Diosmin/essential oil combination for dermal photo-protection using a lipoid colloidal carrier

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorKamel R.
dc.contributor.authorAbbas H.
dc.contributor.authorFayez A.
dc.contributor.otherPharmaceutical Technology Department
dc.contributor.otherNational Research Center
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmaceutics Department
dc.contributor.otherDamanhour University
dc.contributor.otherEgypt; Pharmacology Department
dc.contributor.otherOctober University for Modern Science and Arts University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:20Z
dc.date.available2020-01-09T20:41:20Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractSolar irradiation induces skin inflammatory processes causing deleterious effects like premature ageing. In this study, the designed lipoid colloidal carrier (LCC) was loaded with Diosmin in combination with different essential oils, to be used as a topical photo-protective preparation. To investigate the ability of the essential oils to potentiate Diosmin effects, the Diosmin/essential oil-loaded LCCs (LCC2, LCC3 and LCC4) were compared to the Diosmin-loaded LCC (LCC1). The incorporated essential oils were those of Rosmarinus officinalis, Zingiber officinale or Vitis vinifera in LCC2, LCC3 and LCC4, respectively. All the LCCs had particle size (PS) values ranging from 121.1 to 144.3�nm with uniform distribution and, zeta potential (Z) values around 30�mV. Also, they all had high drug encapsulation efficiencies. LCC1 had the lowest anti-oxidant and in-vitro sun-blocking effect (p�<�0.05). In-vivo photo-protective studies showed that all the formulated LCCs had a skin protective effect when compared to the positive control (p�<�0.05); however LCC1 had the lowest anti-erythemal and anti-wrinkling effect. Histological studies proved the efficacy of the designed LCCs as skin anti-photoageing, with LCC1 showing the lowest anti-inflammatory and anti-wrinkling effect, while LCC2 had the highest anti-wrinkling effect. These results indicated that the suggested Diosmin/essential oil combinations improved the anti-oxidant, sun-blocking and anti-photoageing effects of Diosmin. After one year of storage, the LCCs showed satisfactory physical stability. This study presents the designed LCCs as safe and effective nano-structured dermal care products containing �all-natural� components. � 2017 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=17622&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.jphotobiol.2017.03.019
dc.identifier.doiPubMed ID 2890258
dc.identifier.issn10111344
dc.identifier.otherhttps://doi.org/10.1016/j.jphotobiol.2017.03.019
dc.identifier.otherPubMed ID 2890258
dc.identifier.urihttps://t.ly/wE6pP
dc.language.isoEnglishen_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesJournal of Photochemistry and Photobiology B: Biology
dc.relation.ispartofseries170
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectAgeingen_US
dc.subjectDiosminen_US
dc.subjectEssential oilen_US
dc.subjectNano-carriersen_US
dc.subjectSkinen_US
dc.subjectSolaren_US
dc.subjectWrinklesen_US
dc.subjectantiinflammatory agenten_US
dc.subjectdiosminen_US
dc.subjectdrug carrieren_US
dc.subjectessential oilen_US
dc.subjectlipoid colloidal carrieren_US
dc.subjectoxidizing agenten_US
dc.subjectskin protective agenten_US
dc.subjectsunscreenen_US
dc.subjectunclassified drugen_US
dc.subjectantioxidanten_US
dc.subjectdiosminen_US
dc.subjectdrug carrieren_US
dc.subjectessential oilen_US
dc.subjectnanomaterialen_US
dc.subjectsunscreenen_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectgingeren_US
dc.subjectgrapeen_US
dc.subjecthistologyen_US
dc.subjectmaleen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectparticle sizeen_US
dc.subjectphotoagingen_US
dc.subjectpriority journalen_US
dc.subjectrosemaryen_US
dc.subjectskin protectionen_US
dc.subjectwrinkleen_US
dc.subjectzeta potentialen_US
dc.subjectanimalen_US
dc.subjectchemistryen_US
dc.subjectdrug effectsen_US
dc.subjectmetabolismen_US
dc.subjectpathologyen_US
dc.subjectradiation responseen_US
dc.subjectRosmarinusen_US
dc.subjectskinen_US
dc.subjecttransmission electron microscopyen_US
dc.subjectultraviolet radiationen_US
dc.subjectVitisen_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectDiosminen_US
dc.subjectDrug Carriersen_US
dc.subjectGingeren_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectMicroscopy, Electron, Transmissionen_US
dc.subjectNanostructuresen_US
dc.subjectOils, Volatileen_US
dc.subjectParticle Sizeen_US
dc.subjectRosmarinusen_US
dc.subjectSkinen_US
dc.subjectSunscreening Agentsen_US
dc.subjectUltraviolet Raysen_US
dc.subjectVitisen_US
dc.titleDiosmin/essential oil combination for dermal photo-protection using a lipoid colloidal carrieren_US
dc.typeArticleen_US
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