In vivo anti-inflammatory activity and UPLC-MS/MS profiling of the peels and pulps of Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEzzat, Shahira M
dc.contributor.authorRaslan M.
dc.contributor.authorSalama M.M.
dc.contributor.authorMenze E.T.
dc.contributor.authorEl Hawary S.S.
dc.contributor.otherDepartment of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.other6th October12566
dc.contributor.otherEgypt; Biotechnology and Life Sciences Department
dc.contributor.otherFaculty of Postgraduate Studies for Advanced Sciences
dc.contributor.otherBeni-Suef University62511
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherThe British University in Egypt
dc.contributor.otherEl-Sherouk City
dc.contributor.otherEgypt; Department of Pharmacology and Toxicology
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.other11566
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:37Z
dc.date.available2020-01-09T20:40:37Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractEthnopharmacological relevance: Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus are the most famous varieties of netted muskmelon or cantaloupe in Egypt. Cantaloupe has a great reputation as an anti-inflammatory drug for hot inflammation of liver, cough, eczema, and kidney disorders such as ulcers in the urinary tract, and our objective was to confirm this use scientifically. Materials and methods: Inflammation was induced in adult male Sprague Dawley rats by subcutaneous injection of 0.05 ml of carrageenan (1% solution in saline) into the plantar surface of the right hind paw 30 min after oral pretreatment of the rats with 95% ethanolic extracts of Cucumis melo var. cantalupensis peels (CCP) and pulps (CCU) and Cucumis melo var. reticulatus peels (CRP) and pulps (CRU) at doses of 25 and 50 mg/kg. Indomethacin (10 mg/kg) was used as a standard drug. The effect of the tested samples was measured on the oedema volume, as well as PGE-2, TNF-? IL-6 and IL-1? levels. Metabolic profiling of the extracts was performed using UPLC-MS/MS analysis. Results: Pretreatment of rats with the ethanol extract of the pulps and peels of the two varieties at doses of 25 and 50 mg/kg significantly inhibited the carrageenan-induced increase in the oedema volume of the rat paws after 3 h, except for the low dose of the French cantaloupe pulp. CRP at 50 mg/kg caused the most significant reductions in both TNF-? (P < 0.05) and IL-1? (P < 0.001) levels, while CCP caused the most significant reductions in PGE-2 and IL-6 (P < 0.05) levels. Increases in PGE-2, TNF-? IL-6 and IL-1? levels were also significantly prevented by indomethacin (10 mg/kg). UPLC-MS/MS facilitated the identification of 44 phenolic compounds, including phenolic acids and flavonoids. Conclusion: This is the first report of the chemical and biological study of the peels of Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus. � 2019en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23015&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.jep.2019.03.015
dc.identifier.doiPubMed ID 30857984
dc.identifier.issn3788741
dc.identifier.otherhttps://doi.org/10.1016/j.jep.2019.03.015
dc.identifier.otherPubMed ID 30857984
dc.identifier.urihttps://t.ly/py76r
dc.language.isoEnglishen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofseriesJournal of Ethnopharmacology
dc.relation.ispartofseries237
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectCantaloupeen_US
dc.subjectInterleukin-6en_US
dc.subjectPeelen_US
dc.subjectTumour necrosis factor-?en_US
dc.subjectUPLC-MS/MSen_US
dc.subjectantiinflammatory agenten_US
dc.subjectCucumis melo var cantalupensis extracten_US
