Anti-epileptic potential, metabolic profiling and in silico studies of the aqueous fraction from O cimum menthiifolium benth, family Lamiaceae
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | Zahran, Eman Maher | |
| dc.contributor.author | Usama, Ramadan | |
| dc.contributor.author | Abdel mohsen, Ahmed | |
| dc.contributor.author | Kolkeila, M Alaraby | |
| dc.contributor.author | Salem, Ezzat | |
| dc.contributor.author | Khalil, Yehia | |
| dc.contributor.author | Desoukey, Ahmed | |
| dc.contributor.author | Fouad, Mohamed Salah | |
| dc.contributor.author | Abdel mohsen, Usama Ramadan | |
| dc.contributor.author | Kolkeila, Ahmed | |
| dc.contributor.author | Salem, Mohammad Alaraby | |
| dc.contributor.author | Khalil, Hany Ezzat | |
| dc.contributor.author | Desoukey, Samar Yehia | |
| dc.contributor.author | Fouad, Ahmed | |
| dc.contributor.author | Kamel, Mohamed Salah | |
| dc.date.accessioned | 2020-08-26T19:41:59Z | |
| dc.date.available | 2020-08-26T19:41:59Z | |
| dc.date.issued | 2020-08-18 | |
| dc.description | SJR 2024 0.398 Q2 H-Index 76 | |
| dc.description.abstract | The current study aimed to investigate the anti-epileptic potential of the ethanol extract and its different fractions from the Lamiaceous plant, Ocimum menthiifolium. The results revealed that the aqueous fraction with the latest onset of myoclonic convulsions (1095 ± 45**** s) was the most biologically active one. This was followed by LC-HR-MS-coupled metabolic profiling which led to dereplication of 8 compounds from that fraction. A molecular docking study was performed on the dereplicated compounds to discover the main responsible ones for the activity. The results highlighted Apigenin-7,4'-di-O-glucoside as the top scoring ligand with a possible mechanism of action involving the modulation of the voltage-gated sodium channel. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=24819&tip=sid&clean=0 | |
| dc.identifier.citation | Zahran, E. M., Abdelmohsen, U. R., Kolkeila, A., Salem, M. A., Khalil, H. E., Desoukey, S. Y., Fouad, M. A., & Kamel, M. S. (2020). Anti-epileptic potential, metabolic profiling and in silico studies of the aqueous fraction from Ocimum menthiifolium benth, family Lamiaceae. Natural Product Research, 35(24), 5972–5976. https://doi.org/10.1080/14786419.2020.1809396 | |
| dc.identifier.doi | https://doi.org/10.1080/14786419.2020.1809396 | |
| dc.identifier.other | https://doi.org/10.1080/14786419.2020.1809396 | |
| dc.identifier.uri | https://t.ly/kTCr | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Taylor and Francis Ltd | en_US |
| dc.relation.ispartofseries | NATURAL PRODUCT RESEARCH;Volume 35, 2021 , Issue 24 | |
| dc.subject | Ocimum menthiifolium | en_US |
| dc.subject | LC-HR-MS | en_US |
| dc.subject | anti-epileptic | en_US |
| dc.subject | aqueous fraction | en_US |
| dc.subject | molecular docking | en_US |
| dc.title | Anti-epileptic potential, metabolic profiling and in silico studies of the aqueous fraction from O cimum menthiifolium benth, family Lamiaceae | en_US |
| dc.type | Article | en_US |