Molecular modeling and preclinical evaluation of radioiodinated tenoxicam for inflammatory disease diagnosis

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSakr T.M.
dc.contributor.authorIbrahim I.T.
dc.contributor.authorAbd-Alla W.H.
dc.contributor.otherRadioactive Isotopes and Generator Department
dc.contributor.otherHot Labs Center
dc.contributor.otherAtomic Energy Authority
dc.contributor.otherP.O. 13759
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University of Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Labelled Compound Department
dc.contributor.otherHot Labs Center
dc.contributor.otherAtomic Energy Authority
dc.contributor.otherP.O. 13759
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutical Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMisr University for Science & Technology
dc.contributor.otherP.O. 77
dc.contributor.other6th of October
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:56Z
dc.date.available2020-01-09T20:40:56Z
dc.date.issued2018
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractAbstract: The aim of the presented study is to investigate a new promising radiopharmaceutical tracer able to visualize and differentiate inflammation versus infection in early stages. Radioiodinated tenoxicam (125I-tenoxicam) was prepared and its radiochemical yield and in vitro stability were assayed. The biodistribution studies were conducted on two different mice models: sterile inflammation and bacterial infection mice models. 125I-tenoxicam showed high T/NT accumulation in the inflammatory tissues revealing high selectivity to the inflammatory tissues in contrast to infection bearing mice. The docking study using CDOCKER protocol for tenoxicam and radioiodinated tenoxicam with COX enzymes was performed to confirm that radioiodinated tenoxicam still retaining COX enzymes selectivity. � 2018, Akad�miai Kiad�, Budapest, Hungary.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24060&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s10967-018-5770-z
dc.identifier.doiPubMed ID :
dc.identifier.issn2365731
dc.identifier.otherhttps://doi.org/10.1007/s10967-018-5770-z
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/MXMOd
dc.language.isoEnglishen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofseriesJournal of Radioanalytical and Nuclear Chemistry
dc.relation.ispartofseries316
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectCyclooxygensase enzymeen_US
dc.subjectImagingen_US
dc.subjectInflammationen_US
dc.subjectMolecular dockingen_US
dc.subjectRadioiodinationen_US
dc.subjectTenoxicamen_US
dc.subjectcelecoxiben_US
dc.subjectibuprofenen_US
dc.subjectiodine 125en_US
dc.subjecttenoxicamen_US
dc.subjecttosylchloramide sodiumen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectbacterial infectionen_US
dc.subjectbinding affinityen_US
dc.subjectbinding siteen_US
dc.subjectconcentration (parameters)en_US
dc.subjectcontrolled studyen_US
dc.subjectdrug distributionen_US
dc.subjectdrug stabilityen_US
dc.subjectdrug structureen_US
dc.subjecthydrogen bonden_US
dc.subjectin vitro studyen_US
dc.subjectinflammatory diseaseen_US
dc.subjectmolecular dockingen_US
dc.subjectmolecular interactionen_US
dc.subjectmolecular modelen_US
dc.subjectmouseen_US
dc.subjectmouse modelen_US
dc.subjectnonhumanen_US
dc.subjectpH measurementen_US
dc.subjectpreclinical studyen_US
dc.subjectradioactivityen_US
dc.subjectradiochemistryen_US
dc.subjectradioiodinationen_US
dc.subjectreaction timeen_US
dc.titleMolecular modeling and preclinical evaluation of radioiodinated tenoxicam for inflammatory disease diagnosisen_US
dc.typeArticleen_US
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