.subjectenzyme assayen_US
dc.subjectHep-G2 cell lineen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectin vitro studyen_US
dc.subjectin vivo studyen_US
dc.subjectisotope labelingen_US
dc.subjectKnoevenagel condensationen_US
dc.subjectleukemiaen_US
dc.subjectliver cell carcinomaen_US
dc.subjectmetabolic inhibitionen_US
dc.subjectmicroarray analysisen_US
dc.subjectPANC-1 cell lineen_US
dc.subjectpancreas carcinomaen_US
dc.subjectpharmacokinetic parametersen_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.subjectstructure activity relationen_US
dc.subjecttumor growthen_US
dc.subjecttumor suppressor geneen_US
dc.subjectupregulationen_US
dc.subjectanimalen_US
dc.subjectchemistryen_US
dc.subjectdrug effecten_US
dc.subjecthalogenationen_US
dc.subjectmetabolismen_US
dc.subjectmouseen_US
dc.subjectneoplasmen_US
dc.subjectpathologyen_US
dc.subjectsynthesisen_US
dc.subjecttissue distributionen_US
dc.subjecttumor cell lineen_US
dc.subjectAnimalsen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectApoptosisen_US
dc.subjectCell Line, Tumoren_US
dc.subjectCoumarinsen_US
dc.subjectCytochrome P-450 CYP3Aen_US
dc.subjectCytochrome P-450 CYP3A Inhibitorsen_US
dc.subjectHalogenationen_US
dc.subjectHumansen_US
dc.subjectHydrazonesen_US
dc.subjectMiceen_US
dc.subjectNeoplasmsen_US
dc.subjectTissue Distributionen_US
dc.titleNovel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studiesen_US
dc.typeArticleen_US
dcterms.isReferencedByhttp://www.who.int/mediacentre/factsheets/fs297/en/, (Retrieved on 27 July 2016); Solyanik, G.I., (2011) Exp. Oncol., 32, pp. 181-185. , S. Vijayaraghavalu, C. Peetla, S. Lu, V. Labhasetwar, Mol. Pharm. 9(2012) 2730�2742; Tan, G., Yao, Y., Gu, Y., Li, S., Lv, M., Wang, K., Chen, H., Li, X., (2014) Bioorg. Med. Chem. Lett, 24, pp. 2825-2830; Zhao, L., Yao, Y.C., Li, S., Lv, M.J., Chen, H., Li, X.L., (2014) Bioorg. Med. Chem. Lett, 24, pp. 900-904; Chen, H., Li, S., Yao, Y.C., Zhou, L.K., Zhao, J.P., Gu, Y.J., R.Wang, K., Li, X.L., (2013) Bioorg. Med. Chem. Lett, 23, pp. 4785-4789; El-Gamal, M.I., Oh, C.H., (2014) Eur. J. Med. Chem., 84, pp. 68-76; Thakur, A., Singla, R., Jaitak, V., (2015) Eur. J. Med. Chem., 101, pp. 476-495; Emami, S., Dadashpour, S., (2015) Eur. J. Med. Chem., 102, pp. 611-630; Zhu, M., Zhou, L., Yao, Y., Li, S., Lv, M., Wang, K., Li, X., Chen, H., (2015) Med. Chem. Res., 24, pp. 2314-2324; Olomola, T.O., Klein, R., Mautsa, N., Sayed, Y., (2013) Bioorg. Med. Chem., 21, pp. 1964-1971; Patel, R.M., Patel, J.N., (2011) J. Adv. Pharm. Technol. Research� (JAPTR)�, 1, pp. 52-58; Bansal, Y., Sethi, P., Bansal, G., (2013) Med. Chem. Res., 22, pp. 3049-3060; Weigt, S., Huebler, N., Strecker, R., Braunbeck, T., Broschard, T.H., (2012) Reprod. Toxicol., 33, pp. 133-138; Nagamallu, R., Srinivasan, B., Ningappa, M.B., Kariyappa, A.K., (2016) Bioorg. Med. Chem. Lett, 26, pp. 690-694; Devji, T., Reddy, C., Woo, C., Awale, S., Kadota, S., Carrico-Moniz, D., (2011) Bioorg. Med. Chem. Lett, 21, pp. 5770-5774; Bronikowska, J., Szliszka, E., Jaworska, D., Czuba, Z.P., Krol, W., (2012) Molecules, 17, pp. 