The relevance of single-nucleotide polymorphism +62 g>a to the expression of resistin gene affecting serum resistin levels in metabolic syndrome in the egyptian population

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2020

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Article

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Bentham Science Publishers

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Current Pharmaceutical Biotechnology;Volume 21, Issue 7, 2020, Pages 626-634

Abstract

Background: Metabolic syndrome (MS) is a clinical condition consisting of risk factors associated with type two diabetes and developing cardiovascular disease. It has been suggested that resistin is a linkage between obesity, inflammation and type two diabetes. This study aims to investigate whether Resistin Gene (RETN) polymorphism (+62G>A) is linked to MS and resistin levels among the Egyptian population. Methods: This study was performed with 310 Egyptian volunteers: 160 MS subjects and 150 controls. Anthropometric parameters and biochemical variables were determined. The RETN +62G>A polymorphism was genotyped by PCR-RFLP technique. Results: The resistin levels of the MS group were significantly higher than those of the control group. Resistin levels were positively correlated with anthropometric parameters and liver biomarkers in the MS group. According to RETN +62G>A polymorphism, carriers with the A allele (GA/AA) had significantly increased resistin levels than subjects with the GG genotype, consequently, the RETN +62G >A polymorphism was found to be related to MS, biochemical parameters and anthropometric variables. Conclusion: These findings propose that the RETN +62G>A polymorphism has a great impact on the circulating resistin concentrations, and that resistin levels are strongly related to MS. Therefore, this RETN polymorphism is related to the risk of the prevalence of MS in the Egyptians

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Scopus

Keywords

Egyptian population, Gene polymorphisms, Metabolic syndrome, Obesity, Resistin, RETN +62G>A

Citation

Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., (...), Groop, L. Cardiovascular morbidity and mortality associated with the metabolic syndrome (Open Access) (2001) Diabetes Care, 24 (4), pp. 683-689. Cited 3547 times. http://care.diabetesjournals.org/ doi: 10.2337/diacare.24.4.683 View at Publisher 2 Ford, E.S., Giles, W.H., Dietz, W.H. Prevalence of the metabolic syndrome among US adults: Findings from the Third National Health and Nutrition Examination Survey (Open Access) (2002) Journal of the American Medical Association, 287 (3), pp. 356-359. Cited 5397 times. http://jama.jamanetwork.com/journal.aspx doi: 10.1001/jama.287.3.356 View at Publisher 3 Grundy, S.M., Brewer Jr., H.B., Cleeman, J.I., Smith Jr., S.C., Lenfant, C. Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition (Open Access) (2004) Circulation, 109 (3), pp. 433-438. Cited 3420 times. doi: 10.1161/01.CIR.0000111245.75752.C6 View at Publisher 4 Montague, C.T., O'Rahilly, S. The perils of portliness: Causes and consequences of visceral adiposity (Open Access) (2000) Diabetes, 49 (6), pp. 883-888. Cited 552 times. http://diabetes.diabetesjournals.org/ doi: 10.2337/diabetes.49.6.883 View at Publisher 5 Matsuzawa, Y., Funahashi, T., Nakamura, T. Molecular mechanism of Metabolic Syndrome X: Contribution of adipocytokines·adipocyte-derived bioactive substances (1999) Annals of the New York Academy