Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99m radionuclide: a potential molecular imaging probe for tumor diagnosis

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSwidan M.M.
dc.contributor.authorKhowessah O.M.
dc.contributor.authorEl-Motaleb M.A.
dc.contributor.authorEl-Bary A.A.
dc.contributor.authorEl-Kolaly M.T.
dc.contributor.authorSakr T.M.
dc.contributor.otherLabeled Compounds Department
dc.contributor.otherHot Labs Center
dc.contributor.otherEgyptian Atomic Energy Authority
dc.contributor.otherPO13759
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmaceutics and Industrial Pharmacy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherPO11562
dc.contributor.otherCairo
dc.contributor.otherEgypt; Radioactive Isotopes and Generator Department
dc.contributor.otherHot Labs Center
dc.contributor.otherEgyptian Atomic Energy Authority
dc.contributor.otherPO13759
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Sciences and Arts University
dc.contributor.other6th October City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:37Z
dc.date.available2020-01-09T20:40:37Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractBackground: The evolution of nanoparticles has gained prominence as platforms for developing diagnostic and/or therapeutic radiotracers. This study aims to develop a novel technique for fabricating a tumor diagnostic probe based on iron oxide nanoparticles excluding the utilization of chelating ligands. Methods: Tc-99m radionuclide was loaded into magnetic iron oxide nanoparticles platform (MIONPs) by sonication. 99mTc-encapsulated MIONPs were fully characterized concerning particles size, charge, radiochemical purity, encapsulation efficiency, in-vitro stability and cytotoxicity. These merits were biologically evaluated in normal and solid tumor bearing mice via different delivery approaches. Results: 99mTc-encapsulated MIONPs probe was synthesized with average particle size 24.08 7.9nm, hydrodynamic size 52nm, zeta potential -28mV, radiolabeling yield 96 0.83%, high in-vitro physiological stability, and appropriate cytotoxicity behavior. The in-vivo evaluation in solid tumor bearing mice revealed that the maximum tumor radioactivity accumulation (25.39 0.57, 36.40 0.59 and 72.61 0.82%ID/g) was accomplished at 60, 60 and 30min p.i. for intravenous, intravenous with physical magnet targeting and intratumoral delivery, respectively. The optimum T/NT ratios of 57.70, 65.00 and 87.48 were demonstrated at 60min post I.V., I.V. with physical magnet targeting and I.T. delivery, respectively. These chemical and biological characteristics of our prepared nano-probe demonstrate highly advanced merits over the previously reported chelator mediated radiolabeled nano-formulations which reported maximum tumor uptakes in the scope of 3.65 0.19 to 16.21 2.56%ID/g. Conclusion: Stabilized encapsulation of 99mTc radionuclide into MIONPs elucidates a novel strategy for developing an advanced nano-sized radiopharmaceutical for tumor diagnosis. [Figure not available: see fulltext.]. 2019, Springer Nature Switzerland AG.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=20710&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s40199-019-00241-y
dc.identifier.doiPubMed ID 30706223
dc.identifier.issn15608115
dc.identifier.otherhttps://doi.org/10.1007/s40199-019-00241-y
dc.identifier.otherPubMed ID 30706223
dc.identifier.urihttps://t.ly/py7mO
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesDARU, Journal of Pharmaceutical Sciences
dc.relation.ispartofseries27
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectChelator free radiolabelingen_US
dc.subjectEncapsulationen_US
dc.subjectMagnetic iron oxide nanoparticlesen_US
dc.subjectTc-99m radionuclideen_US
dc.subjectTumor deliveryen_US
dc.subjectTumor diagnosisen_US
dc.subjectmagnetic iron oxide nanoparticleen_US
dc.subjectmagnetic nanoparticleen_US
dc.subjecttechnetium 99men_US
dc.subjectultrasmall superparamagnetic iron oxideen_US
dc.subjectunclassified drugen_US
dc.subjectferric ionen_US
dc.subjectferric oxideen_US
dc.subjectmagnetite nanoparticleen_US
dc.subjecttechnetiumen_US
dc.subjectTechnetium-99en_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectcell viabilityen_US
dc.subjectchemical parametersen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug cytotoxicityen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug stabilityen_US
dc.subjectencapsulation efficiencyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthydrodynamic sizeen_US
dc.subjectin vitro studyen_US
dc.subjectin vivo studyen_US
dc.subjectisotope labelingen_US
dc.subjectmolecular imagingen_US
dc.subjectmouseen_US
dc.subjectnanoencapsulationen_US
dc.subjectnonhumanen_US
dc.subjectparticle chargeen_US
dc.subjectparticle sizeen_US
dc.subjectphysical parametersen_US
dc.subjectradiochemical purityen_US
dc.subjectsynthesisen_US
dc.subjecttumor diagnosisen_US
dc.subjectultrasounden_US
dc.subjectzeta potentialen_US
dc.subjectanimalen_US
dc.subjectcancer transplantationen_US
dc.subjectcell lineen_US
dc.subjectcell survivalen_US
dc.subjectchemistryen_US
dc.subjectdiagnostic imagingen_US
dc.subjectintravenous drug administrationen_US
dc.subjectAdministration, Intravenousen_US
dc.subjectAnimalsen_US
dc.subjectCell Lineen_US
dc.subjectCell Survivalen_US
dc.subjectFerric Compoundsen_US
dc.subjectHumansen_US
dc.subjectMagnetite Nanoparticlesen_US
dc.subjectMiceen_US
dc.subjectNeoplasm Transplantationen_US
dc.subjectParticle Sizeen_US
dc.subjectTechnetiumen_US
dc.titleIron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99m radionuclide: a potential molecular imaging probe for tumor diagnosisen_US
dc.typeArticleen_US
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