6449-6453; Nagamallu, R., Srinivasan, B., Ningappa, M.B., Kariyappa, A.K., (2016) Bioorg. Med. Chem. Lett, 26, pp. 690-694; Nasr, T., Bondock, S., Youns, M., (2014) Eur. J. Med. Chem., 76, pp. 539-548; Kamath, P.R., Sunil, D., Abdul Ajees, A., Pai, K.S.R., Das, S., (2015) Bioorg. Chem., 63, pp. 101-109; McKie, J.A., Bhagwat, S.S., Brady, H., Doubleday, M., Gayo, L., Hickman, M., Jalluri, R.K., Sutherland, M., (2004) Bioorg. Med. Chem. Lett, 14, pp. 3407-3410; Finn, G., Creaven, B., Egan, D., (2003) Eur. J. Pharmacol., 481, pp. 159-167; Wang, C.J., Hsieh, Y.J., Chu, C.Y., Lin, Y.L., Tseng, T.H., (2002) Canc. Lett., 183, pp. 163-168; Bailly, C., (2012) Chem. Rev., 112, pp. 3611-3640; Salar, U., Taha, M., Khan, K.M., Ismail, N.H., Imran, S., Perveen, S., Gul, S., Wadood, A., (2016) Eur. J. Med. Chem., 122, pp. 196-204; Taha, M., Ismail, N.H., Lalani, S., Fatmi, M.Q., Atia-tul-Wahab, Siddiqui, S., Khan, K.M., Choudhary, M.I., (2015) Eur. J. Med. Chem., 92, pp. 387-400; Taha, M., Ismail, N.H., Imran, S., Rokei, M.Q.B., Saad, S.M., Khan, K.M., (2015) Bioorg. Med. Chem, 23, pp. 4155-4162; Imran, S., Taha, M., Ismail, N.H., Kashif, S.M., Rahim, F., Jamil, W., Hariono, M., Wahab, H., (2015) Eur. J. Med. Chem., 105, pp. 156-170; Taha, M., Ismail, N.H., Imran, S., Selvaraj, M., Rahim, F., (2016) RSC Adv., 6, pp. 3003-3012; Taha, M., Sultan, S., Nuzar, H.A., Rahim, F., Imran, S., Ismail, N.H., Naz, H., Ullah, H., (2016) Bioorg. Med. Chem., 24, pp. 3696-3704; Salum, L.B., Mascarello, A., Canevarolo, R.R., Altei, W.F., Laranjeira, A.B.A., Neuenfeldt, P.D., Stumpf, T.R., Nunes, R.J., (2015) Eur. J. Med. Chem., 96, pp. 504-518; Sundaree, S., Vaddula, B.R., Tantak, M.P., Khandagale, S.B., Shi, C., Shah, K., Kumar, D., (2016) Med. Chem. Res., 25, pp. 941-950; Bayomi, S.M., Moustafa, M.A., Maarouf, A.R., Abutaleb, M.H., (2016) J. Am. Sci., 12, pp. 40-56; Nagamallu, R., Srinivasan, B., Ningappa, M.B., Kariyappa, A.K., (2016) Bioorg. Med. Chem. Lett, 26, pp. 690-694; Refat, H.M., Fadda, A.A., (2013) Eur. J. Med. Chem., 70, pp. 419-426; Ledour, G., Moroy, G., Rouffet, M., Bourguet, E., Guillaume, D., Decarme, M., Elmourabit, H., Sapi, J., (2008) Bioorg. Med. Chem., 16, pp. 8745-8759; Yang, L., Wang, P., Wu, J.-F., Yang, L.-M., Wang, R.-R., Pang, W., Li, Y.-A., Li, X., (2016) Bioorg. Med. Chem., 24, pp. 2125-2136; Galayev, O., Garazd, Y., Garazd, M., Lesyk, R., (2015) Eur. J. Med. Chem., 105, pp. 171-181; Bondock, S., Gieman, H., (2015) Res. Chem. Intermed., 41, pp. 8381-8403; Kouznetsov, V.V., M�ndez, L.Y.V., Acevedo, A.M., (2010) Lett. Drug Des. Discov., 7, pp. 710-715; Maguire, M.P., Sheets, K.R., McVety, K., Spada, A.P., Zillberstein, A., (1994) J. Med. Chem., 37, pp. 2129-2137; Vijay Avin, B.R., Thirusangu, P., Lakshmi Ranganatha, V., Firdouse, A., Prabhakar, B.T., Khanum, S.A., (2014) Eur. J. Med. Chem., 75, pp. 211-221; Mohamed, K.O., Nissan, Y.M., El-Malah, A.A., Ahmed, W.A., Ibrahim, D.M., Sakr, T.M., Motaleb, M.A., (2017) Eur. J. Med. Chem., 135, pp. 424-433; Abd-Elal, R.M., Shamma, R.N., Rashed, H.M., Bendas, E.R., (2016) Drug Deliv, 23, pp. 3374-3386; Meth-Cohn, O., Narine, B., Tarnowski, B., (1981) J. Chem. Soc. Perkin