of Sciences, 892, pp. 146-154. Cited 506 times. http://www.blackwellpublishing.com/0077-8923 doi: 10.1111/j.1749-6632.1999.tb07793.x View at Publisher 6 Spiegelman, B.M., Flier, J.S. Obesity and the regulation of energy balance (Open Access) (2001) Cell, 104 (4), pp. 531-543. Cited 1694 times. www.cell.com doi: 10.1016/S0092-8674(01)00240-9 View at Publisher 7 Kahn, B.B., Flier, J.S. Obesity and insulin resistance (Open Access) (2000) Journal of Clinical Investigation, 106 (4), pp. 473-481. Cited 2098 times. http://www.jci.org doi: 10.1172/JCI10842 View at Publisher 8 Friedman, J.M. Obesity in the new millennium (2000) Nature, 404 (6778), pp. 632-634. Cited 596 times. http://www.nature.com/nature/index.html doi: 10.1038/35007504 View at Publisher 9 Saltiel, A.R., Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism (2001) Nature, 414 (6865), pp. 799-806. Cited 3361 times. doi: 10.1038/414799a View at Publisher 10 Uysal, K.T., Wiesbrock, S.M., Marino, M.W., Hotamisligil, G.S. Protection from obesity-induced insulin resistance in mice lacking TNF- α function (1997) Nature, 389 (6651), pp. 610-614. Cited 1725 times. doi: 10.1038/39335 View at Publisher 11 Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., (...), Lazar, M.A. The hormone resistin links obesity to diabetes (2001) Nature, 409 (6818), pp. 307-312. Cited 3604 times. doi: 10.1038/35053000 View at Publisher 12 Banerjee, R.R., Rangwala, S.M., Shapiro, J.S., Rich, A.S., Rhoades, B., Qi, Y., Wang, J., (...), Lazar, M.A. Regulation of Fasted Blood Glucose by Resistin (2004) Science, 303 (5661), pp. 1195-1198. Cited 589 times. doi: 10.1126/science.1092341 View at Publisher 13 Bouchard, L., Weisnagel, S.J., Engert, J.C., Hudson, T.J., Bouchard, C., Vohl, M.-C., Pérusse, L. Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Québec Family Study (2004) Journal of Endocrinological Investigation, 27 (11), pp. 1003-1009. Cited 47 times. http://link.springer.com/journal/40618 doi: 10.1007/BF03345301 View at Publisher 14 Pizzuti, A., Argiolas, A., Paola, R.D., Baratta, R., Rauseo, A., Bozzali, M., Vigneri, R., (...), Frittitta, L. Comment: An ATG repeat in the 3′-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance (Open Access) (2002) Journal of Clinical Endocrinology and Metabolism, 87 (9), pp. 4403-4406. Cited 75 times. doi: 10.1210/jc.2002-020096 View at Publisher 15 Kumar, S., Gupta, V., Srivastava, N., Gupta, V., Mishra, S., Mishra, S., Natu Shankar, M., (...), Negi, M.P.S. Resistin 420C/G gene polymorphism on circulating resistin, metabolic risk factors and insulin resistance in adult women (2014) Immunology Letters, Part PB 162 (2), pp. 287-291. Cited 17 times. www.elsevier.com/locate/immlet doi: 10.1016/j.imlet.2014.07.009 View at Publisher 16 Engert, J.C., Vohl, M.-C., Williams, S.M., Lepage, P., Loredo-Osti, J.C., Faith, J., Doré, C., (...), Hudson, T.J. 5′ flanking variants of resistin are associated with obesity (Open Access) (2002) Diabetes, 51 (5), pp. 1629-1634. Cited 147 times. http://diabetes.diabetesjournals.org/ doi: 10.2337/diabetes.51.5.1629 View at Publisher 17 McTernan, C.L., McTernan, P.G., Harte, A.L., Levick, P.L., Barnett, A.H., Kumar, S. Resistin, central obesity, and type 2 diabetes (2002) Lancet, 359 (9300), pp. 46-47. Cited 317 times. doi: 10.1016/S0140-6736(02)07281-1 View at Publisher 18 Kunnari, A., Ukkola, O., Kesäniemi, Y.A. Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients (2005) Diabetic Medicine, 22 (5), pp. 583-589. Cited 60 times. doi: 10.1111/j.1464-5491.2005.01480.x View at Publisher 19 Reilly, M.P., Lehrke, M., Wolfe, M.L., Rohatgi, A., Lazar, M.A., Rader, D.J. Resistin is an inflammatory marker of atherosclerosis in humans (Open Access) (2005) Circulation, 111 (7), pp. 932-939. Cited 713 times. doi: 10.1161/01.CIR.0000155620.10387.43 View at Publisher 20 Muse, E.D., Feldman, D.I., Blaha, M.J., Dardari, Z.A., Blumenthal, R.S., Budoff, M.J., Nasir, K., (...), Allison, M.A. The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis (2015) Atherosclerosis, 239 (1), pp. 101-108. Cited 49 times. www.elsevier.com/locate/atherosclerosis doi: 10.1016/j.atherosclerosis.2014.12.044 View at Publisher 21 Maggio, A.B.R., Wacker, J., Montecucco, F., Galan, K., Pelli, G., MacH, F., Beghetti, M., (...), Farpour-Lambert, N.J. Serum resistin and inflammatory and endothelial activation markers in obese adolescents (2012) Journal of Pediatrics, 161 (6), pp. 1022-1027.e1. Cited 25 times. http://www.elsevier.com/inca/publications/store/6/2/3/3/1/1/index.htt doi: 10.1016/j.jpeds.2012.05.063 View at Publisher 22 Gherlan, I., Vladoiu, S., Alexiu, F., Giurcaneanu, M., Oros, S., Brehar, A., Procopiuc, C., (...), Dumitrache, C. Adipocytokine profile and insulin resistance in childhood obesity (2012) Maedica (Buchar.), 7 (3), pp. 205-213. Cited 21 times. 23400230 23 Owecki, M., Nikisch, E., Miczke, A., Pupek-Musialik, D., Sowiński, J. Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans (2010) Neuroendocrinology Letters, 31 (5), pp. 673-678. Cited 20 times. 24 Uslu, S., Kebapçi, N., Kara, M., Bal, C. Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus (Open Access) (2012) Experimental and Therapeutic Medicine, 4 (1), pp. 113-120. Cited 46 times. http://www.spandidos-publications.com/serveFile/etm_4_1_113_PDF.pdf?type=article&article_id=etm_4_1_113&item=PDF doi: 10.3892/etm.2012.557 View at Publisher 25 Conneely, K.N., Silander, K., Scott, L.J., Mohlke, K.L., Lazaridis, K.N., Valle, T.T., Tuomilehto, J., (...), Boehnke, M. Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects (Open Access) (2004) Diabetologia, 47 (10), pp. 1782-1788. Cited 75 times. doi: 10.1007/s00125-004-1537-x View at Publisher 26 Friedman, J.M., Halaas, J.L. Leptin and the regulation of body weight in mammals (1998) Nature, 395 (6704), pp. 763-770. Cited 4151 times. http://www.nature.com/nature/index.html doi: 10.1038/27376 View at Publisher 27 Farooqi, I.S., Keogh, J.M., Kamath, S., Jones, S., Gibson, W.T., Trussell, R., Jebb, S.A., (...), O'rahilly, S. Metabolism: Partial leptin deficiency and human adiposity (2001) Nature, 414 (6859), pp. 34-35. Cited 300 times. doi: 10.1038/35102112 View at Publisher 28 Alberti, K.G.M.M., Zimmet, P., Shaw, J. The metabolic syndrome - A new worldwide definition (2005) Lancet, 366 (9491), pp. 1059-1062. Cited 4911 times. doi: 10.1016/S0140-6736(05)67402-8 View at Publisher 29 Zimmet, P., Magliano, D., Matsuzawa, Y., Alberti, G., Shaw, J. The metabolic syndrome: a global public health problem and a new definition. (Open Access) (2005) Journal of atherosclerosis and thrombosis, 12 (6), pp. 295-300. Cited 511 times. doi: 10.5551/jat.12.295 View at Publisher 30 (1995) Physical Status: The Use of and Interpretation of Anthropometry Report of a WHO Expert Committee. Cited 5539 times. 31 Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo Jr., J.L., Jones, D.W., (...), Roccella, E.J. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report (2003) Journal of the American Medical Association, 289 (19), pp. 2560-2572. Cited 14158 times. doi: 10.1001/jama.289.19.2560 View at Publisher 32 Gerber, M., Boettner, A., Seidel, B., Lammert, A., Bär, J., Schuster, E., Thiery, J., (...), Kratzsch, J. Serum resistin levels of obese and lean children and adolescents: Biochemical analysis and clinical relevance (Open Access) (2005) Journal of Clinical Endocrinology and Metabolism, 90 (8), pp. 4503-4509. Cited 151 times. http://jcem.endojournals.org/cgi/reprint/90/8/4503 doi: 10.1210/jc.2005-0437 View at Publisher 33 Friedewald, W.T., Levy, R.I., Fredrickson, D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. (1972) Clinical Chemistry, 18 (6), pp. 499-502. Cited 22941 times. View at Publisher 34 Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man (Open Access) (1985) Diabetologia, 28 (7), pp. 412-419. Cited 21715 times. doi: 10.1007/BF00280883 View at Publisher 35 Cao, H., Hegele, R.A. Single nucleotide polymorphisms of the resistin (RSTN) gene (Open Access) (2001) Journal of Human Genetics, 46 (9), pp. 553-555. Cited 31 times. doi: 10.1007/s100380170040 View at Publisher 36 Cho, Y.M., Youn, B.-S., Chung, S.S., Kim, K.W., Lee, H.K., Yu, K.-Y., Park, H.J., (...), Park, K.S. Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans (Open Access) (2004) Diabetologia, 47 (3), pp. 559-565. Cited 114 times. link.springer.de/link/service/journals/00125/index.htm doi: 10.1007/s00125-003-1319-x View at Publisher 37 Di Paola, R., Frittitta, L., Miscio, G., Bozzali, M., Baratta, R., Centra, M., Spampinato, D., (...), Trischitta, V. A variation in 3’ utr of hptp1b increases specific gene expression and associates with insulin resistance (Open Access) (2002) American Journal of Human Genetics, 70 (3), pp. 806-812. Cited 156 times. doi: 10.1086/339270 View at Publisher 38 Principe, A., Melgar-Lesmes, P., Fernández-Varo, G., del Arbol, L.R., Ros, J., Morales-Ruiz, M., Bernardi, M., (...), Jiménez, W. The hepatic apelin system: A new therapeutic target for liver disease (2008) Hepatology, 48 (4), pp. 1193-1201. Cited 81 times. http://www3.interscience.wiley.com/cgi-bin/fulltext/121413709/PDFSTART doi: 10.1002/hep.22467 View at Publisher 39 Lau, C.-H., Muniandy, S. Influence of adiponectin and resistin gene polymorphisms on quantitative traits related to metabolic syndrome among Malay, Chinese, and Indian Men in Malaysia (2013) Biochemical Genetics, 51 (1-2), pp. 166-174. Cited 5 times. doi: 10.1007/s10528-012-9552-y View at Publisher 40 Osawa, H., Yamada, K., Onuma, H., Murakami, A., Ochi, M., Kawata, H., Nishimiya, T., (...), Makino, H. The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3 (Open Access) (2004) American Journal of Human Genetics, 75 (4), pp. 678-686. Cited 182 times. http://www.elsevier.com/wps/find/journaldescription.cws_home/713561/description#description doi: 10.1086/424761 View at Publisher 41 Hishida, A., Wakai, K., Okada, R., Morita, E., Hamajima, N., Hosono, S., Higaki, Y., (...), Naito, M. Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study (Open Access) (2013) Endocrine Journal, 60 (2), pp. 237-243. Cited 7 times. https://www.jstage.jst.go.jp/article/endocrj/60/2/60_EJ12-0307/_pdf doi: 10.1507/endocrj.EJ12-0307 View at Publisher 42 Mojtaba, E., Davood, K., Mohammadali, S., Hussein, D. Estimation of the correlation of serum resistin with metabolic syndrome (2011) Int. J. Biosci., 1, pp. 118-124. Cited 2 times. 43 Bertrais, S., Beyeme-Ondoua, J.-P., Czernichow, S., Galan, P., Hercberg, S., Oppert, J.