Production of L-Asparaginase (L-ASN) from endophytic Lasiodiplodia theobromae hosted Teucrium polium in Egypt
Date
2018
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Microbial Biosystems Journal
Series Info
Microbial Biosystems;Volume: 3 Issue: 2 Pages: 46-55
Doi
Scientific Journal Rankings
Abstract
Endophytic fungi produce important bioactive primary and secondary metabolites.
Researchers used L-Asparaginase for the treatment of Acute Lymphoblastic leukemia (ALL).
Endophytic taxon, Lasiodiplodia theobromae (Pat.) Griff. and Maubl. has been isolated from
Teucrium polium plant tissues collected from Saint Katherine Protectorate and was screened for
its ability to produce L-Asparaginase qualitatively and quantitatively. The crude enzyme has
been partially purified using gel-filtration Sephadex G-100 with an activity of 21.00 lMmL-1
min-1
. The results revealed that L. theobromae (SCUF-TP2016) represents a rich source of
bioactive metabolites that can be manipulated to produce L-Asparaginase which is a desirable
novel analog for chemotherapy.
Description
MSA Google Scholar
Keywords
University of Anti-leukemic, enzymes, Saint Katherine Protectorate, gel filtration
Citation
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