Trans, 1, pp. 1520-1530; Stener, A., (1960) Gazz. Chim. Ital., 90, pp. 1795-1799; Klosa, J., (1954) Arch. Pharm. (Weinheim), 287, pp. 302-304; Allam, Y.A., Nawwar, G.A.M., (2002) Heteroat. Chem., 13, pp. 207-210; Mahmoud, R.F., El-Ziaty, A.K., Abu El-Azm, F.S.M., Ismail, M.F., Shiba, S.A., (2013) J. Chem. Res., 37, pp. 80-85; Ried, W., Meyer, A., (1957) Chem. Ber., 90, pp. 2841-2848; Gharib, M.I., Burnett, A.K., (2002) Eur. J. Heart Fail., 4, pp. 235-242; Suffness, M., Pezzuto, J.M., Assays related to cancer drug discovery (1990) Methods in Plant Biochemistry: Assays for Bioactivity, 6, pp. 71-133. , K. Hostettmann Academic Press London, UK; Igney, F.H., Krammer, P.H., (2002) Nat. Rev. Canc., 2, pp. 277-288; Fulda, S., Debatin, K.M., (2006) Oncogene, 25, pp. 4798-4811; Youns, M., Efferth, T., Hoheisel, J.D., (2011) Eur. J. Pharmacol., 650, pp. 170-177; Youns, M., Efferth, T., Reichling, J., Fellenberg, K., Bauer, A., Hoheisel, J.D., (2009) Biochem. Pharmacol., 78, pp. 273-283; Youns, M., Fathy, G.M., (2013) J. Cell. Biochem., 114, pp. 2654-2665; Youns, M., Hoheisel, J.D., Efferth, T., (2010) Planta Med., 76, pp. 2019-2025; Heravi, R.E., Hadizadeh, F., Sankian, M., Afshari, J.T., Taghdisi, S.M., Jafarian, H., Behravan, J., (2011) Eur. J. Pharmaceut. Sci., 44, pp. 479-486; Wen, X.-Y., Wu, S.-Y., Li, Z.-Q., Liu, Z.-Q., Zhang, J.-J., Wang, G.-F., Jiang, Z.-H., Wu, S.-G., (2009) Phytother Res., 23, pp. 778-784; Thompson, J.S., Asmis, R., Glass, J., Liu, H., Wilson, C., Nelson, B., Brown, S.A., Stromberg, A.J., (2006) Biochem. Biophys. Res. Commun., 343, pp. 435-442; Takashima, N., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitui, A., Mori, Y., Mori, R., Fujii, Y., (2008) Dis. Esophagus, 21, pp. 230-235; Lee, S.A., Ho, C., Roy, R., Kosinski, C., Patil, M.A., Tward, A.D., Fridlyand, J., Chen, X., (2008) Hepatology, 47, pp. 1201-1210; Moran, B.W., Anderson, F.P., Devery, A., Cloonan, S., Butler, W.E., Varughese, S., Draper, S.M., Kenny, P.T.M., (2009) Bioorg. Med. Chem., 17, pp. 4510-4522; Do, M.T., Kim, H., Tran, T.T.P., Khanal, T., Choi, J.H., Chung, Y.C., Jeong, T.C., Jeong, H.G., (2014) Toxicol. Appl. Pharmacol., 280, pp. 138-148; Madonna, S., B�clin, C., Laras, Y., Moret, V., Marcowycz, A., Lamoral-Theys, D., Dubois, J., Kraus, J.-L., (2010) Eur. J. Med. Chem., 45, pp. 623-638; Ohyashiki, J.H., Kobayashi, C., Hamamura, R., Okabe, S., Tauchi, T., Ohyashiki, K., (2009) Canc. Sci., 100, pp. 970-977; Foerster, F., Chen, T., Altmann, K.-H., Vollmar, A.M., (2016) Bioorg. Med. Chem., 24, pp. 123-129; Ramachandran, C., Rodriguez, S., Ramachandran, R., Nair, P.K.R., Fonseca, H., Khatib, Z., Escalon, E., Melnick, S.J., (2005) Anticancer Res., 25, pp. 3293-3302; Karapetsas, A., Giannakakis, A., Dangaj, D., Lanitis, E., Poulos, S., Lambropoulou, M., Tanyi, J.L., Sandaltzopoulos, R., (2015) BioMed Res. Int., pp. 1-9. , ID 712438; Nair, S.V.G., Ziaullah, H.P., Rupasinghe, V., (2014) PLoS One, 9, pp. 1-16; Qiao, J., Kang, J., Cree, J., Evers, M., Chung, D.H., (2005) Ann. Surg., 241, pp. 684-692; Motaghed, M., Al-Hassan, F.M., Hamid, S.S., (2014) Int. J. Mol. Med., 33, pp. 