-M. Sedentary behaviors, physical activity, and metabolic syndrome in middle-aged French subjects (2005) Obesity Research, 13 (5), pp. 936-944. Cited 177 times. http://www.obesityresearch.org/ doi: 10.1038/oby.2005.108 View at Publisher 44 Wagner, A., Dallongeville, J., Haas, B., Ruidavets, J.B., Amouyel, P., Ferrières, J., Simon, C., (...), Arveiler, D. Sedentary behaviour, physical activity and dietary patterns are independently associated with the metabolic syndrome (2012) Diabetes and Metabolism, 38 (5), pp. 428-435. Cited 38 times. doi: 10.1016/j.diabet.2012.04.005 View at Publisher 45 Kahn, S.E., Prigeon, R.L., McCulloch, D.K., Boyko, E.J., Bergman, R.N., Schwartz, M.W., Neifing, J.L., (...), Porte Jr., D. Quantification of the relationship between insulin sensitivity and β- cell function in human subjects: Evidence for a hyperbolic function (1993) Diabetes, 42 (11), pp. 1663-1672. Cited 1166 times. View at Publisher 46 Nagaev, I., Bokarewa, M., Tarkowski, A., Smith, U. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes (Open Access) (2006) PLoS ONE, 1 (1), art. no. e31. Cited 118 times. http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0000031&representation=PDF doi: 10.1371/journal.pone.0000031 View at Publisher 47 Takhshid, M.A., Zare, Z. Resistin - 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus (Open Access) (2015) Journal of Diabetes and Metabolic Disorders, 14 (1), art. no. 37. Cited 18 times. http://www.jdmdonline.com/ doi: 10.1186/s40200-015-0165-y View at Publisher 48 De Luis, D.A., Gonzalez Sagrado, M., Conde, R., Aller, R., Izaola, O., Primo, D. Lack of association of serum resistin levels with metabolic syndrome criteria in obese female patients (2011) Clinical Biochemistry, 44 (16), pp. 1280-1283. Cited 14 times. doi: 10.1016/j.clinbiochem.2011.09.002 View at Publisher 49 Qasim, A.N., Metkus, T.S., Tadesse, M., Lehrke, M., Restine, S., Wolfe, M.L., Hannenhalli, S., (...), Reilly, M.P. Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians (2009) Clinical Endocrinology, 70 (5), pp. 698-705. Cited 29 times. doi: 10.1111/j.1365-2265.2008.03375.x View at Publisher 50 Menzaghi, C., Coco, A., Salvemini, L., Thompson, R., De Cosmo, S., Doria, A., Trischitta, V. Brief Report: Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic caucasians (Open Access) (2006) Journal of Clinical Endocrinology and Metabolism, 91 (7), pp. 2792-2795. Cited 109 times. http://jcem.endojournals.org/cgi/reprint/91/7/2792 doi: 10.1210/jc.2005-2715 View at Publisher 51 Patel, L., Buckels, A.C., Kinghorn, I.J., Murdock, P.R., Holbrook, J.D., Plumpton, C., Macphee, C.H., (...), Smith, S.A. Resistin is expressed in human macrophages and directly regulated by PPARγ activators (2003) Biochemical and Biophysical Research Communications, 300 (2), pp. 472-476. Cited 731 times. doi: 10.1016/S0006-291X(02)02841-3 View at Publisher 52 Booth, A., Magnuson, A., Foster, M. Detrimental and protective fat: Body fat distribution and its relation to metabolic disease (2014) Hormone Molecular Biology and Clinical Investigation, 17 (1), pp. 13-27. Cited 53 times. http://www.degruyter.com/view/j/hmbci?rskey=UasnvS&result=1&q=Hormone Molecular Biology and Clinical Investigation doi: 10.1515/hmbci-2014-0009 View at Publisher 53 Tan, M.-S., Chang, S.-Y., Chang, D.-M., Tsai, J.C.-R., Lee, Y.