Interaction between 12p chromosomal abnormalities and Lnc-HOTAIR mediated pathway in acute myeloid leukemia

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Khazragy N.
dc.contributor.authorGhozy S.
dc.contributor.authorMatbouly S.
dc.contributor.authorZaki W.
dc.contributor.authorSafwat G.
dc.contributor.authorHussien G.
dc.contributor.authorKhalifa O.
dc.contributor.otherClinical Pathology and Haematology Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherAin Shams University Biomedical Research Department
dc.contributor.otherCairo
dc.contributor.otherEgypt; Neurosurgery Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMansoura University
dc.contributor.otherMansoura
dc.contributor.otherEgypt; Department of Paediatric
dc.contributor.otherFaculty of Medicine
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Biochemistry
dc.contributor.otherFaculty of Medicine
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Molecular Biology
dc.contributor.otherFaculty of Biotechnology
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:34Z
dc.date.available2020-01-09T20:40:34Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractObjectives: To investigate the correlation of homeobox (HOX) transcript antisense RNA expression with clinicopathological features and the clinical prognosis of the patients with chromosome 12p abnormalities associated acute myeloid leukemia (AML). We also investigate the association of 12p chromosomal on the expression of HOTAIR, miRNA-193a, and c-kit gene as targeting genes for HOTAIR in AML. Methods: AML patients with 12p chromosomal abnormalities were recruited and compared to AML with other chromosomal abnormalities rather than 12p. The long noncoding RNA (lncRNA) �HOTAIR,� miR-193a, and c-Kit genes expression were measured in bone marrow samples using Syber green based real-time polymerase chain reaction. Results: We found a significant difference for the expression levels of HOTAIR, c-kit, and miR-193a between 12p abnormalities associated AML and those without. The survival analysis revealed that patient's with low expression levels of HOTAIR and c-kit had significantly better survival and leukemia free survival. In contrast, miR-193a was associated with better overall survival but not leukemia free survival. Conclusion: 12p abnormalities associated AML were associated with worse prognosis. Our results proved that HOTAIR, miR-193a, and c-kit genes are independent prognostic predictors in 12p chromosomal associated AML; therefore it may represent a novel therapeutic application in AML in the future. � 2019 Wiley Periodicals, Inc.en_US
dc.identifier.doihttps://doi.org/10.1002/jcb.28796
dc.identifier.doiPubMedID31038787
dc.identifier.issn7302312
dc.identifier.otherhttps://doi.org/10.1002/jcb.28796
dc.identifier.otherPubMedID31038787
dc.identifier.urihttps://t.ly/DXGyl
dc.language.isoEnglishen_US
dc.publisherWiley-Liss Inc.en_US
dc.relation.ispartofseriesJournal of Cellular Biochemistry
dc.relation.ispartofseries120
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subject12p aberrationsen_US
dc.subject12p deletionen_US
dc.subjectacute myeloid leukemiaen_US
dc.subjectc-KITen_US
dc.subjecthomeobox transcript antisense RNAen_US
dc.subjectmiR-193aen_US
dc.subjectanthracyclineen_US
dc.subjectasparaginaseen_US
dc.subjectcomplementary DNAen_US
dc.subjectcomplementary RNAen_US
dc.subjectcorticosteroiden_US
dc.subjecthomeobox transcript antisense RNAen_US
dc.subjectlong untranslated RNAen_US
dc.subjectmicroRNAen_US
dc.subjectmicroRNA 193aen_US
dc.subjectstem cell factor receptoren_US
dc.subjectunclassified drugen_US
dc.subjectvincristineen_US
dc.subjectacute myeloid leukemiaen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectbone marrowen_US
dc.subjectcancer prognosisen_US
dc.subjectcancer specific survivalen_US
dc.subjectchromosome 12pen_US
dc.subjectchromosome aberrationen_US
dc.subjectchromosome deletionen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjectgene targetingen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthuman tissueen_US
dc.subjectinduction chemotherapyen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectminimal residual diseaseen_US
dc.subjectoverall survivalen_US
dc.subjectpriority journalen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectsurvival analysisen_US
dc.titleInteraction between 12p chromosomal abnormalities and Lnc-HOTAIR mediated pathway in acute myeloid leukemiaen_US
dc.typeArticleen_US
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