Validation of Anti‑pyretic‑Derived Natural Products and Their Potentials for Drug Discovery

dc.AffiliationOctober university for modern sciences and Arts MSA
dc.contributor.authorZayed, Ahmed 
dc.contributor.authorSalem, Mohamed A
dc.contributor.authorNegm, Walaa A
dc.contributor.authorEzzat, Shahira M
dc.date.accessioned2023-05-26T08:01:46Z
dc.date.available2023-05-26T08:01:46Z
dc.date.issued2023-05
dc.description.abstractFever is a complicated process that occurs in response to infection and infammatory diseases, stimulating the immune system that may cause severe biological changes in the human body. Hence, anti-pyretic agents are prescribed to reduce elevated body temperature in order to maintain thermal homeostasis and protect the brain from damage. Additionally, there is always a growing need for safe and efective anti-pyretic drugs derived from natural products, especially that anti-pyretic pathways have been investigated well in previous literature. Many animal models are established for assessing anti-pyretic candidates resulting in two types of anti-pyretics. They are the endogenous anti-pyretics that act as a defense mechanism for temperature regulation and the exogenous anti-pyretics. The current article discusses the main anti-pyretic pathways, models for assessing anti-pyretics, metabolomics applications in anti-pyretic assays, and screening of anti-pyretic and analgesic natural products. Screening of plant-derived natural products and active principles with anti-pyretic, anti-infammatory, and analgesic activities, in addition to their mechanism of action and validation methods, is described in the current article. Hence, this review could contribute to the introduction of a site-specifc and safe naturally derived anti-pyretic medications with potential therapeutic qualities compared to currently available synthetic anti-pyretics.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=5400152628&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s43450-023-00403-9
dc.identifier.otherhttps://doi.org/10.1007/s43450-023-00403-9
dc.identifier.urihttp://repository.msa.edu.eg/xmlui/handle/123456789/5584
dc.language.isoen_USen_US
dc.publisherSpringer Nature Switzerland AGen_US
dc.relation.ispartofseriesRevista Brasileira de Farmacognosia;
dc.subjectAnimal models ·en_US
dc.subjectAnti-pyretic pathways ·en_US
dc.subjectFever ·en_US
dc.subjectMetabolomics ·en_US
dc.subjectPlant sources ·en_US
dc.subjectActive principles ·en_US
dc.subjectValidationen_US
dc.titleValidation of Anti‑pyretic‑Derived Natural Products and Their Potentials for Drug Discoveryen_US
dc.typeArticleen_US

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