-J. Association of resistin gene 3′-untranslated region +62G→A polymorphism with type 2 diabetes and hypertension in a Chinese population (Open Access) (2003) Journal of Clinical Endocrinology and Metabolism, 88 (3), pp. 1258-1263. Cited 64 times. doi: 10.1210/jc.2002-021453 View at Publisher 54 Gouni-Berthold, I., Giannakidou, E., Faust, M., Kratzsch, J., Berthold, H.K., Krone, W. Resistin gene 3′-untranslated region +62G→A polymorphism is associated with hypertension but not diabetes mellitus type 2 in a German population (2005) Journal of Internal Medicine, 258 (6), pp. 518-526. Cited 25 times. doi: 10.1111/j.1365-2796.2005.01566.x View at Publisher 55 Suriyaprom, K., Phonrat, B., Namjuntra, P., Chanchay, S., Tungtrongchitr, R. The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais (Open Access) (2009) Journal of Clinical Biochemistry and Nutrition, 44 (1), pp. 104-110. Cited 14 times. doi: 10.3164/jcbn.08-224 View at Publisher 56 Escobar-Morreale, H.F., Villuendas, G., Botella-Carretero, J.I., Álvarez-Blasco, F., Sanchón, R., Luque-Ramírez, M., San Millán, J.L. Adiponectin and resistin in PCOS: A clinical, biochemical and molecular genetic study (Open Access) (2006) Human Reproduction, 21 (9), pp. 2257-2265. Cited 144 times. http://humrep.oxfordjournals.org/ doi: 10.1093/humrep/del146 View at Publisher 57 Chen, Y.-H., Hung, P.-F., Kao, Y.-H. IGF-I downregulates resistin gene expression and protein secretion (2005) American Journal of Physiology - Endocrinology and Metabolism, 288 (5 51-5), pp. E1019-E1027. Cited 33 times. doi: 10.1152/ajpendo.00325.2004 View at Publisher 58 Miyamoto, Y., Morisaki, H., Kokubo, Y., Yamanaka, I., Tomoike, H., Okayama, A., Yoshimasa, Y., (...), Morisaki, T. Resistin gene variations are associated with the metabolic syndrome in Japanese men (2009) Obesity Research and Clinical Practice, 3 (2), pp. 65-74. Cited 17 times. doi: 10.1016/j.orcp.2008.11.003 View at Publisher 59 Zayani, N., Omezzine, A., Boumaiza, I., Achour, O., Rebhi, L., Rejeb, J., Ben Rejeb, N., (...), Bouslama, A. Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study (Open Access) (2017) Journal of Clinical Laboratory Analysis, 31 (6), art. no. e22148. Cited 9 times. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2825 doi: 10.1002/jcla.22148 View at Publisher 60 Savage, D.B., Sewter, C.P., Klenk, E.S., Segal, D.G., Vidal-Puig, A., Considine, R.V., O'Rahilly, S. Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator - Activated Receptor-γ Action in Humans (Open Access) (2001) Diabetes, 50 (10), pp. 2199-2202. Cited 665 times. http://diabetes.diabetesjournals.org/ doi: 10.2337/diabetes.50.10.2199 View at Publisher 61 Asano, H., Izawa, H., Nagata, K., Nakatochi, M., Kobayashi, M., Hirashiki, A., Shintani, S., (...), Yokota, M. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population (2010) Diabetologia, 53 (2), pp. 234-246. Cited 60 times. doi: 10.1007/s00125-009-1517-2 View at Publisher 62 Lau, C.-H., Muniandy, S. Adiponectin and Resistin Gene Polymorphisms in Association with Their Respective Adipokine Levels (2011) Annals of Human Genetics, 75 (3), pp. 370-382. Cited 30 times. doi: 10.1111/j.1469-1809.2010.00635.x View at Publisher 63 Ukkola, O., Kunnari, A., Kesäniemi, Y.A. Genetic variants at the resistin locus are associated with the plasma resistin concentration and cardiovascular risk factors (2008) Regulatory Peptides, 149 (1-3), pp. 56-59. Cited 31 times. doi: 10.1016/j.regpep.2007.08.025 View at Publisher 64 Mattevi, V.S., Zembrzuski, V.M., Hutz, M.H. A resistin gene polymorphism is associated with body mass index in women (2004) Human Genetics, 115 (3), pp. 208-212. Cited 56 times. http://www.springerlink.com/content/100421/ doi: 10.1007/s00439-004-1128-4 View at Publisher 65 Hivert, M.