dc.subjectCucumis melo var reticulatus extracten_US
dc.subjectflavonoiden_US
dc.subjectindometacinen_US
dc.subjectinterleukin 1betaen_US
dc.subjectinterleukin 6en_US
dc.subjectphenol derivativeen_US
dc.subjectplant extracten_US
dc.subjectprostaglandin E2en_US
dc.subjecttumor necrosis factoren_US
dc.subjectunclassified drugen_US
dc.subjectantiinflammatory agenten_US
dc.subjectcarrageenanen_US
dc.subjectIl6 protein, raten_US
dc.subjectinterleukin 1betaen_US
dc.subjectinterleukin 6en_US
dc.subjectphytochemicalen_US
dc.subjectplant extracten_US
dc.subjectprostaglandin E2en_US
dc.subjecttumor necrosis factoren_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectantiinflammatory activityen_US
dc.subjectArticleen_US
dc.subjectcantaloupeen_US
dc.subjectcarrageenan-induced paw edemaen_US
dc.subjectcontrolled studyen_US
dc.subjectCucumisen_US
dc.subjectCucumis melo var reticulatusen_US
dc.subjectdose responseen_US
dc.subjectfruit peelen_US
dc.subjectfruit pulpen_US
dc.subjectin vivo studyen_US
dc.subjectinflammationen_US
dc.subjectliquid chromatography-mass spectrometryen_US
dc.subjectmaleen_US
dc.subjectmetabolismen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectanimalen_US
dc.subjectchemically induceden_US
dc.subjectchemistryen_US
dc.subjectedemaen_US
dc.subjectfooten_US
dc.subjectfruiten_US
dc.subjectliquid chromatographyen_US
dc.subjectmuskmelonen_US
dc.subjectpathologyen_US
dc.subjectphytotherapyen_US
dc.subjectSprague Dawley raten_US
dc.subjecttandem mass spectrometryen_US
dc.subjectAnimalsen_US
dc.subjectAnti-Inflammatory Agentsen_US
dc.subjectCarrageenanen_US
dc.subjectChromatography, Liquiden_US
dc.subjectCucumis meloen_US
dc.subjectDinoprostoneen_US
dc.subjectEdemaen_US
dc.subjectFooten_US
dc.subjectFruiten_US
dc.subjectInterleukin-1betaen_US
dc.subjectInterleukin-6en_US
dc.subjectMaleen_US
dc.subjectPhytochemicalsen_US
dc.subjectPhytotherapyen_US
dc.subjectPlant Extractsen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectTandem Mass Spectrometryen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.titleIn vivo anti-inflammatory activity and UPLC-MS/MS profiling of the peels and pulps of Cucumis melo var. cantalupensis and Cucumis melo var. reticulatusen_US
dc.typeArticleen_US
dcterms.isReferencedByAgarwal, H., Nakara, A., Shanmugam, V.K., Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: a review (2019) Biomed. Pharmacother., 109, pp. 2561-2572; Amaro, M., Rocha, J., Vila-Real, H., Eduardo-Figueira, M., Mota-Filipe, H., Sepodes, B., Ribeiro, M.H., Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice (2009) Food Res. Int., 42, pp. 1010-1017; Artis, D., Spits, H., The biology of innate lymphoid cells (2015) Nature, 517, pp. 293-301; Bai, S.K., Lee, S.J., Na, H.J., Ha, K.S., Han, J.A., Lee, H., Kwon, Y.G., Kim, Y.M., ?-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-?B activation (2005) Exp. Mol. Med., 37, pp. 323-334; Carballo-Villalobos, A.I., Gonz�lez-Trujano, M.E., L�pez-Mu�oz, F.J., Evidence of mechanism of action of anti-inflammatory/antinociceptive activities of acacetin (2014) Eur. J. Pain, 18, pp. 396-405; Chang, W.T., Huang, W.C., Liou, C.J., Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages (2012) Food Chem., 134, pp. 972-979; Cheng, X.L., Wan, J.Y., Li, P., Qi, L.W., Ultrasonic/microwave assisted extraction and diagnostic ion filtering strategy by liquid chromatography�quadrupole time-of-flight mass spectrometry for rapid characterization of flavonoids in Spatholobus suberectus (2011) J. Chromatogr. A, 1218, pp. 5774-5786; Figueirinha, A., Paranhos, A., P�rez-Alonso, J., Santos-Buelga, C., Batista, M., Cymbopogon citratus leaves characterization of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols (2008) Food Chem., 110, pp. 718-728; Fleshman, M.K., Lester, G.E., Riedl, K.M., Kopec, R.E., Narayanasamy, S., Curley, R.W., Jr., Schwartz, S.J., Harrison, E.H., Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons: determinations of ?