Substituted 4,5,6,7-tetrahydroindoles and their fused derivatives. Synthesis and cytotoxic activity towards tumor and normal human cell lines
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Date
2013
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
SPRINGER
Series Info
CHEMISTRY OF HETEROCYCLIC COMPOUNDS;Volume: 49 Issue: 8 Pages: 1212-1223
Doi
Scientific Journal Rankings
Abstract
This work has been carried out to explore the reaction of 2-cyanoacetohydrazide with cyclohexanone to form 4,5,6,7-tetrahydroindole derivatives. 2-Hydroxy-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile was used as the starting material for a series of novel heterocyclic products containing fused oxazine, pyran, pyrazole, pyridazine, and thiophene rings. The antitumor activity evaluation of the newly synthesized compounds against three human tumor cells lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460), and CNS cancer (SF-268), and with normal fibroblast cells (WI 38) showed that some of these compounds exhibit much higher inhibitory effects towards the three tumor cell lines than the reference drug doxorubicin while being minimally active towards normal cells.
Description
Accession Number: WOS:000326375500016
Keywords
University of DRUG DISCOVERY, Indoles, Pyrans, Antitumor activity