Hepatoprotective constituents of Torilis radiata Moench (Apiaceae)

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEzzat, Shahira M
dc.contributor.authorM Abdallah, Hossam
dc.contributor.authorA Fawzy, Ghada
dc.contributor.authorA El-Maraghy, Shohda
dc.date.accessioned2019-11-04T06:41:43Z
dc.date.available2019-11-04T06:41:43Z
dc.date.issued2012
dc.descriptionMSA Google Scholar
dc.description.abstractAn investigation of the aqueous ethanolic extract (AE) of the aerial parts of Torilis radiata Moench yielded two triterpenes (lupeol acetate 1 and α-amyrin 2), a sterol (spinasterol 3) from its n-hexane fraction (HF), a flavone (acacetin 4), a coumarin (scopoletin 5), a phenolic acid (ferulic acid 6) from the chloroform fraction (CF) and a flavone glycoside (luteolin-7- O-glucoside 7) from the n-butanol fraction (BF). The hepatoprotection of the AE and its fractions was assessed in terms of the reduction in histological damage, accompanied by restoration of the liver enzymes (alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH)), a reduction in the inflammatory markers (tumour necrosis-α (TNF-α), nitric oxide (NO), N-acetyl-β-D-glucosaminidase (NAG) and myloperoxidase (MPO) in serum), and a restoration of the oxidant balance through decreasing the serum and hepatic malondialdehyde (MDA) levels, along with increasing the activity of hepatic catalase (CAT), glutathione peroxidase (GSHPx) and the non-enzymatic antioxidant glutathione (GSH).en_US
dc.description.sponsorshipTaylor & Francis Groupen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24819&tip=sid&clean=0
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dc.identifier.doihttps://doi.org/
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://cutt.ly/KtwkrJd
dc.language.isoenen_US
dc.publisherTaylor & Francis Groupen_US
dc.relation.ispartofseriesNatural product research;26:3 , 282-285
dc.subjectantioxidanten_US
dc.subjectanti-inflammatoryen_US
dc.subjecthepatoprotectiveen_US
dc.subjectTorilis radiataen_US
dc.titleHepatoprotective constituents of Torilis radiata Moench (Apiaceae)en_US
dc.typeArticleen_US

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