8-16; Flaman, A.S., Gravel, C., Hashem, A.M., Tocchi, M., Li, X., (2011) Toxicol. Appl. Pharmacol., 253, pp. 130-136; Zouridakis, G., Biomedical Technology and Devices Handbook (2003), CRC Press; Rashed, H., Ibrahim, I., Motaleb, M., (2017) J. Radioanal. Nucl. Chem., pp. 1-11; Sanad, M.H., Sakr, T.M., Abdel-Haid, W.H.A., Marzook, E.A., (2017) J. Radioanal. Nucl. Chem., 314, pp. 1505-1515; Al-Wabli, R.I., Sakr, T.M., Khedr, M.A., Adli, A.S.A., Motaleb, M.A., Zaghary, W.A., (2016) Chem. Cent. J., 10, p. 73; Essa, B.M., Sakr, T.M., Khedr, M.A., El-Essawy, F.A., El Mohty, A.A., (2015) Eur. J. Pharmaceut. Sci., 76, pp. 102-109; Saha, G.B., Characteristics of Specific Radiopharmaceuticals (Chap. 7), Fundamentals of Nuclear Pharmacy (2010), sixth ed. Springer New York Heidelberg Dordrecht London; Sakr, T.M., Khedr, M.A., Rashed, H.M., Mohamed, M.E., (2018) Molecules, 23, p. 496; Swidan, M.M., Sakr, T.M., Motaleb, M.A., Abd El-Bary, A., El-Kolaly, M.T., (2015) J. Radioanal. Nucl. Chem., 303, pp. 531-539; Meth-Cohn, O., Narine, B., Tarnowski, B., (1981) J. Chem. Soc. Perkin Trans. I, pp. 1520-1530; Klosa, J., (1955) Arch. Pharmaz. Ber.dtsch. pharmaz. Ges, 288, pp. 452-455; Khidre, R.E., Abdel-Wahab, B.F., Badria, F.A., (2011) Lett. Drug Des. Discov., 8, pp. 640-648; Ried, W., Schleimer, B., (1958) Angew. Chem., 70, pp. 164-169. , Chem. Abstr., 1959, 53, 1314f; Bondock, S., Nasr, T., Zaghary, W., Chantrapromma, S., Ghabbour, H., Fun, H.-K., (2014) Mol. Cryst. Liq. Crsyt., 605, pp. 165-178; Nasr, T., Bondock, S., Eid, S., (2014) Eur. J. Med. Chem., 84, pp. 491-504; Cali, J.J., Ma, D., Sobol, M., Simpson, D.J., Frackman, S., Good, T.D., Daily, W.J., Liu, D., (2006) Expet Opin. Drug Metabol. Toxicol., 2, pp. 629-645; Habig, W.H., Pabst, M.J., Jakoby, W.B., (1974) J. Biol. Chem., 249, pp. 7130-7139; Geskovski, N., Kuzmanovska, S., Crcarevska, M.S., Calis, S., Dimchevska, S., Petrusevska, M., Zdravkovski, P., Goracinova, K., (2013) J. Labelled Comp. Radiopharm, 56, pp. 689-695; Rashed, H.M., Shamma, R.N., Basalious, E.B., (2017) Drug Deliv, 24, pp. 181-187; Rashed, H., Marzook, F., Farag, H., (2016) La radiologia medica, 121, pp. 935-943; Sakr, T.M., Ibrahim, A.B., Fasih, T.W., Rashed, H.M., (2017) J. Radioanal. Nucl. Chem., 314, pp. 2091-2098; Hina, S., Rajoka, M.I., Roohi, S., Haque, A., Qasim, M., (2014) Appl. Biochem. Biotechnol., 174, pp. 1420-1433; Hina, S., Roohi, S., Rajoka, M.I., Haque, A., Bokhari, T.H., Sohaib, M., (2015) J. Radioanal. Nucl. Chem., 304, pp. 553-561; Abouhussein, D.M.N., Khattab, A., Bayoumi, N.A., Mahmoud, A.F., Sakr, T.M., (2018) J. Drug Deliv. Sci. Technol., 43, pp. 129-140; Nour, S.A., Abdelmalak, N.S., Naguib, M.J., Rashed, H.M., Ibrahim, A.B., (2016) Drug Deliv, 23 (9), pp. 3681-3695; Sakr, T.M., Motaleb, M., Zaghary, W., (2015) J. Radioanal. Nucl. Chem., 303, pp. 399-406; Motaleb, M.A., El-Kolaly, M.T., Rashed, H.M., Abd El-Bary, A., (2011) J. Radioanal. Nucl. Chem., 289, pp. 915-921; Swidan, M.M., Sakr, T.M., Motaleb, M.A., Abd El-Bary, A., El-Kolaly, M.T., (2014) J. Labelled Comp. Radiopharm, 57, pp. 593-599
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