-carotene bioaccessibility and bioavailability (2011) J. Agric. Food Chem., 59, pp. 4448-4454; Gampe, N., Darcsi, A., Lohner, S., B�ni, S., Kursinszki, L., Characterization and identification of isoflavonoid glycosides in the root of Spiny restharrow (Ononis spinosa L.) by HPLC-QTOF-MS, HPLC�MS/MS and NMR (2016) J. Pharm. Biomed. Anal., 123, pp. 74-81; Goetzl, E.J., An, S., Smith, W.L., Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases (1995) FASEB J., 9, pp. 1051-1058; Hofmann, T., Nebehaj, E., Albert, L., Antioxidant properties and detailed polyphenol profiling of European hornbeam (Carpinus betulus L.) leaves by multiple antioxidant capacity assays and high-performance liquid chromatography/multistage electrospray mass spectrometry (2016) Ind. Crops Prod., 87, pp. 340-349; Hossain, M.B., Rai, D.K., Brunton, N.P., Martin-Diana, A.B., Barry-Ryan, C., Characterization of phenolic composition in Lamiaceae spices by LC-ESI-MS/MS (2010) J. Agric. Food Chem., 58, pp. 10576-10581; Ibrahim, R.M., El-Halawany, A.M., Saleh, D.O., El Naggar, E.B., El-Shabrawy, A.O., El-Hawary, S.S., HPLC-DAD-MS/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities (2015) Rev Bras Farmacogn, 25, pp. 134-141; Ibrahim, S.R.M., Mohamed, G.A., Cucumin S, a new phenylethyl chromone from Cucumis melo var. reticulatus seeds (2015) Rev Bras Farmacogn, 25, pp. 462-464; Ismail, H.I., Chan, K.W., Mariod, A.A., Ismail, M., Phenolic content and antioxidant activity of cantaloupe (Cucumis melo) methanolic extracts (2010) Food Chem., 119, pp. 643-647; Karar, M.G.E., Kuhnert, N., UPLC-ESI-Q-TOF-MS/MS characterization of phenolics from Crataegus monogyna and Crataegus laevigata (hawthorn) leaves, fruits and their herbal derived drops (crataegutt tropfen) (2015) J Chem Biol Ther, 1, pp. 1-23; Lee, E.J., Shin, S.Y., Kim, J.K., Woo, E.R., Kim, Y.M., Anti-inflammatory effects of amentoflavone on modulation of signal pathways in LPS-stimulated RAW264.7 cells (2012) Bull. Korean Chem. Soc., 33, pp. 2878-2881; Lee, J.K., Anti-inflammatory effects of eriodictyol in lipopolysaccharide-stimulated raw 264.7 murine macrophages (2011) Arch Pharm. Res. (Seoul), 34, pp. 671-679; Lin, L.Z., Harnly, J.M., Identification of the phenolic components of collard greens, kale, and Chinese broccoli (2009) J. Agric. Food Chem., 57, pp. 7401-7408; Lim, T.K., Cucumis melo (reticulatus group) (2012) Edible Medicinal and Non-medicinal Plants, pp. 222-230. , Springer Dordrecht; Ma, C., Dastmalchi, K., Flores, G., Wu, S.B., Pedraza-Penalosa, P., Long, C., Kennelly, E.J., Antioxidant and metabolite profiling of north American and neotropical blueberries using LC-TOF-MS and multivariate analyses (2013) J. Agric. Food Chem., 61, pp. 3548-3559; Montgomery, S.L., Bowers, W.J., Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system (2012) J. Neuroimmune Pharmacol., 7, pp. 42-59; Mueller, M., Hobiger, S., Jungbauer, A., Anti-inflammatory activity of extracts from fruits, herbs and spices (2010) Food Chem., 122, pp. 987-996; Nile, S.H., Ko, E.Y., Kim, D.H., Keum, Y.S., Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cycloox-ygenase-2 with anti-inflammatory activity (2016) Rev. bras. Farmacogn., 26, pp. 50-55; Parmar, H.S., Kar, A., Protective role of Mangifera indica, Cucumis melo and Citrullus vulgaris peel extracts in chemically induced hypothyroidism (2009) Chem. Biol. Interact., 177, pp. 