Validation of Anti‑pyretic‑Derived Natural Products and Their Potentials for Drug Discovery
dc.Affiliation | October university for modern sciences and Arts MSA | |
dc.contributor.author | Zayed, Ahmed | |
dc.contributor.author | Salem, Mohamed A | |
dc.contributor.author | Negm, Walaa A | |
dc.contributor.author | Ezzat, Shahira M | |
dc.date.accessioned | 2023-05-26T08:01:46Z | |
dc.date.available | 2023-05-26T08:01:46Z | |
dc.date.issued | 2023-05 | |
dc.description.abstract | Fever is a complicated process that occurs in response to infection and infammatory diseases, stimulating the immune system that may cause severe biological changes in the human body. Hence, anti-pyretic agents are prescribed to reduce elevated body temperature in order to maintain thermal homeostasis and protect the brain from damage. Additionally, there is always a growing need for safe and efective anti-pyretic drugs derived from natural products, especially that anti-pyretic pathways have been investigated well in previous literature. Many animal models are established for assessing anti-pyretic candidates resulting in two types of anti-pyretics. They are the endogenous anti-pyretics that act as a defense mechanism for temperature regulation and the exogenous anti-pyretics. The current article discusses the main anti-pyretic pathways, models for assessing anti-pyretics, metabolomics applications in anti-pyretic assays, and screening of anti-pyretic and analgesic natural products. Screening of plant-derived natural products and active principles with anti-pyretic, anti-infammatory, and analgesic activities, in addition to their mechanism of action and validation methods, is described in the current article. Hence, this review could contribute to the introduction of a site-specifc and safe naturally derived anti-pyretic medications with potential therapeutic qualities compared to currently available synthetic anti-pyretics. | en_US |
dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=5400152628&tip=sid&clean=0 | |
dc.identifier.doi | https://doi.org/10.1007/s43450-023-00403-9 | |
dc.identifier.other | https://doi.org/10.1007/s43450-023-00403-9 | |
dc.identifier.uri | http://repository.msa.edu.eg/xmlui/handle/123456789/5584 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature Switzerland AG | en_US |
dc.relation.ispartofseries | Revista Brasileira de Farmacognosia; | |
dc.subject | Animal models · | en_US |
dc.subject | Anti-pyretic pathways · | en_US |
dc.subject | Fever · | en_US |
dc.subject | Metabolomics · | en_US |
dc.subject | Plant sources · | en_US |
dc.subject | Active principles · | en_US |
dc.subject | Validation | en_US |
dc.title | Validation of Anti‑pyretic‑Derived Natural Products and Their Potentials for Drug Discovery | en_US |
dc.type | Article | en_US |