-F., Manning, A.K., McAteer, J.B., Dupuis, J., Fox, C.S., Cupples, L.A., Meigs, J.B., (...), Florez, J.C. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the framingham offspring study (Open Access) (2009) Diabetes, 58 (3), pp. 750-756. Cited 67 times. http://diabetes.diabetesjournals.org/cgi/reprint/58/3/750 doi: 10.2337/db08-1339 View at Publisher 66 Boumaiza, I., Omezzine, A., Rejeb, J., Rebhi, L., Ben Rejeb, N., Nabli, N., Ben Abdelaziz, A., (...), Bouslama, A. Association between four resistin polymorphisms, obesity, and metabolic syndrome parameters in tunisian volunteers (2012) Genetic Testing and Molecular Biomarkers, 16 (12), pp. 1356-1362. Cited 18 times. doi: 10.1089/gtmb.2012.0156 View at Publisher 67 Sentinelli, F., Romeo, S., Arca, M., Filippi, E., Leonetti, F., Banchieri, M., Di Mario, U., (...), Baroni, M.G. Human resistin gene, obesity, and type 2 diabetes: Mutation analysis and population study (Open Access) (2002) Diabetes, 51 (3), pp. 860-862. Cited 106 times. http://diabetes.diabetesjournals.org/ doi: 10.2337/diabetes.51.3.860 View at Publisher 68 Chi, S., Lan, C., Zhang, S., Liu, H., Wang, X., Chen, Y., Chen, X., (...), Zhang, W. Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese (2009) Molecular and Cellular Biochemistry, 330 (1-2), pp. 31-38. Cited 12 times. doi: 10.1007/s11010-009-0097-2 View at Publisher 69 Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.-X., Kawamata, Y., (...), Fujino, M. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor (1998) Biochemical and Biophysical Research Communications, 251 (2), pp. 471-476. Cited 1077 times. http://www.sciencedirect.com/science/journal/0006291X doi: 10.1006/bbrc.1998.9489 View at Publisher 70 Su, W. (2005) Plasma Level and 3’-Untranslated Region+ 62 G/A of Polymorphism of Resistin in Taiwanese with Metabolic Syndrome and Ischemic Cerebral Vascular Disease(Thesis). Cited 2 times. Biologic Sci., Online 71 Xia, Z., Wang, Z., Cai, Q., Yang, J., Zhang, X., Yang, T. Prevalence and risk factors of type 2 diabetes in the adults in Haikou city, Hainan Island, China (2013) Iranian Journal of Public Health, 42 (3), pp. 222-230. Cited 15 times. http://ijph.tums.ac.ir/index.php/IJPH/article/view/2884/2094 72 Bhatti, G.K., Puar, S.K., Saini, N.K., Bhadada, S.K., Vijayvergiya, R., Mastana, S.S. Evaluation of risk factors associated with type 2 diabetes and related complications in Asian Indians: The North Indian diabetes and cardiovascular disease (nidcvd) study-i (2014) J. Diabetes. Metab.. Cited 5 times. 73 Naja, F., Hwalla, N., Itani, L., Salem, M., Azar, S.T., Zeidan, M.N., Nasreddine, L. Dietary patterns and odds of Type 2 diabetes in Beirut, Lebanon: A case-control study (Open Access) (2012) Nutrition and Metabolism, 9 (1), art. no. 111. Cited 34 times. http://www.nutritionandmetabolism.com/home/ doi: 10.1186/1743-7075-9-111 View at Publisher 74 Li, L., Yang, G., Li, Q., Tang, Y., Yang, M., Yang, H., Li, K. Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects (2006) Experimental and Clinical Endocrinology and Diabetes, 114 (10), pp. 544-548. Cited 198 times. doi: 10.1055/s-2006-948309 View at Publisher 75 Khalil, O., Alnahal, A., Ghonium, M., Fawzy, S., Ibrahem, M. Does resistin gene polymorphisms +299 (G>a) participate in insulin resistance in egyption non-obese type 2 diabetes? (2014) Int. J. Gen. Med., 2, p. 117

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