254-258; Pedraza-Alva, G., P�rez-Mart�nez, L., Valdez-Hern�ndez, L., Meza-Sosa, K.F., Ando-Kuri, M. Negative regulation of the inflammasome: keeping inflammation under control (2015) Immunol. Rev., 265, pp. 231-257; Pinho-Ribeiro, F.A., Zarpelon, A.C., Mizokami, S.S., Borghi, S.M., Bordignon, J., Silva, R.L., Cunha, T.M., Verri, W.A., Jr., The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-?B activation (2016) J. Nutr. Biochem., 33, pp. 8-14; Preeti, Raju, P.N., Comprehensive overview of Cucumis melo (2017) Pharmaceut. Innovat. J, 6, pp. 181-186; Ramirez, J.E., Zambrano, R., Sep�lveda, B., Simirgiotis, M.J., Antioxidant properties and hyphenated HPLC-PDA-MS profiling of Chilean Pica mango fruits (Mangifera indica L. Cv. Pique�o) (2014) Molecules, 19, pp. 438-458; Rider, P., Carmi, Y., Voronov, E., Apte, R.N., Interleukin-1? (2013) Seminars in Immunology, 25, pp. 430-438. , Academic Press; Ritschel, P.S., de Lima Lins, T.C., Tristan, R.L., Buso, G.S.C., Buso, J.A., Ferreira, M.E., Development of microsatellite markers from an enriched genomic library for genetic analysis of melon (Cucumis melo L.) (2004) BMC Plant Biol., 4, p. 9; Salama, M., El-Hawary, S., Mousa, O., El-Askary, N., Esmat, A., In vivo TNF and IL-1? inhibitory activity of Phenolics isolated from Trachelospermum jasminoides Linl. (Lem) (2015) J. Med. Plants Res., 9, pp. 30-41; Sekhon-Loodu, S., Rupasinghe, H.V., Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages (2015) Int. Immunopharmacol., 25, pp. 199-206; Silva, C.F.M., Pinto, D.C.G.A., Silva, A.M.S., Chromones: a promising ring system for new anti- inflammatory drugs (2016) ChemMedChem, 11, pp. 2252-2260; Simirgiotis, M.J., Schmeda-Hirschmann, G., B�rquez, J., Kennelly, E.J., The Passiflora tripartita (banana passion) fruit: a source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC�DAD�ESI/MS/MS (2013) Molecules, 18, pp. 1672-1692; Sun, X., Zhang, Y., Chen, S., Fu, Y., Characterization and identification of the chemical constituents in the root of Lindera reflexa Hemsl. using ultra-high performance liquid chromatography coupled with linear trap quadrupole orbitrap mass spectrometry (2016) J. Pharm. Biomed. Anal., 126, pp. 34-47; Sun, Z., Zhao, L., Zuo, L., Qi, C., Zhao, P., Hou, X., A UHPLC�MS/MS method for simultaneous determination of six flavonoids, gallic acid and 5,8-dihydroxy-1,4-naphthoquinone in rat plasma and its application to a pharmacokinetic study of Cortex Juglandis Mandshuricae extract (2014) J. Chromatogr. B, 958, pp. 55-62; Vignali, D.A.A., Kuchroo, V.K., IL-12 family cytokines: immunological playmakers (2012) Nat. Immunol., 13 (8), pp. 722-728; Vouldoukis, I., Lacan, D., Kamate, C., Coste, P., Calenda, A., Mazier, D., Conti, M., Dugas, B., Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity (2004) J. Ethnopharmacol., 94 (1), pp. 67-75; Yang, S.L., Walters, T.W., Ethnobotany and the economic role of the Cucurbitaceae of China (1992) Econ. Bot., 46 (4), pp. 349-367; Yasir, M., Sultana, B., Nigam, P.S., Owusu-Apenten, R., Antioxidant and genoprotective activity of selected cucurbitaceae seed extracts and LC�ESIMS/MS identification of phenolic components (2016) Food Chem., 199, pp. 307-313; Zhang, M., Duan, C., Zang, Y., Huang, Z., Liu, G., The flavonoid composition of flavedo and juice from the pummelo cultivar (Citrus grandis (L.) Osbeck) and the grapefruit cultivar (Citrus paradisi) from China (2011) Food Chem., 129, pp. 1530-1536; Zhuang, B., Bi, Z.M., Wang, Z.Y., Duan, L., Lai, C.J.S., Liu, E.H., Chemical profiling and quantitation of bioactive compounds in Platycladi Cacumen by UPLC-Q-TOF-MS/MS and UPLC-DAD (2018) J. Pharm. Biomed. Anal., pp. 207-215
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